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Significance of peptides citrullinated by peptidylarginine deiminase from Porphyromonas gingivalis in periodontitis.

2012/07/B/NZ6/03524

Keywords:

citrullination Porphyromonas gingivalis,inflammatory response resorption gingiva

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_2: Biochemistry
  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Gawron 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 687 180 PLN

Project start date (Y-m-d): 2013-07-18

Project end date (Y-m-d): 2018-01-17

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro - findings from the study of hereditary and idiopathic gingival fibromatosis.
    Authors:
    Gawron K., Łazarz-Bartyzel K., Kowalska A., Bereta G., Nowakowska Z., Plakwicz P., Potempa J., Fertala A., Chomyszyn-Gajewska M.
    Academic press:
    Connective Tissue Research (rok: 2019, tom: 60 (1), strony: 29-39), Wydawca: Taylor & Francis Inc.
    Status:
    Published
    DOI:
    10.1080/03008207.2018.1517758 - link to the publication
  2. TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis.
    Authors:
    Gawron K., Ochała-Kłos A., Nowakowska Z., Bereta G., Łazarz-Bartyzel K., Grabiec A.M., Plakwicz P., Górska R., Fertala A., Chomyszyn-Gajewska M., Potempa J.
    Academic press:
    Oral Diseases (rok: 2018, tom: 24 (8), strony: 1581-90), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/odi.12938 - link to the publication
  3. Association of distinct fine specificities of anti-citrullinated peptide antibodies with elevated immune responses to Prevotella intermedia in a subgroup of patients with rheumatoid arthritis and periodontitis.
    Authors:
    Schwenzer A., Quirke A.M., Marzeda A.M., Wong A., Montgomery A.B., Sayles H.R., Eick S., Gawron K., Chomyszyn-Gajewska M., Łazarz-Bartyzel K., Davis S., Potempa J., Kessler B.M., Fischer R., Venables P.J., Payne J.B., Mikuls T.R., Midwood K.S.
    Academic press:
    Arthritis & Rheumatology (rok: 2017, tom: 69 (12), strony: 2303-313), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/art.40227 - link to the publication
  4. In vitro Testing the Potential of a Novel Chimeric IgG Variant for Inhibiting Collagen fibrils Formation in Recurrent Hereditary Gingival Fibromatosis: Chimeric Antibody in a Gingival Model.
    Authors:
    Gawron K., Łazarz–Bartyzel K., Łazarz M., Stęplewska K., Pyrc K., Potempa J., Chomyszyn–Gajewska M.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2014, tom: 65 (4), strony: 585-91), Wydawca: Polskie Towarzystwo Fizjologiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Peptidylarginine deiminase from Porphyromonas gingivalis (PPAD) contributes to infection of gingival fibroblasts and induction of PGE2-signaling pathway.
    Authors:
    Gawron K., Bereta G., Nowakowska Z., Łazarz–Bartyzel K., Łazarz M., Szmigielski B., Mizgalska D., Buda A., Koziel J., Oruba Z., Chomyszyn–Gajewska M., Potempa J.
    Academic press:
    Molecular Oral Microbiology (rok: 2014, tom: 29 (6), strony: 321-32), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/omi.12081. - link to the publication
  6. Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis.
    Authors:
    Gawron K., Bereta G., Nowakowska Z., Łazarz-Bartyzel K., Potempa J., Chomyszyn-Gajewska M., Górska R., Plakwicz P.
    Academic press:
    Oral Diseases (rok: 2017, tom: 23 (7), strony: 983-89), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/odi.12684 - link to the publication
  1. Substitutions in the proximity of the active site of peptidylarginine deiminase from P. gingivalis - is there a correlation with enzyme activity?
    Authors:
    Bereta G, Gawron K, Łazarz-Bartyzel K, Łazarz M, Stożek K, Naskalska A, Burmistrz M, Pyrc K, Chomyszyn-Gajewska M, Potempa J.
    Conference:
    Annual Meeting at Experimental Biology 2016 (rok: 2016, ), Wydawca: Federation of American Societies for Experimental Biology
    Data:
    konferencja 38023
    Status:
    Published
  2. Novel polymorphism of peptidylarginine deiminase from P. gingivalis augments bacterial pathogenicity and severity of periodontitis.
    Authors:
    Gawron K, Bereta G, Nowakowska Z, Łazarz-Bartyzel K, Montgomery AB, Marczuk M, Kowalska A, Stożek K, Naskalska A, Burmistrz M, Pyrc K, Venables PJ, Chomyszyn-Gajewska M, Potempa J.
    Conference:
    37th European Workshop for Rheumatology Research 2017 (EWRR 2017) (rok: 2017, ), Wydawca: BMJ Publishing Group
    Data:
    konferencja 37656
    Status:
    Published
  1. Porphyromonas gingivalis peptidyl arginine deiminase: a unique bacterial PAD with implications for periodontal disease and rheumatoid arthritis.
    Authors:
    Gawron K, Montgomery A, Łazarz-Bartyzel K, Bereta G, Chomyszyn-Gajewska M, Venables P, Potempa J.
    Book:
    Protein Deimination in Human Health and Disease (rok: 2017, tom: II, strony: 99-135), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    link to the publication

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