Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identifcation of regulatory effects of bacteriophages with therapeutic potential on mammalian cell functions and immunity

2012/05/E/NZ6/03314

Keywords:

bacteriophage capsid proteins cell sygnaling mmunologia

Descriptors:

  • NZ3_1: Cell biology
  • NZ6_5: Virology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krystyna Dąbrowska 

Number of co-investigators in the project: 5

Call: SONATA BIS 1 - announced on 2012-03-15

Amount awarded: 1 445 000 PLN

Project start date (Y-m-d): 2013-02-14

Project end date (Y-m-d): 2018-02-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. wytrząsarka podręczna typu vortex.
  2. Spektrofotometr.
  3. komputer o wysokiej mocy obliczeniowej (2 szt.) (10 000 PLN)
  4. waga przenośna.
  5. wirówka laboratoryjna.
  6. zestaw do elektroforezy białkowej: forma podwójna z akcesoriami (2 szt.) (13 000 PLN)
  7. Inkubator do hodowli bakteryjnych z wytrząsaniem oraz pełną regulacją temperatury hodowli (grzenie i chłodzenie), do dużych objętości (do ok. 10 litrów). Zmienne platformy oraz napęd magnetyczny. (56 620 PLN)
  8. zamrażarka niskotemperaturowa skrzyniowa, -80 st C.
  9. pH-metr (3 140 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (9)
  • Book publications / chapters in book publications (1)
  1. Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System
    Authors:
    Jonas D. Van Belleghem, Krystyna Dąbrowska, Mario Vaneechoutte, Jeremy J. Barr
    Academic press:
    Viruses (rok: 2018, tom: 11(1), strony: E10), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v11010010 - link to the publication
  2. Real-Time qPCR as a Method for Detection of Antibody-Neutralized Phage Particles
    Authors:
    Kłopot Anna, Zakrzewska Adrina, Lecion Dorota, Majewska Joanna, Harhala Marek, Lahutta Karolina, Kaźmierczak Zuzanna, Łaczmański Łukasz, Kłak Marlena, Dąbrowska Krystyna
    Academic press:
    Frontiers in Microbiology (rok: 2017, tom: 8, strony: 2170), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2017.02170 - link to the publication
  3. Capsid protein Hoc helps bacteriophage T4 to escape clearance from blood by the complement system
    Authors:
    Paulina Miernikiewicz, Joanna Majewska, Zuzanna Kaźmierczak, Anna Kłopot, Dorota Lecion, Marek Harhala, Barbara Owczarek, Ewa Jończyk, Andrzej Górski, Krystyna Dąbrowska
    Academic press:
    European Journal of Immunology (rok: 2019, ), Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Correlations of host genetics and gut microbiome composition
    Authors:
    Dąbrowska K, Witkiewicz W
    Academic press:
    Frontiers in Microbiology (rok: 2016, tom: 7, strony: 1357), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01357 - link to the publication
  5. Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review
    Authors:
    Krystyna Dabrowska
    Academic press:
    Medicinal Research Reviews (rok: 2019, tom: 39(5), strony: 2000-2025), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/med.21572 - link to the publication
  6. Natural and induced antibodies against phages in humans: induction kinetics and immunogenicity for structural proteins of PB1-related phages
    Authors:
    Katarzyna Hodyra-Stefaniak, Zuzanna Kaźmierczak, Joanna Majewska, Sanna Sillankorva, Paulina Miernikiewicz, Ryszard Międzybrodzki, Andrzej Górsk, Joana Azeredo, Rob Lavigne, Dorota Lecion, Sylwia Nowak, Marek Harhala, Patryk Waśko, Barbara Owczarek, Krystyna Dąbrowska
    Academic press:
    mBIO (rok: 2019, ), Wydawca: American Society for Microbiology
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. Mammalian Host-Versus-Phage immune response determines phage fate in vivo
    Authors:
    Hodyra-Stefaniak K., Miernikiewicz P., Drapała J., Drab M., Jończyk-Matysiak E., Lecion D, Kaźmierczak Z., Beta W., Majewska J., Harhala M., Bubak B., Kłopot A., Górski A., Dąbrowska K.
    Academic press:
    Scientific Reports (rok: 2015, tom: 5, strony: 14802), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep14802 - link to the publication
  8. Oral application of T4 phage induces weak antibody production in the gut and in the blood
    Authors:
    Majewska J., Beta W., Lecion D., Hodyra-Stefaniak K., Kłopot A., Kaźmierczak Z., Miernikiewicz P., Piotrowicz A., Ciekot J., Owczarek B., Kopciuch A., Wojtyna K., Harhala M., Mąkosa M., Dąbrowska K.
    Academic press:
    Viruses (rok: 2015, tom: 7, strony: 4783-4799), Wydawca: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/v7082845 - link to the publication
  9. Endocytosis in Cellular Uptake of Drug Delivery Vectors: Molecular Aspects in Drug Development
    Authors:
    Zuzanna Kaźmierczak, Kamila Szostak, Magdalena Przybyło, Marek Langner, Wojciech Witkiewicz, Krystyna Dąbrowska
    Academic press:
    Journal of Drug Targeting (tom: JDT-2018-0076, strony: ), Wydawca: Taylor & Francis
    Status:
    Submitted
    DOI:
    brak - link to the publication
  10. Delivering phage therapy per os: benefits and barriers
    Authors:
    Zelasko S, Gorski A, Dabrowska K
    Academic press:
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (rok: 2017, tom: 15, strony: 167-179), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.2017.1265447 - link to the publication
  11. Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool
    Authors:
    Kaźmierczak Z, Górski A, Dąbrowska K
    Academic press:
    Viruses (rok: 2014, tom: 6, strony: 2551-2570), Wydawca: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/v6072551 - link to the publication
  12. Immunogenicity studies of proteins forming the T4 phage head surface
    Authors:
    Dąbrowska K, Miernikiewicz P, Piotrowicz A, Hodyra K, Owczarek B, Lecion D, Kaźmierczak Z, Letarov A, Górski A
    Academic press:
    Journal of Virology (rok: 2014, tom: 88, strony: 12551-12557), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.02043-14 - link to the publication
  13. Induction of Phage-Specific Antibodies by Two Therapeutic Staphylococcal Bacteriophages Administered per os
    Authors:
    Joanna Majewska, Zuzanna Kaźmierczak, Karolina Lahutta, Dorota Lecion, Aleksander Szymczak, Paulina Miernikiewicz, Jarosław Drapała, Marek Harhala, Karolina Marek-Bukowiec, Natalia Jędruchniewicz, Barbara Owczarek, Andrzej Górski, Krystyna Dąbrowska
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 2607), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02607 - link to the publication
  14. Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies
    Authors:
    Krystyna Dabrowska, Stephen Abedon
    Academic press:
    Microbiology and Molecular Biology Reviews (rok: 2019, tom: 83(4), strony: e00012-19), Wydawca: American Society for Microbiology (ASM)
    Status:
    Published
    DOI:
    10.1128/MMBR.00012-19 - link to the publication
  1. Immunological reactions to bacteriophage applied in vivo
    Authors:
    Dąbrowska K.
    Conference:
    Bacteriophages: Theoretical and Practical Aspects of Their Application in Medicine, Veterinary and Food, Third International Scientific Conference, To the 100th Anniversary of the Discovery of Bacteriophages (rok: 2016, ), Wydawca: Medical Marketing Agency, Moscow
    Data:
    konferencja 13-15.10.2016
    Status:
    Published
  2. Antibody production in mice challenged with anti-staphylococcal bacteriophages and studies of potential structural phage proteins
    Authors:
    Kaźmierczak Z., Majewska J., KataHodyra-Stefaniak K., Beta W., Kłopot A., Harhala M., Lisowska M., Lecion D., Owczarek B., Kopciuch A., Dziuban A., Górski A., Dąbrowska K.
    Conference:
    100 Years of Phage, 21st Biennial Evergreen International Phage Meeting (rok: 2015, ), Wydawca: Evergreen State Colleague, Olympia, USA
    Data:
    konferencja 2-7.08.2015
    Status:
    Published
  3. Induction of antibodies by bacteriophages
    Authors:
    Dąbrowska K., Miernikiewicz P., Hodyra-Stefaniak K., Majewska J., Kaźmierczak Z., Harhala M., Lecion D., Kłopot A., Beta W., Wojtyna K., Górski A.
    Conference:
    6th Annual Conference Phages 2016 Bacteriophage in Medicine, Food and Biotechnology (rok: 2016, ), Wydawca: St Hilda's College, Oxford
    Data:
    konferencja 07 – 08.09.2016
    Status:
    Published
  4. Oral application of T4 phage induces weak antibody production in the gut and in the blood
    Authors:
    Majewska J., Beta W., Lecion D., Hodyra-Stefaniak K., Kłopot A., Kaźmierczak Z., Miernikiewicz P., Piotrowicz A., Ciekot J., Owczarek B., Kopciuch A., Wojtyna K., Harhala M., Mąkosa M., Dąbrowska K.
    Conference:
    100 Years of Phage, 21st Biennial Evergreen International Phage Meeting (rok: 2015, ), Wydawca: Evergreen State Colleague, Olympia, USA
    Data:
    konferencja 2-7.08.2015
    Status:
    Published
  5. Comparison of purification methods for Pseudomonas aeruginosa and Escherichia coli bacteriophages
    Authors:
    Miernikiewicz P, Hodyra K, Lecion D, Piotrowicz A, Owczarek B, Majewska J, Górski A, Dąbrowska K
    Conference:
    EMBO Conferences, Viruses of Microbes III: Stucture and Function - from Molecules to Communities (rok: 2014, ), Wydawca: Eidgenossische Technishe Hochschule, Zurich
    Data:
    konferencja 14-18.07.2014
    Status:
    Published
  6. Anti-staphylococcal bacteriophages antibody production in a murine model
    Authors:
    Kaźmierczak Z, Majewska J, Harhala M, Piotrowicz A, Miernikiewicz P, Hodyra K, Beta W, Lisowska M, Owczarek B, Kopciuch A, Lecion D, Górski A, Dąbrowska K
    Conference:
    EMBO Conferences, Viruses of Microbes III: Stucture and Function - from Molecules to Communities (rok: 2014, ), Wydawca: Eidgenossische Technishe Hochschule, Zurich
    Data:
    konferencja 14-18.07.2014
    Status:
    Published
  7. Deletion of selected T4 phage head proteins affects phage resistance to acidic pH in vitro and in vivo
    Authors:
    Majewska J., Beta W., Kaźmierczak Z., Hodyra- Stefaniak K., Lecion D., Kłopot A., Owczarek B., Kopciuch A., Wojtyna K., Mąkosa M., Letarov A., Górski A., Dąbrowska K.
    Conference:
    100 Years of Phage, 21st Biennial Evergreen International Phage Meeting (rok: 2015, ), Wydawca: Evergreen State Colleague, Olympia, USA
    Data:
    konferencja 2-7.08.2015
    Status:
    Published
  8. Bacteriophage neutralization in vivo involves the complement system
    Authors:
    Dabrowska K, Kłopot A, Lecion D, Hodyra-Stefaniak K, Kaźmierczak Z, Kęska W, Majewska J, Harhala M, Waśko P, Miernikiewicz P, Gorski A
    Conference:
    EMBO Conferences: Viruses of Microbes 2016 (rok: 2016, ), Wydawca: EMBO
    Data:
    konferencja 18-22.07.2016
    Status:
    Published
  9. Comparison of innate and adaptive immunity impact on bacteriophage circulation and viability in the mammalian system
    Authors:
    Dabrowska K, Miernikiewicz P, Hodyra K, Drapała J, Drab M, Jończyk E, Lecion D, Kaźmierczak Z, Piotrowicz A, Gorski A
    Conference:
    EMBO Conferences, Viruses of Microbes III: Stucture and Function - from Molecules to Communities (rok: 2014, ), Wydawca: Eidgenossische Technishe Hochschule, Zurich
    Data:
    konferencja 14-18.07.2014
    Status:
    Published
  1. Interaction of Bacteriophages with Mammalian Cells
    Authors:
    Kaźmierczak Z., Dąbrowska K
    Book:
    Phage therapy: from lab to market (rok: 2018, tom: 1693, strony: 113-122), Wydawca: Springer
    Status:
    Published

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