Projects funded by the NCN
Pronucloetides - a pathway to cellular DNA sensitization to ionizing radiation
2012/07/N/ST5/01877
Keywords:
modified nucleobases and nucleosides cycloSal method DNA sensitization
Descriptors:
- ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
- ST5_16:
- ST5_23:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Uniwersytet Gdański, Wydział Chemii
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: PRELUDIUM 4 - announced on 2012-09-15
Amount awarded: 148 717 PLN
Project start date (Y-m-d): 2013-08-20
Project end date (Y-m-d): 2016-08-19
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Komora laminarna (np. Biosan UVC/T-B-AR - Biotech: www.biotech-polska.pl) (8 118 PLN)
- Inkubator CO2 ( Binder C 150 – Biotech: www.biotech-polska.pl) (24 477 PLN)
- Łaźnia wodna.
- Mikroskop (np. OPTICA B-353PL – Biotech: www.biotech-polska.pl) (4 957 PLN)
Information in the final report
- Publication in academic press/journals (3)
- 5-Thiocyanato-20-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerizationAuthors:Magdalena Zdrowowicz, Lidia Chomicz, Michał Żyndul, Paweł Wityk, Janusz Rak,Tyler J. Wiegand, Cameron G. Hanson, Amitava Adhikary, Michael D. SevillaAcademic press:Physical Chemistry Chemical Physics (rok: 2015, tom: 17, strony: 16907), Wydawca: Royal Society Of ChemistryStatus:PublishedDOI:10.1039/c5cp02081f - link to the publication
- Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV RadiationAuthors:Janusz Rak, Lidia Chomicz, Justyna Wiczk, Kinga Westphal, Magdalena Zdrowowicz, Paweł Wityk, Michał Żyndul, Samanta Makurat, Łukasz GolonAcademic press:The Journal of Physical Chemistry B (rok: 2015, tom: 119, strony: 8227-8238), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.jpcb.5b03948 - link to the publication
- How to Find Out Whether a 5-Substituted Uracil Could Be a Potential DNA RadiosensitizerAuthors:Lidia Chomicz, Magdalena Zdrowowicz, Franciszek Kasprzykowski, Janusz Rak, Angela Buonaugurio, Yi Wang, Kit H. BowenAcademic press:The Journal of Physical Chemistry Letters (rok: 2013, tom: 4 (17), strony: 2853-2857), Wydawca: ACS PublicationsStatus:PublishedDOI:10.1021/jz401358w - link to the publication