Zmiana języka

Projects search

Determinants of homocysteine thiolactone in humans

2012/07/B/NZ7/01178

Keywords

Descriptors

  • NZ7_1: Epidemiologia
  • NZ7_12: Prewencja chorób człowieka
  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Hieronim Jakubowski

Number of co-investigators in the project: 4

Call

OPUS 4 – announced on 2012-09-15

Amount awarded
612 300 PLN
Project start date
2013-07-02
Project end date
2016-07-01
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. 1260 Standard Degasser.
  2. Aparat próżniowy do ekstrakcji na 24 probki firmy J. T. Baker. Cost: 10 500 PLN
  3. Komputer z oprogramowaniem. Cost: 15 000 PLN
  4. Zamrażarka na -80 C. Cost: 36 900 PLN
  5. pH-metr.

Information in the final report

Publication in academic press/journals (15)

  1. Paraoxonase 1 deficiency and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis. 2014 Oct 29

    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol. (year: 2014, volume: 61, pages: 815-23), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published

  2. Effects of endurance and endurance–strength exercise on biochemical parameters of liver function in women with abdominal obesity

    Authors:
    Skrypnik D, Ratajczak M, Karolkiewicz J, Mądry E, Pupek-Musialik D, Hansdorfer-Korzond R, Walkowiak J, Jakubowski H, Bogdański P.
    Academic press:
    Biomed Pharmacother (year: 2016, volume: 80, pages: 46029), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2016.02.017 – link to the publication

  3. Quantification of urinary S- and N-homocysteinylated protein and homocysteine-thiolactone in mice

    Authors:
    Jakubowski H.
    Academic press:
    Anal Biochem (year: 2016, volume: 508, pages: 118-23), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2016.06.002 – link to the publication

  4. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities

    Authors:
    Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.
    Academic press:
    FASEB J (year: 2016, volume: xx, pages: xx), Publisher: Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.201600539 – link to the publication

  5. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration

    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis (year: 2014, volume: 42, pages: 247-260), Publisher: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 – link to the publication

  6. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration

    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (year: 2014, volume: 40, pages: 713-26), Publisher: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132033 – link to the publication

  7. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis

    Authors:
    Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    Amino Acids (year: 2014, volume: 46, pages: 1471-80), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-014-1712-4 – link to the publication

  8. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease

    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab (year: 2014, volume: 113, pages: 200-6), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 – link to the publication

  9. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease

    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (year: 2014, volume: 112, pages: 339-46), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 – link to the publication

  10. Identification of N-homocysteinylation sites in plasma proteins

    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Amino Acids (year: 2014, volume: 46, pages: 235-44), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 – link to the publication

  11. Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography

    Authors:
    Glowacki R, Stachniuk J, Borowczyk K, Jakubowski H.
    Academic press:
    Analytical Bioanalytical Chemistry (year: 2016, volume: 408, pages: 1935-1941), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-016-9308-3 – link to the publication

  12. Aminoacyl-tRNA Synthetases and the Evolution of Coded Peptide Synthesis: The Thioester World.

    Authors:
    Jakubowski H.
    Academic press:
    FEBS Lett. (year: 2016, volume: 590, pages: 469-481), Publisher: Viley
    Status:
    Published
    DOI:
    10.1002/1873-3468.12085 – link to the publication

  13. l-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats

    Authors:
    Bogdański P, Suliburska J, Szulińska M, Sikora M, Walkowiak J, Jakubowski H.
    Academic press:
    Biomedicine Pharmacotherapy (year: 2015, volume: 76, pages: 100-106), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2015.10.001 – link to the publication

  14. The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system

    Authors:
    Drabowicz J, Jakubowski H, Kudzin MH, Kudzin ZH.
    Academic press:
    Acta Biochim Pol (year: 2015, volume: 62, pages: 139-50), Publisher: Polskie Towarzystwo Biochmiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2014_904 – link to the publication

  15. Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

    Authors:
    Gurda D, Handschuh L, Kotkowiak W, Jakubowski H.
    Academic press:
    Amino Acids (year: 2015, volume: 47, pages: 319-39), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-015-1956-7 – link to the publication

Articles in post-conference publications (14)

  1. Paraoxonase 1 (Pon1) regulates water homeostasis by controlling the expression of Fxr and Aqp2 proteins in mice

    Authors:
    Wieloch M, Jakubowski H.
    Conference:
    29th Annual Symposium of the Protein-Society (year: 2015, pages: Protein Science 2015;24(Suppl 1):289-290), Publisher: Wiley
    Date:
    conference 22-25.07.2015
    Status:
    Published

  2. Identification of 2-pyridoxyl-1,3-thiazolidine-4-carboxylic acid, novel metabolite of witamin B6 and cysteine in human plasma

    Authors:
    R. Głowacki, M. Wyszczelska-Rokiel, H. Jakubowski
    Conference:
    BIO 2014 Congress, Warsaw, Poland (year: 2014, pages: 244), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12 September
    Status:
    Published

  3. Cystathionine β-synthase deficiency changes expression of major urinary proteins in mice

    Authors:
    Wróblewski J, Perła-Kaján J, Wyszczelska-Rokiel M, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (year: 2014, pages: 219), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  4. Properties of fibrin clots formed from plasma of CBS-deficient patients and their unaffected family members

    Authors:
    Bielińska I, Sikora M, Perła-Kajan J, Ząbczyk M, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (year: 2014, pages: 113), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  5. Identification of N-homocysteinylation sites in mouse plasma albumin and hemoglobin from cystathionine β-synthase deficient mice

    Authors:
    Sikora M, Marczak L, Jakubowski H.
    Conference:
    10th International conference One Carbon Metabolism (year: 2015, pages: 67-68), Publisher: Medical School, University of Lorraine, Nancy, Francja
    Date:
    conference 7.11.2015
    Status:
    Published

  6. Histones are targeted for N-homocysteinylation in human endothelial cells

    Authors:
    Gurda D, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (year: 2014, pages: 120), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  7. Inactivation of the bleomycin hydrolase (Blmh) gene affects the expression of glyoxylase domain containing protein 4 (Glod4) gene in mice

    Authors:
    Utyro O, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (year: 2014, pages: 133), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  8. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration

    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (year: 2014, pages: 176), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  9. Tissue-specific effect of hyperhomocysteinemia on collagen and elastin cross-links in a cystathionine beta-synthase-deficient mouse

    Authors:
    Perla-Kajan, J, Ogrodna, K, Jakubowski H.
    Conference:
    14th International Congress on Amino Acids, Peptides and Protein (year: 2016, pages: 48(2):635-635), Publisher: Springer, Amino Acids
    Date:
    conference 3-7.08.2015
    Status:
    Published

  10. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration

    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014, Warsaw (year: 2014, pages: 186), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  11. Does hyperhomocysteinemia affect collagen and elastin cross-links in a mouse model of cystathionine β-synthase deficiency?

    Authors:
    Perła-Kaján J, Ogrodna K, Jakubowski H.
    Conference:
    10th International conference One Carbon Metabolism (year: 2015, pages: 23), Publisher: Medical School, University of Lorraine, Nancy
    Date:
    conference 7-11.07.2015
    Status:
    Published

  12. Homocysteine-thiolactone and cardiovascular disease in B-vitamin trials

    Authors:
    Borowczyk K, Glowacki R, Nygard O, Jakubowski H
    Conference:
    10th International conference One Carbon Metabolism (year: 2015, pages: 51-52), Publisher: Medical School, University of Lorraine, Nancy
    Date:
    conference 7-11.07.2015
    Status:
    Published

  13. N-homocysteinylation as a mechanism of connective tissue impairment in hyperhomocysteinemia due to cystathionine β-synthase deficiency

    Authors:
    Perła-Kajan J, Jakubowski H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (year: 2014, pages: 128), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 9-12.09
    Status:
    Published

  14. Correlations between sulfur-containing amino acids and albumin in human plasma

    Authors:
    Borowczyk K, Jakubowski H, Glowacki R.
    Conference:
    10th International conference One Carbon Metabolism (year: 2015, pages: 64-65), Publisher: Medical School, University of Lorraine
    Date:
    conference 7-11.07.2015
    Status:
    Published

« New search

Graphic design and implementation: Jakub Piotrowski