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The role of the brain serotonergic system in the expression and activity of liver cytochrome P450.

2012/07/N/NZ7/04285

Keywords:

brain serotonergic system hypothalamic hormones pituitary hormones cytochrome P450 enzymatic activity expression regulation

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii, Polska Akademia Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Rysz 

Number of co-investigators in the project: 3

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 148 785 PLN

Project start date (Y-m-d): 2013-07-01

Project end date (Y-m-d): 2016-12-31

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450.
    Authors:
    Rysz M, Bromek E, Daniel WA
    Academic press:
    Biochemical Pharmacology (rok: 2016, tom: 99, strony: 113-122), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2015.11.014 - link to the publication
  1. Five-day activation of the brain serotonergic system decreases the expression of liver cytochrome P450 isoforms CYP1A, 2C11 and 3A
    Authors:
    Marta Rysz, Ewa Bromek, Władysława Anna Daniel
    Conference:
    19th International Conference on Cytochrome P450 (rok: 2015, ), Wydawca: ICCP450, Tokyo, Japan
    Data:
    konferencja 12-15.06.2015
    Status:
    Published
  2. Repeated stimulation of brain serotonergic system affects liver cytochrome P450
    Authors:
    Rysz M, Bromek E, Daniel WA
    Conference:
    XXVII European College of Neuropsychopharmacology (ECNP) Congress, Berlin (rok: 2014, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 18-21.10.2014 r.
    Status:
    Published
    DOI:
    link to the publication
  3. Brain serotonin regulates the expression of cytochrome liver P450 via neuroendocrine pathways involving the paraventricular and arcuate nuclei of the hypothalamus
    Authors:
    Rysz M, Bromek E, Haduch A, Daniel WA
    Conference:
    2nd Central European Biomedical Congress (rok: 2016, ), Wydawca: CEBC, Kraków, Polska
    Data:
    konferencja 15-18 czerwiec
    Status:
    Published
    DOI:
    link to the publication
  4. Activation of the brain serotonergic system decreases the expression and activity of liver cytochrome P450 isoforms CYP1A, 2C11 and 3A
    Authors:
    Rysz M, Ewa B, Daniel WA
    Conference:
    XXVIII European College of Neuropsychopharmacology (ECNP) Congress, Amsterdam (rok: 2015, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 17-20.09.2015
    Status:
    Published
    DOI:
    link to the publication

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