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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Structural studies and chemical imaging of vitamins A, E and their metabolites in healthy and pathologically altered animal tissues

2012/07/D/ST4/02214

Keywords:

vitamin A vitamin E Raman spectroscopy IR spectroscopy chemometrics tissues DFT

Descriptors:

  • ST4_3: Molecular architecture and structure
  • NZ4_12: Other related subjects
  • NZ3_14: Other related subjects

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Marzec 

Number of co-investigators in the project: 4

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 362 380 PLN

Project start date (Y-m-d): 2014-01-13

Project end date (Y-m-d): 2017-05-12

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laser do spektrometru (70 000 PLN)
  2. Dwa komputery (notebook oraz komputer stacjonarny) wyposażone w niezbędne oprogramowanie: 8 000 PLN (2 szt.) (507 PLN)
  3. Części i elementy optyki do używanych obecnie spektrometrów (6 400 PLN)
  4. Jeden komputer notebook wyposażony w niezbędne oprogramowanie: 4 000 PLN (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (9)
  1. High–resolution Raman imaging reveals spatial location of heme oxidation sites in single red blood cells of dried smears
    Authors:
    K.M. Marzec, A. Rygula, B.R. Wood, S. Chlopicki, M. Baranska
    Academic press:
    Journal of Raman Spectroscopy (rok: 2015, tom: 46, strony: 76–83), Wydawca: © John Wiley & Sons, Ltd.
    Status:
    Published
    DOI:
    10.1002/jrs.4600 - link to the publication
  2. Raman spectroscopy as a sensitive probe of soft tissue composition – Imaging of cross-sections of various organs vs. single spectra of tissue homogenates
    Authors:
    J. Dybas, K.M. Marzec, M.Z. Pacia, K. Kochan, K. Czamara, K. Chrabaszcz, E. Staniszewska-Slezak, K. Malek, M. Baranska, A. Kaczor
    Academic press:
    TrAC Trends in Analytical Chemistry (rok: 2016, tom: 85, strony: 117-127), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.trac.2016.08.014 - link to the publication
  3. Effects of low carbohydrate high protein (LCHP) diet on atherosclerotic plaque phenotype in ApoE/LDLR-/- mice: FT-IR and raman imaging
    Authors:
    T.P Wrobel, K.M. Marzec, S. Chlopicki, E. Maslak, A. Jasztal, M. Franczyk-Zarów, I. Czyzyńska-Cichoń, T. Moszkowski, R.B. Kostogrys, M. Baranska
    Academic press:
    Scientific Reports (rok: 2015, tom: 5:14002, strony: 45300), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep14002 - link to the publication
  4. IR and Raman imaging of murine brain from control and ApoE/LDLR‒/‒ mice with advanced atherosclerosis
    Authors:
    K. Kochan, K. Chrabaszcz, B. Szczur, E. Maslak, K. M. Marzec
    Academic press:
    Analyst (rok: 2016, tom: 141, strony: 5329-5338), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6an00107f - link to the publication
  5. Raman Microimaging of Murine Lungs: Insight Into The Vitamin A Content
    Authors:
    K.M. Marzec, K. Kochan, A. Fedorowicz, A. Jasztal, K. Chruszcz-Lipska, J.Cz. Dobrowolski, S. Chlopicki, M. Baranska
    Academic press:
    Analyst (rok: 2015, tom: 140, strony: 2171-2177), Wydawca: Royal Society of Chemistry, RSC Publishing
    Status:
    Published
    DOI:
    10.1039/C4AN01881H - link to the publication
  6. Raman spectroscopic studies of vitamin A content in the liver: a biomarker of healthy liver
    Authors:
    K. Kochan, K.M. Marzec, E. Maslak, S. Chlopicki, M. Baranska
    Academic press:
    Analyst (rok: 2015, tom: 140, strony: 2074-2079), Wydawca: RSC Publishing
    Status:
    Published
    DOI:
    10.1039/C4AN01878H - link to the publication
  1. Alpha-tocopherol studied by means of Raman Optical Activity and DFT calculations
    Authors:
    G. Zajac, M. Dudek, K. M. Marzec, M. Baranska ,
    Conference:
    VI International Conference of Biophysics Students (rok: 2017, ), Wydawca: Jagiellonian University
    Data:
    konferencja 19-21 maja
    Status:
    Published
  2. Raman and IR biomarkers of the early stage of lung metastasis of breast cancer in mice
    Authors:
    K.M. Marzec, K. Chrabaszcz, K. Kochan, A. Fedorowicz, A. Jasztal, L.S. Leslie, R. Bhargava, S. Chlopicki
    Conference:
    SPEC 2016 Shedding New Light on Disease (rok: 2016, ), Wydawca: Polytechnique Montréal and University of Manitoba
    Data:
    konferencja 26-30 czerwca
    Status:
    Published
  3. Vitamin A as a marker of liver condition: Raman imaging of tissues and isolated cells in models of liver injury
    Authors:
    K. Kochan, K. M. Marzec, E. Maslak, M. Baranska, S. Chlopicki
    Conference:
    XXV International Conference on Raman Spectroscopy (ICORS 2016) (rok: 2016, ), Wydawca: Universidade Federal do Ceará
    Data:
    konferencja 14-19 sierpnia
    Status:
    Published
  4. Vitamin E studied with the use of Raman spectroscopy, Raman Optical Activity and DFT calculations
    Authors:
    G. Zając, M. Dudek, K. M. Marzec, M. Baranska
    Conference:
    XXV International Conference on Raman Spectroscopy (ICORS 2016) (rok: 2016, ), Wydawca: Universidade Federal do Ceará
    Data:
    konferencja 14-19 sierpnia
    Status:
    Published
  5. Biochemical profile of the early stage of lung metastasis of breast cancer in mice- IR and Raman studies with the focus on the vitamin A content
    Authors:
    K. Chrabaszcz, K. Kochan, A. Fedorowicz, A. Jasztal, K. Szkaradek, K. Malek, K. M. Marzec, S. Chlopicki
    Conference:
    24th Kraków Conference on Endothelium (rok: 2016, ), Wydawca: Jagiellonian Cetre for Experimental Therapeutics
    Data:
    konferencja 19-21 czerwca
    Status:
    Published
  6. Raman microimaging of vitamin A content in liver and lung tissue
    Authors:
    K.M. Marzec, K. Kochan, A. Fedorowicz, E.Maslak, A. Jasztal, S. Chlopicki, M. Baranska
    Conference:
    V Interdyscyplinarne Seminarium JCET (rok: 2014, ), Wydawca: Jagiellonian Cetre for Experimental Therapeutics
    Data:
    konferencja 6-8 czerwca
    Status:
    Published
  7. Experimental and Theoretical Studies on Vitamin A – A Biochemical Marker of Liver's Condition
    Authors:
    K. Kochan, K. M. Marzec, K. Chruszcz-Lipiska, E. Maślak, J. Cz. Dobrowolski, S. Chlopicki, M. Baranska
    Conference:
    SPEC 2014 Shedding New Light on Disease (rok: 2014, ), Wydawca: Targi w Krakowie, ISBN 940104
    Data:
    konferencja 17-22 Sierpnia
    Status:
    Published
  8. Chemical imaging of vitamin A in healthy and pathologically altered murine tissues
    Authors:
    K.M. Marzec, K. Chrabaszcz, K. Kochan, A. Fedorowicz, A. Jasztal, S. Chlopicki, M. Baranska
    Conference:
    14th Scandinavian Symphosium on Chemometrics (rok: 2015, ), Wydawca: University of Perugia, Italy
    Data:
    konferencja 14-17 czerwca
    Status:
    Published
  9. Imaging of the biomarkers of atherosclerotic alternations in murine brain – IR and Raman studies
    Authors:
    K. Chrabaszcz, K. Kochan, B. Szczur, E. Maslak, J. Dybas, K. M. Marzec
    Conference:
    XXV International Conference on Raman Spectroscopy (ICORS 2016) (rok: 2016, ), Wydawca: Universidade Federal do Ceará
    Data:
    konferencja 14-19 sierpnia
    Status:
    Published

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