Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The influence of some selected antiepileptic drugs in combination with arachinodyl-2-chlorethylamide, a selective cannabinoid CB1 receptor on neurogenesis in the mouse pilocarpine model of epilepsy

2012/05/B/NZ7/02459

Keywords:

ACEA antiepileptic drugs pilocarpine

Descriptors:

  • NZ4_10: Neuroimaging and computational neuroscience
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Wsi im. Witolda Chodźki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Andres-Mach 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 293 150 PLN

Project start date (Y-m-d): 2013-02-25

Project end date (Y-m-d): 2017-02-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikrotom SM2010 LEICA (40 000 PLN)
  2. Urządzenie sterujące z oprogramowaniem do ilościowej analizy komórek NeuN, GAP, oraz BrdU-pozytywnych (Zeiss lub Nikon) (7 000 PLN)
  3. Wytrząsarka orbitalna (Sigma-Sldrich) (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with antiepileptic drugs.
    Authors:
    Andres-Mach M, Haratym-Maj A, Zagaja M, Rola R, Maj M, Chrościńska-Krawczyk M, Luszczki JJ.
    Academic press:
    Brain Research (rok: 2015, tom: 1624, strony: 86-94), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.brainres.2015.07.028 - link to the publication
  2. Levetiracetam combined with ACEA, highly selective cannabinoid CB1 receptor agonist changes neurogenesis in mouse brain.
    Authors:
    Mirosław Zagaja; Agnieszka Haratym-Maj; Aleksandra Szewczyk; Radoslaw Rola; Maciej Maj; Jarogniew Łuszczki; Marta Andres- Mach
    Academic press:
    Neuroscience Letters (rok: 2019, tom: 23;696, strony: 79-86), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2018.12.016 - link to the publication
  3. Mechanisms of epileptogenesis and preclinical approach to antiepileptogenic therapies
    Authors:
    Krzysztof Łukawski, Marta Andres-Mach, Mirosław Czuczwar, Jarogniew J.Łuszczki, Krzysztof Kruszyński, Stanisław J.Czuczwar
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70, strony: 284-293), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.07.012 - link to the publication
  4. A Long-Term Treatment with Arachidonyl-2′-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy
    Authors:
    Marta Andres-Mach, Mirosław Zagaja, Agnieszka Haratym-Maj, Radosław Rola, Monika Dudra-Jastrzębska, Maciej Maj, Joanna Haratym, Jarogniew J. Łuszczki
    Academic press:
    International Journal of Molecular Science (rok: 2017, tom: 18, strony: 900), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms18050900 - link to the publication

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