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The effect of reductive activation of antitumour anthracycline antibiotics and their synthetic analogues on restoring cytostatic activity towards multidrug resistant cells originating from solid tumours

2012/05/B/NZ3/01985

Keywords

Descriptors

  • NZ3_1: Biologia komórki

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Szczeciński, Wydział Biologii

Voivodeship: zachodniopomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Jolanta Tarasiuk

Number of co-investigators in the project: 5

Call

OPUS 3 – announced on 2012-03-15

Amount awarded
297 000 PLN
Project start date
2013-02-13
Project end date
2016-02-12
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. System do bankowania komórek nowotworowych. Cost: 40 000 PLN
  2. Układ do pomiarów spektrofluorymetrycznych w nanoobjętościach. Cost: 10 000 PLN
  3. Zestaw pipet automatycznych.

Information in the final report

Publication in academic press/journals (1)

  1. DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells

    Authors:
    Wojciech Żwierełło, Agnieszka Maruszewska, Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Academic press:
    Pharmacological Reports (year: 2017, volume: 69, pages: 185-195), Publisher: Institute of Pharmacology of the Polish Academy of Sciences, Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2016.10.002 – link to the publication

Articles in post-conference publications (5)

  1. DNA damage induced by NADPH Cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells.

    Authors:
    Wojciech Żwierełło, Agnieszka Maruszewska, Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Conference:
    The 42nd Congress of the International Society of Oncology and Biomarkers (year: 2015, pages: 87-88), Publisher: Tumor Biology, International Society of Oncology and BioMarkers, Springer Science+Business Media B.V.
    Date:
    conference 3.10-7.10.
    Status:
    Published

  2. Effect of reductive activation of doxorubicin by NADPH cytochrome P450 reductase on cell cycle of sensitive and multidrug resistant MCF7 breast cancer cells

    Authors:
    Wojciech Żwierełło, Robert Nowak, Dorota Kostrzewa-Nowak, Agnieszka Maruszewska, Jolanta Tarasiuk
    Conference:
    XVIIIth Gliwice Scientific Meetings (year: 2014, pages: 159), Publisher: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
    Date:
    conference 21.11-22.11
    Status:
    Published
    DOI:
    link to the publication

  3. Effect of reductive activation of antitumour anthracycline drugs by NADPH cytochrome P450 reductase on their intracellular accumulation in sensitive LoVo and multidrug resistant LoVo/DX colon cancer cells

    Authors:
    Robert Nowak, Wojciech Żwierełło, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Conference:
    9th International Conference of Anticancer Research (year: 2014, pages: 6200-6201), Publisher: International Institute of Anticancer Research, Stanford University HighWire Press
    Date:
    conference 6.10-10.10
    Status:
    Published
    DOI:
    link to the publication

  4. DNA double-strand breaks induced by NADPH cytochrome P450 reductase-activated mitoxantrone in sensitive and multidrug resistant LoVo colon cancer cells.

    Authors:
    Wojciech Żwierełło, Agnieszka Maruszewska, Jolanta Tarasiuk
    Conference:
    XIXth Gliwice Scientific Meetings (year: 2015, pages: 163), Publisher: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
    Date:
    conference 20.11.-21.11.
    Status:
    Published
    DOI:
    link to the publication

  5. Effect of reductive activation of idarubicin by NADPH cytochrome P450 reductase on its intracellular accumulation in sensitive and multidrug resistant MCF7 breast cancer cells

    Authors:
    Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Conference:
    XVIIth Gliwice Scientific Meetings (year: 2013, pages: 100), Publisher: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
    Date:
    conference 15.11-16.11
    Status:
    Published
    DOI:
    link to the publication

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