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Information of the project and the call

Keywords

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Biological mechanism of resting state raft formation and their participation in the regulation of certain cellular functions. Role of (palmitoylated) protein MPP1

2012/05/B/NZ1/01638

Keywords:

Membrane rafts Protein palmitoylation MPP1 Signal transduction Biological membranes

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksander Sikorski 

Number of co-investigators in the project: 4

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 650 600 PLN

Project start date (Y-m-d): 2013-02-22

Project end date (Y-m-d): 2016-04-21

Project duration:: 38 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówki stołowe z chłodzeniem (2 sztuki), 38000 zł zakup w 10 miesiącu od rozpoczęcia projektu. Cena zawiera podatek VAT (38 000 PLN)
  2. Zestaw do elektroforezy i elektroblotting (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (1)
  1. Protein palmitoylation: Palmitoyltransferases and their specificity
    Authors:
    Sabina Tabaczar, Aleksander Czogalla, Joanna Podkalicka, Agnieszka Biernatowska and Aleksander F Sikorski
    Academic press:
    Experimental Biology and Medicine (rok: 2017, tom: 242, strony: 1150-1157), Wydawca: SAGE/SEBM
    Status:
    Published
    DOI:
    10.1177/1535370217707732 - link to the publication
  2. MPP1 as a Factor Regulating Phase Separation in Giant Plasma Membrane-Derived Vesicles
    Authors:
    Joanna Podkalicka1,4, Agnieszka Biernatowska1, Michał Majkowski1, Michał Grzybek2,3 and Aleksander F. Sikorski1
    Academic press:
    Biophysical Journal (rok: 2015, tom: 108(9), strony: 2201-11), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.bpj.2015.03.017. - link to the publication
  3. Membrane rafts as a novel target in cancer therapy
    Authors:
    Anita Hryniewicz-Jankowska, Katarzyna Augoff, Agnieszka Biernatowska, Joanna Podkalicka, Aleksander F. Sikorski
    Academic press:
    Biochimica et Biophysica Acta - reviews on Cancer (rok: 2014, tom: 1845, strony: 155-165), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbcan.2014.01.006 - link to the publication
  4. The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras
    Authors:
    Joanna Podkalicka1, Agnieszka Biernatowska1, Paulina Olszewska, Sabina Tabaczar, Aleksander F. Sikorski*
    Academic press:
    Oncotarget , Wydawca: Imp. Journals
    Status:
    Accepted for publication
    DOI:
    Brak - link to the publication
  5. Cholesterol interaction with the MAGUK protein family member, MPP1, via CRAC and CRAC-like motifs: An in silico docking analysis
    Authors:
    Marcin A. Listowski1, Jacek Leluk2, Sebastian Kraszewski, Aleksander F. Sikorski1,2,*
    Academic press:
    PLOS ONE (rok: 2015, tom: 10(7):, strony: e0133141), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0133141. - link to the publication
  6. MPP1 directly interacts with flotillins in erythrocyte membranes – possible mechanism of resting-state raft formation
    Authors:
    Agnieszka Biernatowska1*, Joanna Podkalicka1*, Katarzyna Augoff*2, Sabina Tabaczar1, Weronika Gajdzik1, Aleksander Czogalla1, Aleksander F. Sikorski
    Academic press:
    Biochimica et Biophysica Acta (rok: 2017, tom: 1859, strony: 2203-2212), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2017.08.021 - link to the publication
  7. MPP1 interacts with DOPC/SM/cholesterol in an artificial membrane system using Langmuir-Blodgett monolayer
    Authors:
    Mohamed Elderdfi, Jolanta Zegarlińska, Walis Jones and Aleksander F. Sikorski
    Academic press:
    Gen. Physiol. Biophys. (rok: 2017, tom: 36, strony: 443–454), Wydawca: AEPress
    Status:
    Published
    DOI:
    10.4149/gpb_2017002 - link to the publication
  1. Membrane Palmitoylated Protein 1 (MPP1) as a tuning factor regulating functional microdomains formation in the plasma membrane,
    Authors:
    Podkalicka, J., Biernatowska, A., Majkowski, M., Sikorski A.F.
    Conference:
    1st Congress BIO 2014 of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics, Warszawa 9-12.IX.2014, (rok: 2014, ), Wydawca: Acta Biochimica Polonica Vol. 61, Suppl. 1/2014
    Data:
    konferencja 9-12.IX.2014,
    Status:
    Published
  2. MPP1 as a major organizer of membrane domains in erythroid cells
    Authors:
    Sikorski A.F.
    Conference:
    IUMB 10th International Conference on Biochemical Roles of Eucaryotic Cell Surface Molecules (rok: 2014, ), Wydawca: Saha Institute for Nuclear Physics
    Data:
    konferencja 20-24.01
    Status:
    Published
  3. MPP1 dependent lipid-raft assembly is required for H-Ras activation during insulin receptor signaling.
    Authors:
    Podkalicka, J. Biernatowska, A., Majkowski M., Sikorski A.F.
    Conference:
    10th EBSA European Biophysics Congress, 18-22 July 2015, Dresden, Germany: (rok: 2015, ), Wydawca: Eur. Biophys. j. Vol. 44, Suppl. 1/2015, S43-S248; P-283, str.116
    Data:
    konferencja 18-22 July
    Status:
    Published
  1. Membrane rafts in the erythrocyte membrane: a novel role of MPP1p55.
    Authors:
    Sikorski AF, Podkalicka J, Jones W, Biernatowska A.
    Book:
    Adv Exp Med Biol. (rok: 2015, tom: 842, strony: 61-78), Wydawca: Springer
    Status:
    Published

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