Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Influence of the B cell receptor (BCR) signaling pathways on CD20 levels in tumor cells and antitumor activity of anti-CD20 monclonal antibodies

2012/07/B/NZ6/03498

Keywords:

B-cell receptor (BCR) CD20 antigen monoclonal antibodies

Descriptors:

  • NZ6_8: Other related subjects
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Winiarska 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 786 000 PLN

Project start date (Y-m-d): 2013-06-20

Project end date (Y-m-d): 2016-06-19

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. kompaktowy cytometr (190 000 PLN)
  2. Ława do przygotowania reakcji PCR (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells
    Authors:
    Siernicka M, Winiarska M, Bajor M, Firczuk M, Muchowicz A, Bobrowicz M, Fauriat C, Golab J, Olive D, Zagozdzon R
    Academic press:
    Immunology (rok: 2015, tom: Sep;146(1), strony: 173-83), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/imm.12494 - link to the publication
  2. B-cell receptor signaling in the pathogenesis of lymphoid malignancies
    Authors:
    Kamil Bojarczuk, Malgorzata Bobrowicz, Michal Dwojak, Nina Miazek, Piotr Zapala , Anders Bunes , Marta Siernicka , Maria Różanska, Magdalena Winiarska
    Academic press:
    Blood Cells Mol Dis (rok: 2015, tom: Oct;55(3), strony: 255-65), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcmd.2015.06.016. - link to the publication
  3. Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies
    Authors:
    Magdalena Winiarska, Kamil Bojarczuk, Beata Pyrzynska, Jacek Bil, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Magdalena Krol, Aleksandra Syta, Paulina Podszywalow-Bartnicka, Zofia Pilch, Anna Dabrowska-Iwanicka, Przemyslaw Juszczynski, Dimitar G Efremov, Mikolaj Slabicki, Thorsten Zenz, Aude Le Roy, Daniel Olive, Tomasz P Rygiel, Jeanette HW Leusen, Jakub Golab
    Academic press:
    mAbs (rok: 2014, tom: 5, strony: 1300-1313), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.4161/mabs.32106 - link to the publication
  4. Sorafenib improves rituximab and ofatumumab efficacy by decreasing the expression of complement regulating proteins
    Authors:
    Michal Dwojak, Malgorzata Bobrowicz, Jacek Bil, Kamil Bojarczuk, Beata Pyrzynska, Marta Siernicka, Agata Malenda, Ewa Lech-Maranda, Waldemar Tomczak, Krzysztof Giannopoulos, Jakub Golab, Magdalena Winiarska
    Academic press:
    Blood Cancer Journal (rok: 2015, tom: 45392, strony: e300), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/bcj.2015.27 - link to the publication
  5. B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies
    Authors:
    Kamil Bojarczuk, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Beata Pyrzynska, Pawel Gaj, Marta Karp, Krzysztof Giannopoulos, Dimitar G Efremov, Cyril Fauriat, Jakub Golab, Magdalena Winiarska
    Academic press:
    Leukemia (rok: 2014, tom: 5, strony: 1163-1167), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1038/leu.2014.12 - link to the publication

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