Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of endocannabinoids in the regulation of the cardiovascular system, oxidative stres and heart metabolism in the models of primary and secondary hypertension

2012/05/B/NZ7/03102

Keywords:

endocannabinoids anandmide hypertension cardiovascular system oxidative stres heart metabolism

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Malinowska 

Number of co-investigators in the project: 10

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 842 550 PLN

Project start date (Y-m-d): 2013-01-25

Project end date (Y-m-d): 2016-07-24

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zbiornik z płaszczem grzejnym do buforu.
  2. Zestaw miografu drutowego (Multi Wire Myograph System - 620M, Danish Myo Technology-Ltd, Aarhus, Dania) (175 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (11)
  1. Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance.
    Authors:
    Malinowska B, Toczek M, Pędzińska-Betiuk A, Schlicker E.
    Academic press:
    British Journal of Pharmacology (rok: 2018, tom: 2018, strony: Epub ahead of print), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/bph.14168 - link to the publication
  2. The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on KCa2.3/KCa3.1-EDH-type relaxation in rat small mesenteric arteries.
    Authors:
    Kloza M, Baranowska-Kuczko M, Malinowska B, Karpińska O, Harasim-Symbor E, Kasacka I, Kozłowska H.
    Academic press:
    Vascular Pharmacology (rok: 2017, tom: 99, strony: 65-73), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.001 - link to the publication
  3. Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
    Authors:
    Toczek M, Baranowska-Kuczko M, Grzęda E, Pędzińska-Betiuk A, Weresa J, Malinowska B.
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68, strony: 363-369), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.004 - link to the publication
  4. Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats
    Authors:
    Toczek M., Schlicker E., Grzęda E., Malinowska B.
    Academic press:
    Life Sciences (rok: 2015, tom: 138, strony: 78-85), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2015.03.022 - link to the publication
  5. The endocannabinoid system affects myocardial glucose metabolism in the DOCA-Salt model of hypertension.
    Authors:
    Polak A, Harasim-Symbor E, Malinowska B, Kasacka I, Lewandowska A, Chabowski A.
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2018, tom: 46, strony: 727-739), Wydawca: S. Karger AG, Basel
    Status:
    Published
    DOI:
    10.1159/000488730 - link to the publication
  6. Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats.
    Authors:
    Pedzinska-Betiuk A, Weresa J, Toczek M, Baranowska-Kuczko M, Kasacka I, Harasim-Symbor E, Malinowska B.
    Academic press:
    British Journal of Pharmacology (rok: 2017, tom: 174, strony: 2114-2129), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/bph.13830 - link to the publication
  7. Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats.
    Authors:
    Baranowska-Kuczko M, Kozłowska H, Kloza M, Karpińska O, Toczek M, Harasim E, Kasacka I, Malinowska B.
    Academic press:
    Life Sciences (rok: 2016, tom: 151, strony: 288-299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2016.03.014 - link to the publication
  8. The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats.
    Authors:
    Polak A, Harasim-Symbor E, Malinowska B, Kasacka I, Pędzińska-Betiuk A, Weresa J, Chabowski A.
    Academic press:
    Life Sciences (rok: 2017, tom: 183, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2017.06.019 - link to the publication
  1. CB1 receptors in the paraventricular nucleus of the hypothalamus elicit central sympathoexcitation.
    Authors:
    Malinowska B., Grzęda E., Schlicker E.
    Conference:
    6th European Workshop on Cannabinoid Research (rok: 2013, ), Wydawca: British Pharmacological Society
    Data:
    konferencja 18-20. 04.
    Status:
    Published
    DOI:
    link to the publication
  2. Different physiological effects of chronic URB597 treatment in primary and secondary hypertension in rats
    Authors:
    Toczek M., Grzęda E., Pędzińska - Betiuk A., Weresa J., Kloza M., Baranowska - Kuczko M., Malinowska B.
    Conference:
    7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine (rok: 2015, ), Wydawca: International Association for Cannabinoid Medicines
    Data:
    konferencja 17-19. 09.
    Status:
    Published
    DOI:
    link to the publication
  3. Effects of endocannabinoid system activation on myocardial glucose metabolism in rat model of secondary hypertension.
    Authors:
    Polak A., Harasim-Symbor E., Malinowska B., Chabowski A.
    Conference:
    27th Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: Polskie Towarzystwo Fizjologiczne
    Data:
    konferencja 21-22. 09.
    Status:
    Published
  4. Cannabidiol-induced vasorelaxation in isolated human pulmonary and small mesenteric arteries of hypertensive rat - preliminary study
    Authors:
    Baranowska-Kuczko M., Kozłowska M., Kloza M., Karpińska O., Toczek M., Kozłowski M., Malinowska B.
    Conference:
    26th Annual Symposium of the International Cannabinoid Research Society (rok: 2016, ), Wydawca: International Cannabinoid Research Society
    Data:
    konferencja 26. 06. 2016 - 01. 07. 2016
    Status:
    Published
  5. Different effects of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiac performance and oxidative stress in normotensive and hypertensive rats
    Authors:
    Malinowska B., Pędzińska-Betiuk A., Weresa J., Biernacki M., Toczek M., Baranowska-Kuczko M., Skrzydlewska E.
    Conference:
    26th Annual Symposium of the International Cannabinoid Research Society (rok: 2016, ), Wydawca: International Cannabinoid Research Society
    Data:
    konferencja 26. 06.- 01. 07.
    Status:
    Published
  6. Effects of the chronic administration of FAAH inhibitor, URB597, on the cannabinoid-induced vasorelaxation in Doca-salt hypertensive rats
    Authors:
    Baranowska-Kuczko M, Kozłowska H, Kloza M, Karpińska O, Harasim E, Kasacka I, Malinowska B.
    Conference:
    7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine (rok: 2015, ), Wydawca: International Association for Cannabinoid Medicines
    Data:
    konferencja 17-19. 09.
    Status:
    Published
    DOI:
    link to the publication
  7. The pressor effect of cannabinoids in DOCA-salt hypertensive rats
    Authors:
    Grzęda E., Toczek M., Malinowska B.
    Conference:
    New Frontiers in Basic Cardiovascular Research 2014 (rok: 2014, ), Wydawca: Publishing & Printing House, Slovak Republic
    Data:
    konferencja 15 - 18.06.
    Status:
    Published
  8. Function of presynaptic inhibitory cannabinoid CB1 receptors on sympathetic nerves of spontaneously hypertensive rats
    Authors:
    Malinowska B., Toczek M., Kossakowsk R.i
    Conference:
    83rd Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) (rok: 2017, ), Wydawca: Springer
    Data:
    konferencja 06-09.03.
    Status:
    Published
    DOI:
    link to the publication
  9. Influence of FAAH inhibitor on the isoprenaline effects in isolated rat DOCA-salt hypertensive heart
    Authors:
    Pędzińska-Betiuk A., Skarżyńska J., Grzęda E., Malinowska B.
    Conference:
    New Frontiers in Basic Cardiovascular Research 2014 (rok: 2014, ), Wydawca: Publishing & Printing House, Slovak Republic
    Data:
    konferencja 15 - 18. 06.
    Status:
    Published
  10. Vascular effects of the chronic administration of FAAH inhibitor, URB597, in spontaneously hypertensive rats
    Authors:
    Baranowska-Kuczko M., Kozłowska H., Kloza M., Karpińska O., Kasacka I., Malinowska B.
    Conference:
    New Frontiers in Basic Cardiovascular Research, A France - new EU members symposium, Châtenay-Malabry, France (rok: 2016, ), Wydawca: University Paris-Sud
    Data:
    konferencja 03-06.07.
    Status:
    Published
  11. Wpływ inhibitora rozkładu anandamidu URB597 na wybrane parametry izolowanego serca i lewego przedsionka szczurów z nadciśnieniem DOCA-salt
    Authors:
    Weresa J., Pędzińska-Betiuk, Toczek M., Malinowska B.
    Conference:
    XIX Sympozjum Kardiologii Eksperymentalnej (rok: 2014, ), Wydawca: Polskie Towarzystwo Kardiologiczne oraz Komitet Nauk Fizjologicznych i Farmakologicznych PAN
    Data:
    konferencja 6 - 8. 11.
    Status:
    Published

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