Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The study on the impact of the metabolism of salinomycin on its toxicity

2012/07/D/NZ7/03387

Keywords:

salinomycin ionophore antibiotics cytotoxicity metabolites mass spectrometry

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_11: Veterinary healthcare

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Olejnik 

Number of co-investigators in the project: 4

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 475 700 PLN

Project start date (Y-m-d): 2013-08-13

Project end date (Y-m-d): 2017-08-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa perystaltyczna (8 000 PLN)
  2. Oprogramowanie LightSight.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Cytotoxicity of anticancer candidate salinomycin and identification of its metabolites in rat cell cultures
    Authors:
    Lidia Radko, Małgorzata Olejnik
    Academic press:
    Toxicology in Vitro (rok: 2018, tom: 52, strony: 314-320), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2018.07.006 - link to the publication
  2. Identification of metabolites of antivancer candidate salinomycin using Q-TOF and hybrid QQQ-linear ion trap mass spectrometry
    Authors:
    Małgorzata Olejnik, Lidia Radko, Piotr Jedziniak
    Academic press:
    Rapid Communications in Mass Spectrometry (rok: 2018, tom: 32, strony: 629-634), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/rcm.8082 - link to the publication
  1. Cytotoxicity evaluation of salinomycin and identification of its metabolites in two rat cellular models
    Authors:
    Lidia Radko, Małgorzata Olejnik, Beata Korycińska
    Conference:
    51st Congress of the European Societies of Toxicology (EUROTOX) (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16 września 2015
    Status:
    Published
  2. Identification of metabolites of polyether antibiotic salinomycin using Q-TOF and hybrid QqQ-linear ion trap
    Authors:
    Małgorzata Olejnik, Lidia Radko, Beata Korycińska, Piotr Jedziniak
    Conference:
    33rd Informal Meeting on Mass Spectrometry (rok: 2015, ), Wydawca: Polskie Towarzystwo Spektrometrii Mas
    Data:
    konferencja 10-13 maja 2015
    Status:
    Published
  3. Badanie cytotoksyczności i biotransformacji salinomycyny z wykorzystaniem linii hepatoma i hepatocytów pierwotnych
    Authors:
    Małgorzata Olejnik, Lidia Radko
    Conference:
    XII Konferencja Szkoleniowo-Naukowa Polskiego Towarzystwa Toksykologicznego "Różne oblicza toksykologii" (rok: 2017, ), Wydawca: Oddział Lubelski Polskiego Towarzystwa Toksykologicznego
    Data:
    konferencja 19-22 września 2017
    Status:
    Published
  4. Assessment of cytotoxicity and metabolism of salinomycin in two mammalian cell cultures
    Authors:
    Małgorzata Olejnik, Lidia Radko
    Conference:
    51st Congress of the European Societies of Toxicology (EUROTOX) (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16 września 2015
    Status:
    Published