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Information on the principal investigator and host institution

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The role of P2X7 receptor in pathomechanism of experimental autoimmune encephalomyelitis (EAE) in rats

2012/05/N/NZ4/02191

Keywords:

Multiple sclerosis EAE neurodegeneration inflammation P2X7R BBG

Descriptors:

  • NZ4_5: Anatomical pathology
  • NZ4_9: Systems neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Tomasz Grygorowicz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 148 980 PLN

Project start date (Y-m-d): 2013-02-19

Project end date (Y-m-d): 2016-08-18

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. Early P2X7R-related astrogliosis in autoimmune encephalomyelitis
    Authors:
    Tomasz Grygorowicz, MarlenaWełniak-Kamińska, Lidia Strużyńska
    Academic press:
    Molecular and Cellular Neuroscience (rok: 2016, tom: 74, strony: 45300), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.mcn.2016.02.003 - link to the publication
  2. Administration of an antagonist of P2X7 receptor to EAE rats prevents a decrease of expression of claudin-5 in cerebral capillaries.
    Authors:
    Tomasz Grygorowicz; Beata Dąbrowska-Bouta; Lidia Strużyńska
    Academic press:
    Purinergic Signalling (rok: 2018, tom: 45512, strony: [Epub ahead of print]), Wydawca: Springer Netherlands
    Status:
    Published
    DOI:
    10.1007/s11302-018-9620-9 - link to the publication
  1. Purinergic receptor P2X7 expression in brain microvessels and its role in blood-brain barrier tightness during the course of EAE
    Authors:
    Grygorowicz T., Rafałowska J., Lenkiewicz A., Strużyńska L.
    Conference:
    8th International Symposium on Neuroprotection and Neurorepair (rok: 2014, ), Wydawca: brak
    Data:
    konferencja 9-12.04.2014
    Status:
    Published
  2. The role of P2X7R in activation of glial cells during the early phase of experimental autoimmune encephalomyelitis
    Authors:
    Tomasz Grygorowicz, Marlena Wełniak-Kamińska, Aleksandra Lenkiewicz, Lidia Strużyńska
    Conference:
    12th Internatinal congress Polish Neuroscience Society (rok: 2015, ), Wydawca: Polish Neuroscience Society - PTBUN, Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8. 09. 2015
    Status:
    Published
    DOI:
    link to the publication
  3. Possible role of microvessel - located P2X7R in BBB function during the course of EAE
    Authors:
    Grygorowicz T., Rafałowska J., Lenkiewicz A., Chrzanowska H., Wojda R., Szopiński R., Strużyńska L.
    Conference:
    11th Internatinal congress Polish Neuroscience Society (rok: 2013, ), Wydawca: Polish Neuroscience Society - PTBUN, Nencki Institute of Experimental Biology
    Data:
    konferencja 15-17.09.2013
    Status:
    Published
    DOI:
    link to the publication
  4. Influence of P2X7R antagonist on glia activation in the early time point of EAE
    Authors:
    Grygorowicz T., Lenart J., Lenkiewicz A., Strużyńska L.
    Conference:
    The 12th International Symposium: Molecular basis of pathology and therapy in neurological disorders (rok: 2014, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 20-21.11.2014
    Status:
    Published
    DOI:
    link to the publication
  5. The effect of P2X7R antagonist on the inflammatory process during experimental autoimmune encephalomyelitis
    Authors:
    Tomasz Grygorowicz, Monika A. Grygorowicz, Jacek Lenart, Marlena Wełniak-Kamińska, Aleksandra Lenkiewicz, Lidia Strużyńska
    Conference:
    FENS Featured Regional Meeting 2015 (rok: 2015, ), Wydawca: brak
    Data:
    konferencja 7-10. 10. 2015
    Status:
    Published
    DOI:
    link to the publication

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