"Epigenetic mechanisms underlying cocaine seeking and relapse"
2012/06/A/NZ3/00022
Keywords
Descriptors
- NZ3_5: Neurobiologia molekularna
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Instytut Farmakologii PAN
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 10
Call
MAESTRO 3 – announced on 2012-06-15
- Amount awarded
- 2 997 790 PLN
- Project start date
- 2013-04-09
- Project end date
- 2020-04-08
- Project duration
- 84 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Aparat do elektroforezy poziomej. Cost: 5 000 PLN
- Homogonizator. Cost: 15 000 PLN
- Sonifikator. Cost: 20 000 PLN
- Termoblok. Cost: 10 000 PLN
- Termocykler.
Information in the final report
Publication in academic press/journals (11)
-
Increased 5-hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self-administration
- Authors:
- Anna Sadakierska-Chudy, Małgorzata Frankowska, Karolina Wydra, Joanna Jastrzębska, Joanna Miszkiel, Małgorzata Filip
- Academic press:
- Hippocampus (year: 2017, volume: 27, pages: 811-821), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/hipo.22733 – link to the publication
-
A Comprehensive View of the Epigenetic Landscape. Part II: Histone Post-translational Modification, Nucleosome Level, and Chromatin Regulation by ncRNAs.
- Authors:
- Sadakierska-Chudy A, Filip M.
- Academic press:
- Neurotoxicity Research (year: 2015, volume: 27, pages: 172-197), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12640-014-9508-6 – link to the publication
-
Cocaine administration and its withdrawal enhance the expression of genes encoding histone-modifying enzymes and histone acetylation in the rat prefrontal cortex
- Authors:
- Anna Sadakierska-Chudy, Małgorzata Frankowska, Joanna Jastrzebska, Karolina Wydra, Joanna Miszkiel, Marek Sanak, Małgorzata Filip
- Academic press:
- Neurotoxicity Research (year: 2017, volume: 32, pages: 141-150), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12640-017-9728-7 – link to the publication
-
The Alterations in Mitochondrial DNA Copy Number and Nuclear-Encoded Mitochondrial Genes in Rat Brain Structures after Cocaine Self-Administration
- Authors:
- Anna Sadakierska-Chudy, Agnieszka Kotarska, Małgorzata Frankowska, Joanna Jastrzębska, Karolina Wydra, Joanna Miszkiel, Edmund Przegaliński, Małgorzata Filip
- Academic press:
- Molecular Neurobiology (year: 2017, volume: 54, pages: 7460-7470), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12035-016-0153-3 – link to the publication
-
Mitoepigenetics and drug addiction
- Authors:
- Anna Sadakierska-Chudy, Małgorzata Filip
- Academic press:
- Pharmacology & Therapeutics (year: 2014, volume: 144, pages: 226-233), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.pharmthera.2014.06.002 – link to the publication
-
A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
- Authors:
- Sadakierska-Chudy A, Kostrzewa RM, Filip M.
- Academic press:
- Neurotoxicity Research (year: 2015, volume: 27, pages: 84-97), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12640-014-9497-5 – link to the publication
-
Cocaine attenuates acid sphingomyelinase activity during establishment of addiction-related behavior – a translational study in rats and monkeys
- Authors:
- Frankowska, Malgorzata; Jesus, Fernando; Mühle, Christiane; Pacheco, Jessica; Maior, Rafael; Sadakierska-Chudy, Anna; Smaga, Irena; Piechota, Marcin; Kalinichenko, Liubov; Gulbins, Erich; Kornhuber, Johannes; Filip, Małgorzata ; Müller, Christian; Barros, Marilia
- Academic press:
- Addiction Biology (year: 2020, volume: 0, pages: e12955), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1111/adb.12955 – link to the publication
-
Extinction Training after Cocaine Self-Administration Influences the Epigenetic and Genetic Machinery Responsible for Glutamatergic Transporter Gene Expression in Male Rat Brain
- Authors:
- Irena Smaga, Kinga Gawlińska, Małgorzata Frankowska, Karolina Wydra, Anna Sadakierska-Chudy, Agata Suder, Marcin Piechota, Małgorzata Filip
- Academic press:
- Neuroscience (year: 2020, volume: 451, pages: 99-110), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.neuroscience.2020.10.001 – link to the publication
-
The rat brain transcripts after cocaine abstinence and relapse: data from the Maj Institute of Pharmacology Polish Academy of Sciences
- Authors:
- M. Piechota; A. Sadakierska-Chudy; M. Korostyński; M. Frankowska; M. Filip
- Academic press:
- Zenodo (year: 2020, volume: 0, pages: 0), Publisher: Zenodo
- Status:
- Published
- DOI:
- 10.5281/zenodo.3876144 – link to the publication
-
Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia
- Authors:
- Kinga Gawlińska 1 , Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Filip
- Academic press:
- International Journal Molecular Sciences (year: 2020, volume: 21, pages: 7970), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms21217970. – link to the publication
-
Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration
- Authors:
- Sadakierska-Chudy A, Frankowska M, Miszkiel J, Wydra K, Jastrzębska J, Filip M.
- Academic press:
- Molecular Neurobiology (year: 2017, volume: 54, pages: 2241-2254), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12035-016-9817-2 – link to the publication
Articles in post-conference publications (4)
-
Changes in DNA methylation in the rat brain structures after cocaine self-administration
- Authors:
- Sadakierska-Chudy A., Przegalinski E., Filip M.
- Conference:
- 22nd SNIP Scientific Conference (year: 2016, pages: 46211), Publisher: SNIP
- Date:
- conference 6-9.04
- Status:
- Published
-
Effects of cocaine extinction training on the rat hippocampal transcriptome
- Authors:
- Sadakierska-Chudy A., Frankowska M., Jastrzebska J., Wydra K., Miszkiel J., Przegalinski E., Filip M.
- Conference:
- 51st Congress of the European-Societies-of-Toxicology (EUROTOX) (year: 2015, pages: P10-023), Publisher: Elsevier
- Date:
- conference 13-16 September
- Status:
- Published
-
Hippocampal DNA methylation in rat cocaine self-administration model
- Authors:
- Sadakierska-Chudy A., Frankowska M., Jastrzebska J., Wydra K., Miszkiel J., Filip M.
- Conference:
- 51st Congress of the European-Societies-of-Toxicology (EUROTOX) (year: 2015, pages: P10=021), Publisher: Elsevier
- Date:
- conference 13-16 September
- Status:
- Published
-
Prolonged induction of gene expression in rat striatum by cocaine self-administration
- Authors:
- Sadakierska-Chudy A., Frankowska M., Miszkiel J., Nowak E., Filip M.
- Conference:
- 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) (year: 2014, pages: P.6.c.010), Publisher: Elsevier
- Date:
- conference 18-21 October
- Status:
- Published