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Identifcation of regulatory effects of bacteriophages with therapeutic potential on mammalian cell functions and immunity

2012/05/E/NZ6/03314

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ6_5: Wirusologia

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Krystyna Dąbrowska

Number of co-investigators in the project: 5

Call

SONATA BIS 1 – announced on 2012-03-15

Amount awarded
1 445 000 PLN
Project start date
2013-02-14
Project end date
2018-02-13
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Inkubator do hodowli bakteryjnych z wytrząsaniem oraz pełną regulacją temperatury hodowli (grzenie i chłodzenie), do dużych objętości (do ok. 10 litrów). Zmienne platformy oraz napęd magnetyczny.. Cost: 56 620 PLN
  2. Spektrofotometr.
  3. komputer o wysokiej mocy obliczeniowej (2 pcs). Cost: 10 000 PLN
  4. pH-metr. Cost: 3 140 PLN
  5. waga przenośna.
  6. wirówka laboratoryjna.
  7. wytrząsarka podręczna typu vortex.
  8. zamrażarka niskotemperaturowa skrzyniowa, -80 st C.
  9. zestaw do elektroforezy białkowej: forma podwójna z akcesoriami (2 pcs). Cost: 13 000 PLN

Information in the final report

Publication in academic press/journals (11)

  1. Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System

    Authors:
    Jonas D. Van Belleghem, Krystyna Dąbrowska, Mario Vaneechoutte, Jeremy J. Barr
    Academic press:
    Viruses (year: 2018, volume: 11(1), pages: E10), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/v11010010 – link to the publication

  2. Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool

    Authors:
    Kaźmierczak Z, Górski A, Dąbrowska K
    Academic press:
    Viruses (year: 2014, volume: 6, pages: 2551-2570), Publisher: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/v6072551 – link to the publication

  3. Mammalian Host-Versus-Phage immune response determines phage fate in vivo

    Authors:
    Hodyra-Stefaniak K., Miernikiewicz P., Drapała J., Drab M., Jończyk-Matysiak E., Lecion D, Kaźmierczak Z., Beta W., Majewska J., Harhala M., Bubak B., Kłopot A., Górski A., Dąbrowska K.
    Academic press:
    Scientific Reports (year: 2015, volume: 5, pages: 14802), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep14802 – link to the publication

  4. Induction of Phage-Specific Antibodies by Two Therapeutic Staphylococcal Bacteriophages Administered per os

    Authors:
    Joanna Majewska, Zuzanna Kaźmierczak, Karolina Lahutta, Dorota Lecion, Aleksander Szymczak, Paulina Miernikiewicz, Jarosław Drapała, Marek Harhala, Karolina Marek-Bukowiec, Natalia Jędruchniewicz, Barbara Owczarek, Andrzej Górski, Krystyna Dąbrowska
    Academic press:
    Frontiers in Immunology (year: 2019, volume: 10, pages: 2607), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02607 – link to the publication

  5. Delivering phage therapy per os: benefits and barriers

    Authors:
    Zelasko S, Gorski A, Dabrowska K
    Academic press:
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (year: 2017, volume: 15, pages: 167-179), Publisher: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/14787210.2017.1265447 – link to the publication

  6. Correlations of host genetics and gut microbiome composition

    Authors:
    Dąbrowska K, Witkiewicz W
    Academic press:
    Frontiers in Microbiology (year: 2016, volume: 7, pages: 1357), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01357 – link to the publication

  7. Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies

    Authors:
    Krystyna Dabrowska, Stephen Abedon
    Academic press:
    Microbiology and Molecular Biology Reviews (year: 2019, volume: 83(4), pages: e00012-19), Publisher: American Society for Microbiology (ASM)
    Status:
    Published
    DOI:
    10.1128/MMBR.00012-19 – link to the publication

  8. Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

    Authors:
    Krystyna Dabrowska
    Academic press:
    Medicinal Research Reviews (year: 2019, volume: 39(5), pages: 2000-2025), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/med.21572 – link to the publication

  9. Immunogenicity studies of proteins forming the T4 phage head surface

    Authors:
    Dąbrowska K, Miernikiewicz P, Piotrowicz A, Hodyra K, Owczarek B, Lecion D, Kaźmierczak Z, Letarov A, Górski A
    Academic press:
    Journal of Virology (year: 2014, volume: 88, pages: 12551-12557), Publisher: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.02043-14 – link to the publication

  10. Real-Time qPCR as a Method for Detection of Antibody-Neutralized Phage Particles

    Authors:
    Kłopot Anna, Zakrzewska Adrina, Lecion Dorota, Majewska Joanna, Harhala Marek, Lahutta Karolina, Kaźmierczak Zuzanna, Łaczmański Łukasz, Kłak Marlena, Dąbrowska Krystyna
    Academic press:
    Frontiers in Microbiology (year: 2017, volume: 8, pages: 2170), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2017.02170 – link to the publication

  11. Oral application of T4 phage induces weak antibody production in the gut and in the blood

    Authors:
    Majewska J., Beta W., Lecion D., Hodyra-Stefaniak K., Kłopot A., Kaźmierczak Z., Miernikiewicz P., Piotrowicz A., Ciekot J., Owczarek B., Kopciuch A., Wojtyna K., Harhala M., Mąkosa M., Dąbrowska K.
    Academic press:
    Viruses (year: 2015, volume: 7, pages: 4783-4799), Publisher: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/v7082845 – link to the publication

Articles in post-conference publications (9)

  1. Bacteriophage neutralization in vivo involves the complement system

    Authors:
    Dabrowska K, Kłopot A, Lecion D, Hodyra-Stefaniak K, Kaźmierczak Z, Kęska W, Majewska J, Harhala M, Waśko P, Miernikiewicz P, Gorski A
    Conference:
    EMBO Conferences: Viruses of Microbes 2016 (year: 2016, pages: 80), Publisher: EMBO
    Date:
    conference 18-22.07.2016
    Status:
    Published

  2. Antibody production in mice challenged with anti-staphylococcal bacteriophages and studies of potential structural phage proteins

    Authors:
    Kaźmierczak Z., Majewska J., KataHodyra-Stefaniak K., Beta W., Kłopot A., Harhala M., Lisowska M., Lecion D., Owczarek B., Kopciuch A., Dziuban A., Górski A., Dąbrowska K.
    Conference:
    100 Years of Phage, 21st Biennial Evergreen International Phage Meeting (year: 2015, pages: 134), Publisher: Evergreen State Colleague, Olympia, USA
    Date:
    conference 2-7.08.2015
    Status:
    Published

  3. Deletion of selected T4 phage head proteins affects phage resistance to acidic pH in vitro and in vivo

    Authors:
    Majewska J., Beta W., Kaźmierczak Z., Hodyra- Stefaniak K., Lecion D., Kłopot A., Owczarek B., Kopciuch A., Wojtyna K., Mąkosa M., Letarov A., Górski A., Dąbrowska K.
    Conference:
    100 Years of Phage, 21st Biennial Evergreen International Phage Meeting (year: 2015, pages: 135), Publisher: Evergreen State Colleague, Olympia, USA
    Date:
    conference 2-7.08.2015
    Status:
    Published

  4. Anti-staphylococcal bacteriophages antibody production in a murine model

    Authors:
    Kaźmierczak Z, Majewska J, Harhala M, Piotrowicz A, Miernikiewicz P, Hodyra K, Beta W, Lisowska M, Owczarek B, Kopciuch A, Lecion D, Górski A, Dąbrowska K
    Conference:
    EMBO Conferences, Viruses of Microbes III: Stucture and Function - from Molecules to Communities (year: 2014, pages: 208), Publisher: Eidgenossische Technishe Hochschule, Zurich
    Date:
    conference 14-18.07.2014
    Status:
    Published

  5. Oral application of T4 phage induces weak antibody production in the gut and in the blood

    Authors:
    Majewska J., Beta W., Lecion D., Hodyra-Stefaniak K., Kłopot A., Kaźmierczak Z., Miernikiewicz P., Piotrowicz A., Ciekot J., Owczarek B., Kopciuch A., Wojtyna K., Harhala M., Mąkosa M., Dąbrowska K.
    Conference:
    100 Years of Phage, 21st Biennial Evergreen International Phage Meeting (year: 2015, pages: 51), Publisher: Evergreen State Colleague, Olympia, USA
    Date:
    conference 2-7.08.2015
    Status:
    Published

  6. Immunological reactions to bacteriophage applied in vivo

    Authors:
    Dąbrowska K.
    Conference:
    Bacteriophages: Theoretical and Practical Aspects of Their Application in Medicine, Veterinary and Food, Third International Scientific Conference, To the 100th Anniversary of the Discovery of Bacteriophages (year: 2016, pages: 15), Publisher: Medical Marketing Agency, Moscow
    Date:
    conference 13-15.10.2016
    Status:
    Published

  7. Induction of antibodies by bacteriophages

    Authors:
    Dąbrowska K., Miernikiewicz P., Hodyra-Stefaniak K., Majewska J., Kaźmierczak Z., Harhala M., Lecion D., Kłopot A., Beta W., Wojtyna K., Górski A.
    Conference:
    6th Annual Conference Phages 2016 Bacteriophage in Medicine, Food and Biotechnology (year: 2016, pages: 20), Publisher: St Hilda's College, Oxford
    Date:
    conference 07 – 08.09.2016
    Status:
    Published

  8. Comparison of purification methods for Pseudomonas aeruginosa and Escherichia coli bacteriophages

    Authors:
    Miernikiewicz P, Hodyra K, Lecion D, Piotrowicz A, Owczarek B, Majewska J, Górski A, Dąbrowska K
    Conference:
    EMBO Conferences, Viruses of Microbes III: Stucture and Function - from Molecules to Communities (year: 2014, pages: 187), Publisher: Eidgenossische Technishe Hochschule, Zurich
    Date:
    conference 14-18.07.2014
    Status:
    Published

  9. Comparison of innate and adaptive immunity impact on bacteriophage circulation and viability in the mammalian system

    Authors:
    Dabrowska K, Miernikiewicz P, Hodyra K, Drapała J, Drab M, Jończyk E, Lecion D, Kaźmierczak Z, Piotrowicz A, Gorski A
    Conference:
    EMBO Conferences, Viruses of Microbes III: Stucture and Function - from Molecules to Communities (year: 2014, pages: 49, section: invited speakers), Publisher: Eidgenossische Technishe Hochschule, Zurich
    Date:
    conference 14-18.07.2014
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Interaction of Bacteriophages with Mammalian Cells

    Authors:
    Kaźmierczak Z., Dąbrowska K
    Book:
    Phage therapy: from lab to market (year: 2018, volume: 1693, pages: 113-122), Publisher: Springer
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski