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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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A search for a link between epigenetical changes - active DNA demethylation and oxidative stress based on cell culture studies

2012/07/B/NZ1/00008

Keywords:

active DNA demethylation oxidative stress modified DNA bases gene expression

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Oliński 

Number of co-investigators in the project: 10

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 684 575 PLN

Project start date (Y-m-d): 2013-07-09

Project end date (Y-m-d): 2016-12-08

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Automat do izolacji kwasów nukleinowych (125 000 PLN)
  2. pH-metr laboratoryjny (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (4)
  1. Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
    Authors:
    Ryszard Olinski, Marta Starczak, Daniel Gackowski
    Academic press:
    Mutation Research (rok: 2016, tom: 767, strony: 59-66), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrrev.2016.02.001 - link to the publication
  2. The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation
    Authors:
    Magdalena Skonieczna, Artur Cieślar-Pobuda, Yuriy Saenko, Marek Foksiński, Ryszard Oliński, Joanna Rzeszowska-Wolny, Emilia Wiechec.
    Academic press:
    Medicinal Chemistry (rok: 2017, tom: 13, strony: 45298), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1573406413666170421102353 - link to the publication
  3. Comparison of the Absolute Level of Epigenetic Marks--5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm.
    Authors:
    Jolanta Guz, Daniel Gackowski, Marek Foksinski, Rafal Rozalski, Ryszard Olinski
    Academic press:
    Biology of Reproduction (rok: 2014, tom: 91 (3) 55, strony: 45296), Wydawca: Society for the Study of Reproduction with the assistance of HighWire Press
    Status:
    Published
    DOI:
    10.1095/biolreprod.114.121541 - link to the publication
  4. Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5- Formylcytosine, 5-Carboxylcytosine and 5- Hydroxymethyluracil) and Their Interrelationships
    Authors:
    Daniel Gackowski, Ewelina Zarakowska, Marta Starczak, Martyna Modrzejewska, Ryszard Olinski
    Academic press:
    PLOS ONE (rok: 2015, tom: 10(12), strony: e0144859), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0144859 - link to the publication
  5. Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA
    Authors:
    Modrzejewska M, Gawronski M, Skonieczna M, Zarakowska E, Starczak M, Foksinski M, Rzeszowska-Wolny J, Gackowski D, Olinski R.
    Academic press:
    Free Radical Biology and Medicine (rok: 2016, tom: 101, strony: 378-383), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.535 - link to the publication
  6. NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
    Authors:
    Magdalena Skonieczna , Tomasz Hejmo, Aleksandra Poterala-Hejmo, Artur Cieslar-Pobuda, Rafal J. Buldak
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2017, tom: 2017, strony: 45306), Wydawca: HINDAWI PUBLISHING CORP
    Status:
    Published
    DOI:
    10.1155/2017/9420539 - link to the publication
  7. Oxidation Products of 5-Methyl Cytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice
    Authors:
    Zarakowska E, Czerwinska J, Tupalska A, Yousefzadeh MJ, Gregg SQ, St Croix CM, Niedernhofer LJ, Foksinski M, Gackowski D, Szpila A, Starczak M, Tudek B, Olinski R.
    Academic press:
    J Gerontol A Biol Sci Med Sci. (rok: 2018, ), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/gerona/gly012 - link to the publication
  8. Profiles of a broad spectrum of epigenetic DNA modifications in normal and malignant human cell lines: Proliferation rate is not the major factor responsible for the 5- hydroxymethyl-20-deoxycytidine level in cultured cancerous cell lines
    Authors:
    Marek Foksinski, Ewelina Zarakowska, Daniel Gackowski, Magdalena Skonieczna, Karolina Gajda, Dorota Hudy, Anna Szpila, Karol Bialkowski, Marta Starczak, Anna Labejszo, Jaroslaw Czyz, Joanna Rzeszowska-Wolny, Ryszard Olinski
    Academic press:
    PLOS ONE (rok: 2017, tom: 12, strony: e0195819), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0188856 - link to the publication
  1. 5-METHYLCYTOSINE, 5-HYDROXYMETHYLCYTOSINE AND 5-HYDROXYMETHYLURACIL IN HUMAN LEUKOCYTES AND SPERM AS EPIGENETIC MARKS – COMPARISON OF THE ABSOLUTE LEVEL.
    Authors:
    Jolanta Guz, Daniel Gackowski, Marek Foksinski, Rafal Rozalski, Tomasz Dziaman, Ewelina Zarakowska, Anna Szpila, Ryszard Olinski
    Conference:
    XVIIIth Gliwice Scientific Meetings 2014 (rok: 2014, ), Wydawca: gsn
    Data:
    konferencja 21-22 November 2014
    Status:
    Published
    DOI:
    link to the publication
  2. Changes in plasma ascorbate and 2-ketoglutarate levels among patients with colorectal cancer compared to controls.
    Authors:
    Martyna Modrzejewska, Marek Foksiński, Daniel Gackowski, Marta Starczak, Rafał Różalski, Ewelina Zarakowska, Anna Szpila, Jolanta Guz, Maria Kłopocka, Zbigniew Banaszkiewicz, Ryszard Oliński.
    Conference:
    XIXth Gliwice Scientific Meetings 2015. (rok: 2015, ), Wydawca: gsn
    Data:
    konferencja 20-21 November 2015
    Status:
    Published
  3. INHIBITION OF VOLTAGE-DEPENDENT ANION CHANNELS AND THEIR INFLUENCE ON CELL FUNCTIONING
    Authors:
    Magdalena Skonieczna, Artur Cieślar-Pobuda, Yuriy Saenko, Joanna Rzeszowska-Wolny
    Conference:
    XIXth Gliwice Scientific Meetings 2015 (rok: 2015, ), Wydawca: gsn
    Data:
    konferencja 20-21 November 2015
    Status:
    Published
  4. UVA STIMULATES THE PROLIFERATION OF HUMAN TUMOR CELLS
    Authors:
    Sylwia Kała, Karolina Gajda, Przemyslaw Hahn, Joanna Rzeszowska
    Conference:
    XIXth Gliwice Scientific Meetings 2015 (rok: 2015, ), Wydawca: gsn
    Data:
    konferencja 20-21 November 2015
    Status:
    Published

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