Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Determinants of homocysteine thiolactone in humans

2012/07/B/NZ7/01178

Keywords:

homocysteine thiolactone cardiovascular disease urine

Descriptors:

  • NZ7_1:
  • NZ7_12:
  • NZ5_3:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 4

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 612 300 PLN

Project start date (Y-m-d): 2013-07-02

Project end date (Y-m-d): 2016-07-01

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. 1260 Standard Degasser.
  2. Aparat próżniowy do ekstrakcji na 24 probki firmy J. T. Baker (10 500 PLN)
  3. Zamrażarka na -80 C (36 900 PLN)
  4. Komputer z oprogramowaniem (15 000 PLN)
  5. pH-metr.

Information in the final report

  • Publication in academic press/journals (25)
  • Articles in post-conference publications (21)
  1. Quantification of urinary S- and N-homocysteinylated protein and homocysteine-thiolactone in mice
    Authors:
    Jakubowski H.
    Academic press:
    Anal Biochem (rok: 2016, tom: 508, strony: 118-23), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2016.06.002 - link to the publication
  2. Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography
    Authors:
    Glowacki R, Stachniuk J, Borowczyk K, Jakubowski H.
    Academic press:
    Analytical Bioanalytical Chemistry (rok: 2016, tom: 408, strony: 1935-1941), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-016-9308-3 - link to the publication
  3. l-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats
    Authors:
    Bogdański P, Suliburska J, Szulińska M, Sikora M, Walkowiak J, Jakubowski H.
    Academic press:
    Biomedicine Pharmacotherapy (rok: 2015, tom: 76, strony: 100-106), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.001 - link to the publication
  4. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease
    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 113, strony: 200-6), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 - link to the publication
  5. Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells
    Authors:
    Gurda D, Handschuh L, Kotkowiak W, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2015, tom: 47, strony: 319-39), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-015-1956-7 - link to the publication
  6. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis (rok: 2014, tom: 42, strony: 247-260), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 - link to the publication
  7. The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system
    Authors:
    Drabowicz J, Jakubowski H, Kudzin MH, Kudzin ZH.
    Academic press:
    Acta Biochim Pol (rok: 2015, tom: 62, strony: 139-50), Wydawca: Polskie Towarzystwo Biochmiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2014_904 - link to the publication
  8. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (rok: 2014, tom: 40, strony: 713-26), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132033 - link to the publication
  9. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease
    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 112, strony: 339-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 - link to the publication
  10. The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system
    Authors:
    Drabowicz J, Jakubowski H, Kudzin MH, Kudzin ZH.
    Academic press:
    Acta Biochim Pol (rok: 2015, tom: 62, strony: 139-50), Wydawca: Polskie Towarzystwo Biochmiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2014_904 - link to the publication
  11. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (rok: 2014, tom: 40, strony: 713-26), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132033 - link to the publication
  12. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities
    Authors:
    Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.
    Academic press:
    FASEB J (rok: 2016, tom: xx, strony: xx), Wydawca: Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.201600539 - link to the publication
  13. Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World.
    Authors:
    Jakubowski H.
    Academic press:
    FEBS Lett. (rok: 2016, tom: 590, strony: 469-481), Wydawca: Viley
    Status:
    Published
    DOI:
    10.1002/1873-3468.12085 - link to the publication
  14. Paraoxonase 1 deficiency and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis. 2014 Oct 29
    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol. (rok: 2014, tom: 61, strony: 815-23), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    brak - link to the publication
  15. Identification of N-homocysteinylation sites in plasma proteins
    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2014, tom: 46, strony: 235-44), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 - link to the publication
  16. Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells
    Authors:
    Gurda D, Handschuh L, Kotkowiak W, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2015, tom: 47, strony: 319-39), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-015-1956-7 - link to the publication
  17. Paraoxonase 1 deficiency and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis. 2014 Oct 29
    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol. (rok: 2014, tom: 61, strony: 815-23), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
  18. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis (rok: 2014, tom: 42, strony: 247-260), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 - link to the publication
  19. Effects of endurance and endurance–strength exercise on biochemical parameters of liver function in women with abdominal obesity
    Authors:
    Skrypnik D, Ratajczak M, Karolkiewicz J, Mądry E, Pupek-Musialik D, Hansdorfer-Korzond R, Walkowiak J, Jakubowski H, Bogdański P.
    Academic press:
    Biomed Pharmacother (rok: 2016, tom: 80, strony: 45664), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2016.02.017 - link to the publication
  20. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
    Authors:
    Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2014, tom: 46, strony: 1471-80), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-014-1712-4 - link to the publication
  21. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease
    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 113, strony: 200-6), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 - link to the publication
  22. Identification of N-homocysteinylation sites in plasma proteins
    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2014, tom: 46, strony: 235-44), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 - link to the publication
  23. Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World.
    Authors:
    Jakubowski H.
    Academic press:
    FEBS Lett. (rok: 2016, tom: 590, strony: 469-481), Wydawca: Viley
    Status:
    Published
    DOI:
    10.1002/1873-3468.12085 - link to the publication
  24. Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography
    Authors:
    Glowacki R, Stachniuk J, Borowczyk K, Jakubowski H.
    Academic press:
    Analytical Bioanalytical Chemistry (rok: 2016, tom: 408, strony: 1935-1941), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-016-9308-3 - link to the publication
  25. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease
    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 112, strony: 339-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 - link to the publication
  1. Identification of 2-pyridoxyl-1,3-thiazolidine-4-carboxylic acid, novel metabolite of witamin B6 and cysteine in human plasma
    Authors:
    R. Głowacki, M. Wyszczelska-Rokiel, H. Jakubowski
    Conference:
    BIO 2014 Congress, Warsaw, Poland (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12 September
    Status:
    Published
  2. Paraoxonase 1 (Pon1) regulates water homeostasis by controlling the expression of Fxr and Aqp2 proteins in mice
    Authors:
    Wieloch M, Jakubowski H.
    Conference:
    29th Annual Symposium of the Protein-Society (rok: 2015, ), Wydawca: Wiley
    Data:
    konferencja 22-25.07.2015
    Status:
    Published
  3. Correlations between sulfur-containing amino acids and albumin in human plasma
    Authors:
    Borowczyk K, Jakubowski H, Glowacki R.
    Conference:
    10th International conference One Carbon Metabolism (rok: 2015, ), Wydawca: Medical School, University of Lorraine
    Data:
    konferencja 7-11.07.2015
    Status:
    Published
  4. N-homocysteinylation as a mechanism of connective tissue impairment in hyperhomocysteinemia due to cystathionine β-synthase deficiency
    Authors:
    Perła-Kajan J, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  5. Homocysteine-thiolactone and cardiovascular disease in B-vitamin trials
    Authors:
    Borowczyk K, Glowacki R, Nygard O, Jakubowski H
    Conference:
    10th International conference One Carbon Metabolism (rok: 2015, ), Wydawca: Medical School, University of Lorraine, Nancy
    Data:
    konferencja 7-11.07.2015
    Status:
    Published
  6. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  7. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  8. Inactivation of the bleomycin hydrolase (Blmh) gene affects the expression of glyoxylase domain containing protein 4 (Glod4) gene in mice
    Authors:
    Utyro O, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  9. Tissue-specific effect of hyperhomocysteinemia on collagen and elastin cross-links in a cystathionine beta-synthase-deficient mouse
    Authors:
    Perla-Kajan, J, Ogrodna, K, Jakubowski H.
    Conference:
    14th International Congress on Amino Acids, Peptides and Protein (rok: 2016, ), Wydawca: Springer, Amino Acids
    Data:
    konferencja 3-7.08.2015
    Status:
    Published
  10. Identification of N-homocysteinylation sites in mouse plasma albumin and hemoglobin from cystathionine β-synthase deficient mice
    Authors:
    Sikora M, Marczak L, Jakubowski H.
    Conference:
    10th International conference One Carbon Metabolism (rok: 2015, ), Wydawca: Medical School, University of Lorraine, Nancy, Francja
    Data:
    konferencja 7.11.2015
    Status:
    Published
  11. N-homocysteinylation as a mechanism of connective tissue impairment in hyperhomocysteinemia due to cystathionine β-synthase deficiency
    Authors:
    Perła-Kajan J, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  12. Inactivation of the bleomycin hydrolase (Blmh) gene affects the expression of glyoxylase domain containing protein 4 (Glod4) gene in mice
    Authors:
    Utyro O, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  13. Cystathionine β-synthase deficiency changes expression of major urinary proteins in mice
    Authors:
    Wróblewski J, Perła-Kaján J, Wyszczelska-Rokiel M, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  14. Properties of fibrin clots formed from plasma of CBS-deficient patients and their unaffected family members
    Authors:
    Bielińska I, Sikora M, Perła-Kajan J, Ząbczyk M, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  15. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  16. Does hyperhomocysteinemia affect collagen and elastin cross-links in a mouse model of cystathionine β-synthase deficiency?
    Authors:
    Perła-Kaján J, Ogrodna K, Jakubowski H.
    Conference:
    10th International conference One Carbon Metabolism (rok: 2015, ), Wydawca: Medical School, University of Lorraine, Nancy
    Data:
    konferencja 7-11.07.2015
    Status:
    Published
  17. Paraoxonase 1 (Pon1) regulates water homeostasis by controlling the expression of Fxr and Aqp2 proteins in mice
    Authors:
    Wieloch M, Jakubowski H.
    Conference:
    29th Annual Symposium of the Protein-Society (rok: 2015, ), Wydawca: Wiley
    Data:
    konferencja 22-25.07.2015
    Status:
    Published
  18. Does hyperhomocysteinemia affect collagen and elastin cross-links in a mouse model of cystathionine β-synthase deficiency?
    Authors:
    Perła-Kaján J, Ogrodna K, Jakubowski H.
    Conference:
    10th International conference One Carbon Metabolism (rok: 2015, ), Wydawca: Medical School, University of Lorraine, Nancy
    Data:
    konferencja 7-11.07.2015
    Status:
    Published
  19. Histones are targeted for N-homocysteinylation in human endothelial cells
    Authors:
    Gurda D, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published
  20. Identification of N-homocysteinylation sites in mouse plasma albumin and hemoglobin from cystathionine β-synthase deficient mice
    Authors:
    Sikora M, Marczak L, Jakubowski H.
    Conference:
    10th International conference One Carbon Metabolism (rok: 2015, ), Wydawca: Medical School, University of Lorraine, Nancy, Francja
    Data:
    konferencja 7.11.2015
    Status:
    Published
  21. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 9-12.09
    Status:
    Published

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