Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of microRNAs and inflammation in injury and regeneration of skeletal muscles in Duchenne muscular dystrophy

2012/06/A/NZ1/00004

Keywords:

microRNA miR-378 miR-146a myoblasts satellite cells heme oxygenase-1 Nrf2 induced pluripotent stem cells

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology
  • NZ3_8: Stem cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Józef Dulak 

Number of co-investigators in the project: 8

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 2 988 100 PLN

Project start date (Y-m-d): 2013-04-22

Project end date (Y-m-d): 2018-11-21

Project duration:: 67 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. mikroskop.
  2. bieżnia do badania wydolności mięśni myszy (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  1. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
    Authors:
    Łoboda Agnieszka , Damulewicz M, Pyza E, Józkowicz Alicja , Dulak Józef
    Academic press:
    3.Cellular and Molecular Life Sciences (rok: 2016, tom: 73, strony: 3221-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2223-0 - link to the publication
  2. The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes.
    Authors:
    Kozakowska M, Pietraszek-Gremplewicz K, Jozkowicz A, Dulak J.
    Academic press:
    J Muscle Res Cell Motil (rok: 2015, tom: 36, strony: 377-393), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10974-015-9438-9 - link to the publication
  3. Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation.
    Authors:
    Jez M, Ciesla M, Stepniewski J, Langrzyk A, Muchova L, Vitek L, Jozkowicz A, Dulak J.
    Academic press:
    Biochem Biophys Res Commun. (rok: 2017, tom: 485, strony: 1601-166), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2017.02.041. - link to the publication
  4. Novel faces of heme oxygenase-1: mechanisms and therapeutic potentials
    Authors:
    Józef Dulak, Alicja Józkowicz
    Academic press:
    Antioxidants & Redox Signaling (rok: 2014, tom: 20, strony: 1673-1676), Wydawca: Mary Ann Liebert, Inc
    Status:
    Published
    DOI:
    10.1089/ars.2013.5761 - link to the publication
  5. miR-146a deficiency does not aggravate muscular dystrophy in mdx mice.
    Authors:
    Bronisz-Budzyńska I, Chwalenia K, Mucha O, Podkalicka P, Karolina-Bukowska-Strakova, Józkowicz A, Łoboda A, Kozakowska M, Dulak J.
    Academic press:
    Skeletal Muscle (rok: 2019, tom: 9, strony: 22), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13395-019-0207-0. - link to the publication
  6. Adult stem cells: hopes and hypes of regenerative medicine.
    Authors:
    Dulak Jozef, Szade Krzysztof, Szade Agata, Nowak Witold, Józkowicz Alicja.
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 329-337), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2015_1023 - link to the publication
  7. Oksygenaza hemowa-1 – więcej niż cytoprotekcja/Heme oxygenase-1 - more than the cytoprotection
    Authors:
    Kozakowska Magdalena, Dulak Józef, Józkowicz Alicja.
    Academic press:
    Postępy Biochemii (rok: 2015, tom: 61, strony: 147-158), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  8. The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
    Authors:
    Krist Bart, Florczyk Urszula, Pietraszek-Gremplewicz Katarzyna, Józkowicz Alicja, Dulak Józef
    Academic press:
    International Journal of Endocrinology (rok: 2015, tom: 2015, strony: 2015:281756), Wydawca: Hindawi Press
    Status:
    Published
    DOI:
    10.1155/2015/281756. - link to the publication
  9. Lack of miR-378 attenuates muscular dystrophy in mdx mice
    Authors:
    Paulina Podkalicka, Olga Mucha, Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Anna Cetnarowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Maciej Cieśla, Maria Kulecka, Jerzy Ostrowski, Michał Mikuła, Alicja Józkowicz, Agnieszka Łoboda, Józef Dulak
    Academic press:
    Journal of Clinical Investigation Insight (tom: praca złożona, strony: ), Wydawca: American Society for Clinical Investigations
    Status:
    Submitted
    DOI:
    brak - link to the publication
  10. Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells.
    Authors:
    Stepniewski J, Pacholczak T, Skrzypczyk A, Ciesla M, Szade A, Szade K, Bidanel R, Langrzyk A, Grochowski R, Vandermeeren F, Kachamakova-Trojanowska N, Jez M, Drabik G, Nakanishi M, Jozkowicz A, Dulak J.
    Academic press:
    IUBMB Life. (rok: 2018, tom: 70, strony: 129-142), Wydawca: Wiley, International Union of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1002/iub.1711 - link to the publication
  11. Heme Oxygenase-1 influences satellite cells and progression of Duchenne muscular dystrophy in mice.
    Authors:
    Pietraszek-Gremplewicz K, Kozakowska M, Bronisz-Budzynska I, Ciesla M, Mucha O, Podkalicka P, Madej M, Glowniak U, Szade K, Stepniewski J, Jez M, Andrysiak K, Bukowska-Strakova K, Kaminska A, Kostera-Pruszczyk A, Jozkowicz A, Loboda A, Dulak J.
    Academic press:
    Antioxidants and Redox Sigaling (rok: 2018, tom: 29, strony: 128-148), Wydawca: Mary Ann Libert INc
    Status:
    Published
    DOI:
    10.1089/ars. - link to the publication
  12. Lack of Heme Oxygenase-1 Induces Inflammatory Reaction and Proliferation of Muscle Satellite Cells after Cardiotoxin-Induced Skeletal Muscle Injury.
    Authors:
    Kozakowska M, Pietraszek-Gremplewicz K, Ciesla M, Seczynska M, Bronisz-Budzynska I, Podkalicka P, Bukowska-Strakova K, Loboda A, Jozkowicz A, Dulak J.
    Academic press:
    American Journal of Pathology (rok: 2018, tom: 188, strony: 491-506), Wydawca: Elsevier, American Society for Investigative Pathology
    Status:
    Published
    DOI:
    10.017 - link to the publication
  13. Mięśniowe komórki progenitorowe - charakterystyka i funkcja.
    Authors:
    Kozakowska M, Dulak J, Józkowicz A.
    Academic press:
    Postępy Biologii Komórki (rok: 2015, tom: 42 (3), strony: 465-490), Wydawca: Polskie Towarzystwo Biologii Komórki
    Status:
    Published
    DOI:
    brak - link to the publication
  14. Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling.
    Authors:
    Gu W, Nowak WN, Xie Y, Le Bras A, Hu Y, Deng J, Issa Bhaloo S, Lu Y, Yuan H, Fidanis E, Saxena A, Kanno T, Mason AJ, Dulak J, Cai J, Xu Q.
    Academic press:
    Arterioscler Thromb Vasc Biol (rok: 2019, tom: Epub, strony: 2019 Jul 25), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/ATVBAHA.119.312732 - link to the publication
  15. Targeting angiogenesis in Duchenne muscular dystroophy
    Authors:
    Podkalicka P, Mucha O, Dulak J, Loboda A.
    Academic press:
    Cell Mol Life Sci. (rok: 2019, tom: 76, strony: 1507-1528), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03006-7 - link to the publication

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