Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The neural regulation of GnRH and GnRH receptor biosynthesis in the hypothalamic-pituitary system of ewes in different physiological states.

2012/05/B/NZ4/02443

Keywords:

sheep hypothalamus anterior pituitary gland GnRH/LH GnRHR kisspeptin RFRP-3 stress

Descriptors:

  • NZ4_2: Physiology
  • NZ4_6: Endocrinology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Ciechanowska 

Number of co-investigators in the project: 10

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 926 500 PLN

Project start date (Y-m-d): 2013-02-05

Project end date (Y-m-d): 2016-02-04

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa infuzyjna CMA 402 Syringe Pump ( nr 800 3100) (2 szt.) (22 988 PLN)
  2. Bio-Rad termocykler gradientowy C 1000 Touch with 96-Deep Well Reaction Module (2 szt.) (96 000 PLN)
  3. THERMO SCIENTIFIC - Spektrofotometryczny czytnik LABSYSTEMS MULTISKAN GO (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (5)
  1. Effects of CRH and CRH antagonist on biosynthesis of GnRH and GnRH receptor in the hypothalamus-pituitary unit of follicular-phase ewes and contribution of kisspeptin.
    Authors:
    Ciechanowska M, Kowalczyk M, Łapot M, Malewski T, Antkowiak B, Brytan M, Winnicka I, Przekop F
    Academic press:
    Journal of Physiology and Pharmacology , Wydawca: Polish Physiological Society
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Effect of short-term and prolonged stress on the biosynthesis of gonadotropin-releasing hormone (GnRH) and GnRH receptor (GnRHR) in the hypothalamus and GnRHR in the pituitary of ewes diring various physiological states
    Authors:
    Ciechanowska M, Łapot M, Antkowiak B, Mateusiak K, Paruszewska E, Malewski T, Paluch M, Przekop F
    Academic press:
    Animal Reproduction Science (rok: 2016, tom: 174, strony: 66-72), Wydawca: Elseviere Science
    Status:
    Published
    DOI:
    10.1016/j.anireprosci.2016.09.006 - link to the publication
  3. The central effect of β-endorphin and naloxone on the biosynthesis of GnRH and GnRH receptor (GnRHR) in the hypothalamic-pituitary unit of follicular-phase ewes.
    Authors:
    Ciechanowska M, Łapot M, Mateusiak K, Paruszewska E, Malewski T, Krawczyńska A, Przekop F
    Academic press:
    Reproduction in Domestic Animals (rok: 2016, tom: 51, strony: 555-561), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/rda.12719 - link to the publication
  4. Biosynthesis of gonadotropin-releasing hormone (GnRH) and GnRH receptor (GnRHR) in hypothalamic-pituitary unit of anestrous and cyclic ewes.
    Authors:
    Ciechanowska M, Łapot M, Mateusiak K, Paruszewska E, Malewski T, Przekop F
    Academic press:
    Canadian Journal of Physiology and Pharmacology (rok: 2017, tom: 95, strony: 178-184), Wydawca: NRC Research Press
    Status:
    Published
    DOI:
    10.1139/cjpp-2016-0137 - link to the publication
  5. The influence of dopaminergic system inhibition on biosynthesis of gonadotropin-releasing hormone (GnRH) and GnRH receptor in anestrous sheep; hierarchical role of kisspeptin and RFamide-releated peptide-3 (RFRP-3).
    Authors:
    Ciechanowska M, Łapot M, Paruszewska E, Radawiec W, Przekop F.
    Academic press:
    Reproduction, Fertility and Development (rok: 2017, tom: ahead of print, strony: ahead of print), Wydawca: Csiro Publishing
    Status:
    Published
    DOI:
    10.1071/RD16309 - link to the publication
  6. Biosynthesis of GnRH and GnRH receptor in the hypothalamic-pituitary unit of follicular-phase ewes after modulation of GABAA receptor activity.
    Authors:
    Łapot M, Ciechanowska M, Mateusiak K, Paruszewska E, Malewski T, Przekop F
    Academic press:
    Reproductive Biology , Wydawca: Elsevier Science
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Changes in GnRH and GnRH receptor biosynthesis in the hypothalamus-pituitary unit of anestrous ewes after infusion of GnRH into the third cerebral ventricle.
    Authors:
    Magdalena Łapot, Franciszek Przekop, Edyta Paruszewska, Bożena antkowiak, Tadeusz Malewski, Magdalena Ciechanowska
    Conference:
    13th INTERNATIONAL CONGRESS OF POLISH NEUROSCIENCE SOCIETY (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 28-31 August
    Status:
    Published
  2. Mechanisms of central neural regulation of GnRH/LH secretion under short and prolonged stress in the hypothalamic-pituitary unit of ewes in different stages of reproduction.
    Authors:
    Magdalena Ciechanowska, Magdalena Łapot, Bożena Antkowiak, Krystyna Mateusiak, Edyta Paruszewska, Małgorzata Paluch, Franciszek Przekop
    Conference:
    12th INTERNATIONAL CONGRESS OF THE POLISH NEUROSCIENCE SOCIETY (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8 September
    Status:
    Published
  3. Molecular mechanisms participating in inhibition of GnRH/LH secretion induced by CRH.
    Authors:
    Magdalena Ciechanowska, Magdalena Łapot, Edyta Paruszewska, Marek Brytan, Franciszek Przekop
    Conference:
    13th INTERNATIONAL CONGRESS OF THE POLISH NEUROSCIENCE SOCIETY (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 28-31 August
    Status:
    Published
  4. The influence of dopaminergic system inhibition on kisspeptin and RFamide-related petide-3 transcripts and gonadotropin releasing hormone/receptor or proteins in anestrous ewes.
    Authors:
    Magdalena Łapot, Magdalena Ciechanowska, Marek Kowalczyk, Krystyna Mateusiak, Małgorzata Paluch, Bożena Antkowiak, Franciszek Przekop
    Conference:
    12th INTERNATIONAL CONGRESS OF THE POLISH NEUROSCIENCE SOCIETY (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8 September
    Status:
    Published
  5. The central effect of β-endorphin and naloxone on kisspeptin and RFamide-related peptide-3 – the hypothalamic networks signaling gonadotropin-releasing hormone neurons in sheep.
    Authors:
    Edyta Paruszewska, Magdalena Ciechanowska, Magdalena Łapot, Krystyna Mateusiak, Małgorzata Nawrocka, Franciszek Przekop
    Conference:
    12th INTERNATIONAL CONGRESS OF THE POLISH NEUROSCIENCE SOCIETY (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8 September
    Status:
    Published

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