Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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"Epigenetic mechanisms underlying cocaine seeking and relapse"

2012/06/A/NZ3/00022

Keywords:

DNA methylation histone modification cocaine self-administration rats yoked procedure

Descriptors:

  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Filip 

Number of co-investigators in the project: 10

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 2 997 790 PLN

Project start date (Y-m-d): 2013-04-09

Project end date (Y-m-d): 2020-04-08

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termoblok (10 000 PLN)
  2. Termocykler.
  3. Homogonizator (15 000 PLN)
  4. Sonifikator (20 000 PLN)
  5. Aparat do elektroforezy poziomej (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (4)
  1. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia
    Authors:
    Kinga Gawlińska 1 , Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Filip
    Academic press:
    International Journal Molecular Sciences (rok: 2020, tom: 21, strony: 7970), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21217970. - link to the publication
  2. Extinction Training after Cocaine Self-Administration Influences the Epigenetic and Genetic Machinery Responsible for Glutamatergic Transporter Gene Expression in Male Rat Brain
    Authors:
    Irena Smaga, Kinga Gawlińska, Małgorzata Frankowska, Karolina Wydra, Anna Sadakierska-Chudy, Agata Suder, Marcin Piechota, Małgorzata Filip
    Academic press:
    Neuroscience (rok: 2020, tom: 451, strony: 99-110), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.001 - link to the publication
  3. Mitoepigenetics and drug addiction
    Authors:
    Anna Sadakierska-Chudy, Małgorzata Filip
    Academic press:
    Pharmacology & Therapeutics (rok: 2014, tom: 144, strony: 226-233), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharmthera.2014.06.002 - link to the publication
  4. The rat brain transcripts after cocaine abstinence and relapse: data from the Maj Institute of Pharmacology Polish Academy of Sciences
    Authors:
    M. Piechota; A. Sadakierska-Chudy; M. Korostyński; M. Frankowska; M. Filip
    Academic press:
    Zenodo (rok: 2020, ), Wydawca: Zenodo
    Status:
    Published
    DOI:
    10.5281/zenodo.3876144 - link to the publication
  5. COCAINE ABSTINENCE MODULATES NMDA RECEPTOR SUBUNIT EXPRESSION: AN ANALYSIS OF THE GLUN2B SUBUNIT IN COCAINE-SEEKING BEHAVIOR.
    Authors:
    Irena Smaga, Karolina Wydra, Marcin Piechota, Lucia Caffino, Fabio Fumagalli, Marek Sanak, Małgorzata Filip
    Academic press:
    Prog. Neuropsychopharmacol. Biol. Psychiatry (rok: 2020, ), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
    Authors:
    Sadakierska-Chudy A, Kostrzewa RM, Filip M.
    Academic press:
    Neurotoxicity Research (rok: 2015, tom: 27, strony: 84-97), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-014-9497-5 - link to the publication
  7. The Alterations in Mitochondrial DNA Copy Number and Nuclear-Encoded Mitochondrial Genes in Rat Brain Structures after Cocaine Self-Administration
    Authors:
    Anna Sadakierska-Chudy, Agnieszka Kotarska, Małgorzata Frankowska, Joanna Jastrzębska, Karolina Wydra, Joanna Miszkiel, Edmund Przegaliński, Małgorzata Filip
    Academic press:
    Molecular Neurobiology (rok: 2017, tom: 54, strony: 7460-7470), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-016-0153-3 - link to the publication
  8. Cocaine attenuates acid sphingomyelinase activity during establishment of addiction-related behavior – a translational study in rats and monkeys
    Authors:
    Frankowska, Malgorzata; Jesus, Fernando; Mühle, Christiane; Pacheco, Jessica; Maior, Rafael; Sadakierska-Chudy, Anna; Smaga, Irena; Piechota, Marcin; Kalinichenko, Liubov; Gulbins, Erich; Kornhuber, Johannes; Filip, Małgorzata ; Müller, Christian; Barros, Marilia
    Academic press:
    Addiction Biology (rok: 2020, ), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/adb.12955 - link to the publication
  9. Increased 5-hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self-administration
    Authors:
    Anna Sadakierska-Chudy, Małgorzata Frankowska, Karolina Wydra, Joanna Jastrzębska, Joanna Miszkiel, Małgorzata Filip
    Academic press:
    Hippocampus (rok: 2017, tom: 27, strony: 811-821), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/hipo.22733 - link to the publication
  10. A Comprehensive View of the Epigenetic Landscape. Part II: Histone Post-translational Modification, Nucleosome Level, and Chromatin Regulation by ncRNAs.
    Authors:
    Sadakierska-Chudy A, Filip M.
    Academic press:
    Neurotoxicity Research (rok: 2015, tom: 27, strony: 172-197), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-014-9508-6 - link to the publication
  11. Cocaine administration and its withdrawal enhance the expression of genes encoding histone-modifying enzymes and histone acetylation in the rat prefrontal cortex
    Authors:
    Anna Sadakierska-Chudy, Małgorzata Frankowska, Joanna Jastrzebska, Karolina Wydra, Joanna Miszkiel, Marek Sanak, Małgorzata Filip
    Academic press:
    Neurotoxicity Research (rok: 2017, tom: 32, strony: 141-150), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-017-9728-7 - link to the publication
  12. Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration
    Authors:
    Sadakierska-Chudy A, Frankowska M, Miszkiel J, Wydra K, Jastrzębska J, Filip M.
    Academic press:
    Molecular Neurobiology (rok: 2017, tom: 54, strony: 2241-2254), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-016-9817-2 - link to the publication
  1. Prolonged induction of gene expression in rat striatum by cocaine self-administration
    Authors:
    Sadakierska-Chudy A., Frankowska M., Miszkiel J., Nowak E., Filip M.
    Conference:
    27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) (rok: 2014, ), Wydawca: Elsevier
    Data:
    konferencja 18-21 October
    Status:
    Published
  2. Changes in DNA methylation in the rat brain structures after cocaine self-administration
    Authors:
    Sadakierska-Chudy A., Przegalinski E., Filip M.
    Conference:
    22nd SNIP Scientific Conference (rok: 2016, ), Wydawca: SNIP
    Data:
    konferencja 6-9.04
    Status:
    Published
  3. Hippocampal DNA methylation in rat cocaine self-administration model
    Authors:
    Sadakierska-Chudy A., Frankowska M., Jastrzebska J., Wydra K., Miszkiel J., Filip M.
    Conference:
    51st Congress of the European-Societies-of-Toxicology (EUROTOX) (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16 September
    Status:
    Published
  4. Effects of cocaine extinction training on the rat hippocampal transcriptome
    Authors:
    Sadakierska-Chudy A., Frankowska M., Jastrzebska J., Wydra K., Miszkiel J., Przegalinski E., Filip M.
    Conference:
    51st Congress of the European-Societies-of-Toxicology (EUROTOX) (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16 September
    Status:
    Published

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