Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry approach and their use in the characterization of selected enzymes
2012/07/N/ST5/00178
Keywords
Descriptors
- ST5_16: Chemia biologiczna
- NZ1_2: Biochemia
- ST5_23: Chemia organiczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Uniwersytet Gdański, Wydział Chemii
Voivodeship: pomorskie
Principal investigator (from the host institution)
dr Jadwiga Danuta Popow - Stellmaszyk
Number of co-investigators in the project: 2
Call
PRELUDIUM 4 – announced on 2012-09-15
- Amount awarded
- 149 940 PLN
- Project start date
- 2013-07-09
- Project end date
- 2016-07-08
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- mieszadło z funkcją grzania.
- wyparka obrotowa. Cost: 15 000 PLN
Information in the final report
Publication in academic press/journals (1)
-
A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.
- Authors:
- J. Popow-Stellmaszyk, M. Wysocka, A. Lesner, B. Korkmaz, K. Rolka
- Academic press:
- Analytical Biochemistry (year: 2013, volume: 442, pages: 75-82), Publisher: Elsevier Inc.
- Status:
- Published
- DOI:
- 10.1016/j.ab.2013.07.028 – link to the publication
Articles in post-conference publications (1)
-
Chemical synthesis and potential use of new intramolecular quenched substrates for human neutrophil elastase and proteinase 3 in the diagnosis of lung diseases.
- Authors:
- J. Popow-Stellmaszyk, B. Popławska-Wiśniewska, M. Wysocka, J. Chorostowska-Wynimko, K. Rolka, A. Lesner
- Conference:
- 33 Europejskie Sympozjum Peptydowe (year: 2014, pages: 348-349), Publisher: John Wiley & Sons, Ltd. Journal of Peptide Science
- Date:
- conference 31.08.-05.09.2014
- Status:
- Published