Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Experimental and clinical study of CD151-regulated activity of FGFR2 in breast cancer progression

2012/06/M/NZ3/00023

Keywords:

tertaspanin CD151 FGFR2 breast cancer

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Rafał Sądej 

Number of co-investigators in the project: 7

Call: HARMONIA 3 - announced on 2012-06-15

Amount awarded: 663 600 PLN

Project start date (Y-m-d): 2013-03-27

Project end date (Y-m-d): 2017-12-26

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  1. Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration
    Authors:
    Dominika Czaplinska, Lukasz Turczyk, Alicja Grudowska, Magdalena Mieszkowska, Andrea D. Lipinska, Andrzej C. Skladanowski, Anna J. Zaczek, Hanna M. Romanska, Rafal Sadej
    Academic press:
    BBA - Molecular Cell Research (rok: 2014, tom: 1843, strony: 2461–2470), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2014.06.022 - link to the publication
  2. FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells
    Authors:
    Turczyk L, Kitowska K, Mieszkowska M, Mieczkowski K, Czaplinska D, Piasecka D, Kordek R, Skladanowski AC, Potemski P, Romanska HM, Sadej R
    Academic press:
    Neoplasia (rok: 2017, tom: 19, strony: 791-804), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neo.2017.07.006 - link to the publication
  3. Lack of CD151/integrin alpha3beta1 complex is predictive of poor outcome in node–negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers
    Authors:
    Hanna M. Romanska, Piotr Potemski, Magdalena Krakowska, Magdalena Mieszkowska, Shalini Chaudhri, Radzisław Kordek, Robert Kubiak, Valerie Speirs, Andrew M. Hanby, Rafał Sadej, Fedor Berditchevski
    Academic press:
    British Journal of Cancer (rok: 2015, tom: 113, strony: 1350-1357), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/bjc.2015.344 - link to the publication
  4. Interactions between FGFR2 and RSK2-implications for breast cancer prognosis
    Authors:
    Czaplinska D, Mieczkowski K, Supernat A, Skladanowski AC, Kordek R, Biernat W, Zaczek AJ, Romanska HM, Sadej R.
    Academic press:
    Tumor Biology (rok: 2016, tom: 10, strony: 13721), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13277-016-5266-9 - link to the publication
  5. CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways
    Authors:
    Sadej R, Lu X, Turczyk L, Novitskaya V, Lopez-Clavijo AF, Kordek R, Potemski P, Wakelam MJO, Romanska H, Fedor Berditchevski.
    Academic press:
    Journal of Cell Science (rok: 2018, tom: 131, strony: pii: jcs220640), Wydawca: The company of biologists
    Status:
    Published
    DOI:
    10.1242/jcs.220640 - link to the publication
  6. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells.
    Authors:
    Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, Skladanowski AC, Zaczek AJ, Biernat W, Kordek R, Romanska HM, Sadej R.
    Academic press:
    Oncotarget (rok: 2016, tom: 7(52), strony: 86011-86025), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.13322 - link to the publication

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