Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Low level of endogenous glutathione as a cause of fever absence during infaction and inflammation

2012/07/B/NZ4/00197

Keywords:

inflammation glutathione fever

Descriptors:

  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Mikołaja Kopernika, Wydział Biologii i Ochrony Środowiska

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sylwia Wrotek 

Number of co-investigators in the project: 4

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 246 760 PLN

Project start date (Y-m-d): 2013-07-08

Project end date (Y-m-d): 2017-12-07

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Homogenizator.
  2. zamrażarka (1 549 PLN)
  3. Zestaw do utrzymywania temeratury ciała (15 000 PLN)
  4. sterylizator kulkowy (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Glutathione deficiency attenuates endotoxic fever in rats
    Authors:
    Wrotek S, Jedrzejewski T, Nowakowska A & Kozak W.
    Academic press:
    International Journal of Hyperthermia, (rok: 2015, tom: 31(7), strony: 793-9), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/02656736.2015.1067333 - link to the publication
  2. LPS alters pattern of sickness behavior but does not affect glutathione level in aged male rats.
    Authors:
    Wrotek S, Jedrzejewski T, Nowakowska A, Kozak W.
    Academic press:
    Biogerontology 2016 (rok: 2016, tom: February, strony: 45300), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10522-016-9636-x - link to the publication
  3. Buthionine sulfoximine, a glutathione depletor, attenuates endotoxic fever and reduces IL-1b and IL-6 level in rats
    Authors:
    Sylwia Wrotek, Krzysztof Domagalsk, Tomasz Je˛drzejewski, Eliza Dec, Wiesław Kozak
    Academic press:
    Cytokine (rok: 2017, tom: 90, strony: 31–37), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.005. - link to the publication
  1. Immunological consequences of manipulation in glutathione level
    Authors:
    Sylwia Wrotek, Tomasz Jędrzejewski, Magdalena Wolska, Wiesław Kozak
    Conference:
    The XVIth Congress of the Polish Society of Experimental and Clinical Immunology (rok: 2017, ), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja June 8-10,
    Status:
    Published

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