Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification of potential therapeutic targets in melanoma stem-like cells

2012/06/M/NZ2/00109

Keywords:

melanoma cancer stem cells microenvironment transcriptom

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski z Oddziałem Stomatologicznym

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Czyż 

Number of co-investigators in the project: 6

Call: HARMONIA 3 - announced on 2012-06-15

Amount awarded: 444 600 PLN

Project start date (Y-m-d): 2013-03-25

Project end date (Y-m-d): 2016-01-24

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  1. Modulation of WNT/beta-catenin pathway in melanoma by biologically active components derived from plants
    Authors:
    Anna Gajos-Michniewicz & Malgorzata Czyz
    Academic press:
    Fitoterapia (rok: 2016, tom: 109, strony: 283-292), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fitote.2016.02.002 - link to the publication
  2. TGF-β signaling pathways in cancers
    Authors:
    Talar B, Czyż M.
    Academic press:
    Post Higieny i Med Dośw (rok: 2013, tom: 67, strony: 1008-1017), Wydawca: Państwowy Zakład Higieny
    Status:
    Published
    DOI:
    10.5604/17322693.1068073 - link to the publication
  3. Gene Expression Profiling Identifies Microphthalmia-Associated Transcription Factor (MITF) and Dickkopf-1 (DKK1) as Regulators of Microenvironment-Driven Alterations in Melanoma Phenotype
    Authors:
    Hartman ML, Talar B, Noman MZ, Gajos-Michniewicz A, Chouaib S, Czyz M
    Academic press:
    PLoS ONE (rok: 2014, tom: 9, strony: e95157), Wydawca: PLoS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0095157 - link to the publication
  4. Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-Mhigh melanoma cell populations
    Authors:
    Mariusz L. Hartman, Beata Talar, Malgorzata Sztiller-Sikorska, Dariusz Nejc, Malgorzata Czyz
    Academic press:
    ONCOTARGET (rok: 2016, tom: -, strony: -), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.7030 - link to the publication
  5. Pentoxifylline inhibits WNT signalling in β-cateninhigh patient-derived melanoma cell populations
    Authors:
    Beata Talar, Anna Gajos-Michniewicz, Marcin Talar Salem Chouaib and Malgorzata Czyz
    Academic press:
    PLoS One (rok: 2016, tom: 11, strony: e0158275), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0158275. - link to the publication
  6. Pro-Survival Role of MITF in Melanoma
    Authors:
    Hartman ML Czyz M
    Academic press:
    Journal of Investigative Dermatology (rok: 2015, tom: 135, strony: 352-358), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/jid.2014.319 - link to the publication

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