Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Evaluation of the synthesis and metabolism modulation of estrogens - breast cancer risk factors by new synthetic resveratrol analogues

2012/05/B/NZ7/03048

Keywords:

stilbene trans analogues sulfatase sulfotransferase 17betahydroxysteroid dehydrogenase cytochrome P450 AhR ER HER2 breast cancer

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wanda Baer-Dubowska 

Number of co-investigators in the project: 4

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 563 000 PLN

Project start date (Y-m-d): 2013-02-27

Project end date (Y-m-d): 2017-11-26

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat X CELLigance z oprogramowaniem (160 000 PLN)
  2. Mikro-wirówka (8 000 PLN)
  3. przenośny komputer z oprogramowaniem (4 000 PLN)
  4. Komora laminarna ESCO.
  5. Oprogramowanie do opracowania i analizy danych z jądrowego rezonansu magnetycznego i spektrometrii mas.
  6. UV crosslinker (9 000 PLN)
  7. Zestaw kolumn chromatograficznych z precyzyjnymi zaworami (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. 3,4,2'-trimethoxy-trans-stilbene - a potent CYP1B1 inhibitor
    Authors:
    Renata Mikstacka, Marcin Wierzchowski, Zbigniew Dutkiewicz, Agnieszka Gielara-Korzyńska, Artur Korzyński, Stanisław Sobiak, Wanda Baer-Dubowska
    Academic press:
    Medicinal Chemistry Communications (rok: 2014, tom: 5, strony: 496-501), Wydawca: RSC Publishing, Royal Society of Chemistry, Thomas Graham House, Cambridge, UK
    Status:
    Published
    DOI:
    10.1039/C3MD00317E - link to the publication
  2. Evaluation of the effect of the new methoxy-stilbenes on expression of receptors and enzymes involved in estrogen synthesis in cancer breast cells
    Authors:
    Barbara Licznerska,Hanna Szaefer,Marcin Wierzchowski,Renata Mikstacka,Katarzyna Papierska, Wanda Baer-Dubowska
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2018, tom: 444, strony: 53-62), Wydawca: Springer International Publishing AG
    Status:
    Published
    DOI:
    10.1007/s11010-017-3230-7 - link to the publication
  3. Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation
    Authors:
    Licznerska Barbara, Szaefer Hanna, Wierzchowski Marcin, Sobierajska Hanna, Baer-Dubowska Wanda
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2017, tom: 425, strony: 169-179), Wydawca: Springer International Publishing AG
    Status:
    Published
    DOI:
    10.1007/s11010-016-2871-2 - link to the publication
  1. Methoxy-stilbenes modulate the Ah receptor and cytochromes P450 expression in breast epithelial cells MCF10A
    Authors:
    Barbara licznerska, Hanna Szaefer, Wanda Baer-Dubowska
    Conference:
    Cancer Prevention Frontiers in Cancer Prevention: Fulfilled Promises, Translational Challenges and Futrue Directions (rok: 2015, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 24-26.06.2015
    Status:
    Published
    DOI:
    link to the publication
  2. The effect of synthetic methoxy derivatives of resveratrol on the expression of enzymes involved in synthesis of estrogens in breast cancer cells.
    Authors:
    2. Hanna Szaefer, Barbara Licznerska, Marcin Wierzchowski, Wanda Baer-Dubowska
    Conference:
    FEBS Meeting 2017 (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja September 4-10
    Status:
    Published
    DOI:
    link to the publication
  3. Methoxy-trans-stilbenes as estrogen modulators in breast epithelial cells
    Authors:
    Barbara Licznerska, Hanna Szaefer, Hanna Sobierajska, and Wanda Baer-Dubowska
    Conference:
    Resverarol 2015 Regional Meeting (rok: 2015, ), Wydawca: Université de Bourgogne Maison des Sciences de l'Homme Esplanade Erasme 21000 DIJON, France
    Data:
    konferencja 02-03.11.2015
    Status:
    Published
  4. Resveratrol and methoxy derivatives modulate ERα and CYP450 via AhR expression in breast epithelial cells
    Authors:
    Barbara Licznerska, Hanna Szaefer, Hanna Sobierajska, Wanda Baer-Dubowska
    Conference:
    4th International Conference on Resveratrol and Health, Taipei, Taiwan (rok: 2016, ), Wydawca: Taipei Medical University
    Data:
    konferencja 17-19.11.2016
    Status:
    Published

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