Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The role of astrocytes and cellular metabolism in functional compensation of degeneration of dopaminergic system in the rats brain. Analysis of expression of AMPK and energy sensing proteins in aspect of Parkinson's disease.

2012/05/B/NZ4/02599

Keywords:

astrocytes compensation Parkinson's disease metabolism energy sensing proteins AMPK

Descriptors:

  • NZ4_11: Metabolism
  • NZ3_5: Molecular neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii, Polska Akademia Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Kuter 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 621 150 PLN

Project start date (Y-m-d): 2013-02-15

Project end date (Y-m-d): 2017-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do analizy obrazu w tym karta przetwarzania obrazu oraz oprogramowanie (15 000 PLN)
  2. Kamera cyfrowa do mikroskopu (29 950 PLN)
  3. Zestaw do elektroforezy, transferu białek i immunoblottingu, obsługujący 4 żele jednocześnie (15 000 PLN)
  4. Zestaw komputerowy z oprogramowaniem, jako stanowisko pracy dla nowo zatrudnionej osoby lub kierownika projektu. (4 000 PLN)
  5. Łaźnia wodna z wytrząsaniem i regulacją temperatury (11 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (6)
  1. Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease
    Authors:
    Katarzyna Kuter, Łukasz Olech, Norbert A. Dencher
    Academic press:
    Mitochondrion (rok: 2018, tom: bd, strony: bd), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA
    Authors:
    Katarzyna Kuter, Łukasz Olech, Urszula Głowacka
    Academic press:
    Molecular Neurobiology (rok: 2018, tom: 55(4), strony: 3049-3066), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-017-0529-z - link to the publication
  3. Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration
    Authors:
    Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczna
    Academic press:
    Journal of Neurochemistry (rok: 2018, tom: brak, strony: brak), Wydawca: Willey
    Status:
    Accepted for publication
    DOI:
    10.1111/jnc.14605 - link to the publication
  1. Role of astrocytes in nigrostriatal system degeneration. HPLC analysis of dopamine and its metabolites after glia and neurons dysfunction.
    Authors:
    Urszula Głowacka, Łukasz Olech, Katarzyna Kuter
    Conference:
    Sympozjum Neurochemiczne pt. "Molecular Basis of Pathology and Therapy in Neurological Disorders" Warszawa (rok: 2014, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 20-21 listopad 2014
    Status:
    Published
    DOI:
    link to the publication
  2. Role of astrocytes in nigrostriatal system neurons degeneration.
    Authors:
    Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Jadwiga Wardas
    Conference:
    4th Asian and Oceanian Parkinson's Disease and Movement Disorders Congress (rok: 2014, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 28-30 listopad 2014
    Status:
    Published
    DOI:
    link to the publication
  3. Changes in metabolic substrates after prolonged astrocytes dysfunction and dopaminergic neurons degeneration in substantia nigra
    Authors:
    Katarzyna Kuter, Łukasz Olech, Urszula Głowacka
    Conference:
    12th International Congress of the Polish Neuroscience Society, Gdańsk, Polska (rok: 2015, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 6-8 wrzesień 2015
    Status:
    Published
    DOI:
    link to the publication
  4. Role of astrocytes in functional compensation of the motor deficits after dopaminergic nigrostriatal system degeneration in relation to early Parkinson's disease.
    Authors:
    Łukasz Olech, Urszula Głowacka, Jadwiga Wardas, Katarzyna Kuter
    Conference:
    4th Asian and Oceanian Parkinson's Disease and Movement Disorders Congress (rok: 2014, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 28-30 listopad 2014
    Status:
    Published
    DOI:
    link to the publication
  5. Effect of astrocytes prolonged dysfunction on dopaminergic system degeneration and functional compensation of motor deficits, in relation to early Parkinson's disease.
    Authors:
    Łukasz Olech, Urszula Głowacka, Katarzyna Kuter
    Conference:
    XII European Meeting on Glial Cells in Health and Disease, Bilbao, Hiszpania (rok: 2015, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 15 - 18 lipiec 2015
    Status:
    Published
    DOI:
    link to the publication
  6. Early Parkinson's Disease and mechanisms compensating for dopaminergic neurons loss – an energy metabolism point of view.
    Authors:
    Katarzyna Kuter
    Conference:
    12th International Congress of the Polish Neuroscience Society, Gdańsk, Polska (rok: 2015, ), Wydawca: Acta Neurobiologiae Exeprimentalis
    Data:
    konferencja 6-8 wrzesień 2015
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy