Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The research of molecular markers for neuroprotective effect of tetrahydroisoquinolines based on various eksperimental models of Parkinson's disease.

2012/07/B/NZ7/01149

Keywords:

Parkinson's disease tetrahydroisoquinolines neuroprotection

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ4_9: Systems neurobiology
  • NZ3_3: Apoptosis

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Wąsik 

Number of co-investigators in the project: 10

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 837 185 PLN

Project start date (Y-m-d): 2013-07-01

Project end date (Y-m-d): 2016-06-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. stolik stereotaktyczny (20 000 PLN)
  2. Detektor spektrofotometryczny UV/VIS (4k) wraz z celką przepływową do detektora (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Comparison of the Effects of Acute and Chronic Administration of Tetrahydroisoquinoline Amines on the In Vivo Dopamine Release: A Microdialysis Study in the Rat Striatum
    Authors:
    Agnieszka Wąsik, Irena Romańska and Lucyna Antkiewicz-Michaluk
    Academic press:
    Neurotoxicity Research (rok: 2016, tom: 30(4), strony: 648-657), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-016-9661-1 - link to the publication
  2. 1.Neuroprotective effect of the endogenous amine 1MeTIQ in an animal model of Parkinson's disease
    Authors:
    Agnieszka Wąsik 1 *, Irena Romańska 1, Jerzy Michaluk 1 , Agnieszka Zelek-Molik2,Irena Nalepa,2 Lucyna Antkiewicz-Michaluk 1
    Academic press:
    Neurotoxicity Research (rok: 2016, tom: 29, strony: 351-363), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-015-9556-6 - link to the publication
  3. Multiple Administration of Endogenous Amines TIQ and 1MeTIQ Protects Against a 6-OHDA-Induced Essential Fall of Dopamine Release in the Rat Striatum: In Vivo Microdialysis Study
    Authors:
    Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Lucyna Antkiewicz-Michaluk
    Academic press:
    Neurotoxicity Research (rok: 2018, tom: 33(3), strony: 523-531), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-017-9824-8 - link to the publication
  4. The impact of 1MeTIQ on the function of dopaminergic system in 6-OHDA model of Parkinson's disease
    Authors:
    20.Agnieszka Wąsik1, Dawid Polak2, Irena Romańska1, Jerzy Michaluk1, Lucyna Antkiewicz-Michaluk1
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68(6), strony: 1205-1213), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2016.08.004 - link to the publication
  5. The mechanism of neuroprotective action of natural compounds
    Authors:
    Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69(5), strony: 851-860), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.03.018 - link to the publication

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