Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Role of tumor necrosis factor (TNF) in regulation of pain reaction.

2012/05/B/NZ4/02385

Keywords:

TNF trigeminal neurons inflammatory reaction

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Bałkowiec-Iskra 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 500 266 PLN

Project start date (Y-m-d): 2013-02-05

Project end date (Y-m-d): 2019-02-04

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (7)
  1. TNF inhibitors – mechanisms of action, approved and off-label indications
    Authors:
    Grzegorz Cessak , Agnieszka Burda , Olga Kuzawińska, Krzysztof Lis, Marcin Wojnar, Dagmara Mirowska-Guzel, Ewa Bałkowiec-Iskra
    Academic press:
    Pharmacological Reports (rok: 2014, tom: 66, strony: 836-844), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep2014.05.004 - link to the publication
  2. Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment.
    Authors:
    Kuzawińska O, Lis K, Cessak G, Mirowska-Guzel D, Bałkowiec-Iskra E.
    Academic press:
    Neurologia i Neurochirurgia Polska (rok: 2016, tom: 50, strony: 463-467), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pjnns.2016.07.012 - link to the publication
  3. GENDER DIFFERENCES IN THE NEUROCHEMICAL RESPONSE OF TRIGEMINAL GANGLION NEURONS TO PERIPHERAL INFLAMMATION IN MICE.
    Authors:
    Olga Kuzawińska, Krzysztof Lis, Agnieszka Cudna, Ewa Bałkowiec-Iskra
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2014, tom: 74, strony: 227-232), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego
    Status:
    Published
  4. The role of the CGRP in the pathogenesis and treatment of migraine
    Authors:
    Olga Kuzawinska, Krzysztof Lis, Grzegorz Cessak, Ewa Bałkowiec-Iskra
    Academic press:
    Farmakoterapia w Psychiatrii i Neurologii (rok: 2015, tom: 31, strony: 127-140), Wydawca: Instytut Psychiatrii i Neurologii
    Status:
    Published
  5. Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund's Adjuvant by a TRPV1-dependent mechanism in mice
    Authors:
    Krzysztof Lis, Tomasz Grygorowicz, Agnieszka Cudna, David E. Szymkowski, Ewa Bałkowiec-Iskra
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 1380-1385), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.05.013 - link to the publication
  6. Tumor necrosis factor inhibitors – State of Knowledge
    Authors:
    Lis K., Kuzawińska O.,Bałkowiec-Iskra E.
    Academic press:
    Archives of Medical Science (rok: 2014, tom: 10, strony: 1175-1185), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/aoms.2014.47827. - link to the publication
  1. INHIBITION OF TNF REDUCES MECHANICAL OROFACIAL HYPERALGESIA INDUCED BY COMPLETE FREUND'S ADJUVANT BY A TRPV1-DEPENDENT MECHANISM IN MICE
    Authors:
    Krzysztof Lis, Agnieszka Cudna, Tomasz Grygorowicz, David E. Szymkowski, Ewa Bałkowiec-Iskra
    Conference:
    6th International Congress on Neuropathic Pain (rok: 2017, ), Wydawca: IASP
    Data:
    konferencja June 15-18
    Status:
    Published
  2. Gender differences in the neurochemical response of trigeminal ganglion neurons to peripheral inflammation in mice
    Authors:
    Kuzawinska O., Lis K., Cudna A., Bałkowiec-Iskra E
    Conference:
    Molecular Basis of Pathology and Therapy in neurological disorders (rok: 2014, ), Wydawca: Termedia
    Data:
    konferencja 20-21.11.2014
    Status:
    Published
  3. Peripheral inflammation affects function of trigeminal ganglion neurons.
    Authors:
    Olga Kuzawinska, Krzysztof Lis, Tomasz Grygorowicz, Agnieszka Cudna, Marta Dąbrowska, Dagmara Mirowska – Guzel, Ewa Bałkowiec-Iskra.
    Conference:
    3.XII International Congress of Polish Neuroscience Society, 6-8.09. 2015, Gdańsk, Polska. (rok: 2015, ), Wydawca: -
    Data:
    konferencja 6-8.09. 2015
    Status:
    Published
  4. Obwodowa reakcja zapalna wpływa na funkcje neuronów nerwu trójdzielnego u myszy
    Authors:
    Olga Kuzawińska, Krzysztof Lis, Tomasz Grygorowicz, Agnieszka Cudna, Dagmara Mirowska-Guzel, Ewa Bałkowiec-Iskra.
    Conference:
    VI Ogólnopolska Konferencja Postępu w Badaniach Biomedycznych (rok: 2015, ), Wydawca: -
    Data:
    konferencja 5-6 XII 2015
    Status:
    Published
  5. Peripheral inflammation affects trigeminal neurons function in mice.
    Authors:
    Olga Kuzawinska, Krzysztof Lis, Tomasz Grygorowicz, Agnieszka Cudna, Marta Dąbrowska, Dagmara Mirowska – Guzel, Ewa Bałkowiec-Iskra.
    Conference:
    2.XIX International Congress of The Polish Pharmacological Society, 17-19.09.2015 Swinoujście. (rok: 2015, ), Wydawca: Elservier
    Data:
    konferencja 17-19.09.2015
    Status:
    Published
  6. Selective inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund's Adjuvant by a TRPV1-dependent mechanism in mice.
    Authors:
    Krzysztof Lis1, Agnieszka Cudna, Tomasz Grygorowicz, David E. Szymkowski, Ewa Bałkowiec-Iskra.
    Conference:
    The XVI Congress of the Polish Society of Experimental and Clinical Immunology (rok: 2017, ), Wydawca: PZWL
    Data:
    konferencja 8-10 June 2017
    Status:
    Published
  7. Obwodowa reakcja zapalna indukowana CFA powoduje zmiany neurochemiczne w neuronach zwoju trójdzielnego
    Authors:
    Bałkowiec-Iskra E, Kuzawinska O, Cudna A, Lis K.
    Conference:
    Ból przewlekły, mechanizmy, terapia, Szkoła Zimowa IF PAN 2013 (rok: 2013, ), Wydawca: IF PAN
    Data:
    konferencja 19-22.02.2013
    Status:
    Published