Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Finding a role of LAT adaptor in development of T cell acute lymphoblastic leukemia (T-ALL)

2012/05/B/NZ5/01339

Keywords:

T-ALL LAT LCKY505F CD3ε gene expression profiling signaling pathways

Descriptors:

  • NZ5_4: Pathogenesis of animal diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Arkadiusz Miążek 

Number of co-investigators in the project: 2

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 316 848 PLN

Project start date (Y-m-d): 2013-01-24

Project end date (Y-m-d): 2016-01-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mała wytrząsarka orbitalna firmy IKA, model MS 3 digital, do płytek titracyjnych (nr kat. IKA3319000) (3 700 PLN)
  2. Mikrowirówka Sigma, model 1-14K z chłodzeniem, zakupiona z rotorem na 24 probówek typu eppendorf 1.5 ml-2.2 ml oraz rotorem na paski probówek 8x0,2ml (nr katalogowy całego zestawu 10020) (19 550 PLN)
  3. Zestaw do elektroforezy białek Mini-Protean Tetra (nr kat. #165-8000) zakupiony razem z kompatybilnym zasilaczem PowerPac HC (nr kat. # 164-5052) firmy Bio-Rad (9 300 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Non-T cell activation linker (NTAL) proteolytic cleavage as a terminator of activatory intracellular signals
    Authors:
    Mikel M. Arbulo-Echevarria,* Juan Pedro Muñoz-Miranda,* Andr´es Caballero-Garc´ıa,* Jos´e L. Poveda-D´ıaz,* Cecilia Fern´andez-Ponce,* Mª Carmen Dur´an-Ruiz,† Arkadiusz Miazek,‡ Francisco Garc´ıa-C´ozar,* and Enrique Aguado*,1
    Academic press:
    Journal of Leukocyte Biology (rok: 2016, tom: 100, strony: 000-000), Wydawca: Society of Leukocyte Biology
    Status:
    Published
    DOI:
    10.1189/jlb.2A0715-318R - link to the publication
  2. Phorbol ester-mediated re-expression of endogenous LAT adapter in JCaM2 cells: a model for dissecting drivers and blockers of LAT transcription
    Authors:
    Karolina Marek-Bukowiec, Enrique Aguado, Arkadiusz Miazek
    Academic press:
    Genes and Immunity (rok: 2016, tom: 45452, strony: 45299), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/gene.2016.25 - link to the publication
  3. Identification of functional, short-lived isoform of linker for activation of T cells (LAT)
    Authors:
    Mikołaj Kłossowicz1*, Karolina Marek-Bukowiec1*, Mikel M. Arbulo-Echevarria3, Bożena Ścirka1, Enrique Aguado3, Arkadiusz Miazek1,2
    Academic press:
    Genes and Immunity (rok: 2014, tom: 15(7), strony: 449-456), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/gene.2014.35 - link to the publication

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