Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mathematical and computational models of cell cycle regulation and spatial paracrine regulation in biological cells, importance of stochastic effects

2012/05/B/ST6/03472

Keywords:

intercellular comunication and regulation spatial effects modelling and simulation

Descriptors:

  • ST7_3: Simulation engineering and modelling
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

ST6 - Computer science and informatics: informatics and information systems, computer science, scientific computing, intelligent systems

Host institution :

Politechnika Śląska, Wydział Automatyki, Elektroniki i Informatyki

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Fujarewicz 

Number of co-investigators in the project: 8

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 777 670 PLN

Project start date (Y-m-d): 2013-03-18

Project end date (Y-m-d): 2016-09-17

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputery przenośne (2 szt.) (12 000 PLN)
  2. Komputer przenośny (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (19)
  • Book publications / chapters in book publications (6)
  1. Analysis options for high-throughput sequencing in miRNA expression profiling
    Authors:
    Stokowy T, Eszlinger M, Swierniak M, Fujarewicz K, Jarzab B, Paschke R, Krohn K
    Academic press:
    BMC Research Notes (rok: 2014, tom: 7(144), strony: 45303), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/1756-0500-7-144 - link to the publication
  2. Connecting radiation-induced bystander effects and senescence to improve radiation response prediction
    Authors:
    Jan Poleszczuk, Aleksandra Krzywoń, Maria Wideł, Urszula Foryś
    Academic press:
    Radiation Research (rok: 2015, tom: 183, strony: 571-577), Wydawca: Radiation Research Society
    Status:
    Published
    DOI:
    10.1667/RR13907.1 - link to the publication
  3. On the sensitivity of feature ranked lists for large-scale biological data
    Authors:
    Danuta Gaweł, Krzysztof Fujarewicz
    Academic press:
    Mathematical Biosciences and Engineering (rok: 2013, tom: 10(3), strony: 667-690), Wydawca: American Institute of Mathematical Sciences
    Status:
    Published
    DOI:
    10.667 - link to the publication
  4. The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status
    Authors:
    Widel M, Lalik A, Krzywon A, Poleszczuk J, Fujarewicz K, Rzeszowska-Wolny J
    Academic press:
    Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis (rok: 2015, tom: 778, strony: 61-70), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrfmmm.2015.06.003 - link to the publication
  5. Global Gene Expression Profiling in Three Tumor Cell Lines Subjected to Experimental Cycling and Chronic Hypoxia
    Authors:
    Olbryt M, Habryka A, Student S, Jarzab M, Tyszkiewicz T, Lisowska K
    Academic press:
    Plos One (rok: 2014, tom: 9(8), strony: 45302), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0105104 - link to the publication
  6. Induction of bystander effects by UVA, UVB, and UVC radiation in human fibroblasts and the implication of reactive oxygen species
    Authors:
    Widel M, Krzywon A, Gajda K, Skonieczna M, Rzeszowska-Wolny J
    Academic press:
    Free Radical Biology and Medicine (rok: 2014, tom: 68, strony: 278-287), Wydawca: Science Direct
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2013.12.021 - link to the publication
  7. Modeling the repair of DNA strand breaks caused by γ-radiation in a minichromosome
    Authors:
    Łakomiec K, Kumala S, Hancock R, Rzeszowska-Wolny J, Fujarewicz K
    Academic press:
    Physical Biology (rok: 2014, tom: 11(4), strony: 45299), Wydawca: IOP Science
    Status:
    Published
    DOI:
    10.1088/1478-3975/11/4/045003 - link to the publication
  8. Radiation Induced Bystander Effect: From in Vitro Studies to Clinical Application
    Authors:
    Maria Wideł
    Academic press:
    International Journal of Medical Physics, Clinical Engineering and Radiation Oncology (rok: 2016, tom: 5, strony: 45308), Wydawca: Scientific Research Publishing Inc.
    Status:
    Published
    DOI:
    brak - link to the publication
  9. Adjoint sensitivity analysis of a tumor growth model and its application to spatiotemporal radiotherapy optimization
    Authors:
    Krzysztof Fujarewicz, Krzysztof Łakomiec
    Academic press:
    Mathematical Biosciences and Engineering (rok: 2016, tom: 13, strony: 1131-1142), Wydawca: AIMS
    Status:
    Published
    DOI:
    10.3934/mbe.2016034 - link to the publication
  10. Parameter estimation of systems with delays via structural sensitivity analysis
    Authors:
    Fujarewicz K, Łakomiec K
    Academic press:
    Discrete and Continuous Dynamical Systems-series B (rok: 2014, tom: 19(8), strony: 2521-2533), Wydawca: American Institute of Mathematical Sciences
    Status:
    Published
    DOI:
    10.3934/dcdsb.2014.19.2521 - link to the publication
  11. Estimation of initial functions for system with delays based on adjoint sensitivity analysis
    Authors:
    Krzysztof Fujarewicz
    Academic press:
    Procedia Technology (rok: 2016, tom: 22, strony: 543-548), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.protcy.2016.01.114 - link to the publication
  12. Cross-talk between UV-exposed melanoma cells and bystander normal fibroblasts modifies direct response and bystander effects
    Authors:
    Aleksandra Krzywon, Maria Wideł, Krzysztof Fujarewicz, Magdalena Skonieczna, Joanna Rzeszowska-Wolny
    Academic press:
    Free Radical Biology & Medicine (rok: 2016, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Molecular signals of bystander effect induced by UVB radiation in human malignant melanoma cells
    Authors:
    Krzywon A, Widel M, Rzeszowska-Wolny J
    Conference:
    XVIII Gliwice Scientific Meetings (rok: 2014, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 20-21.11.2014
    Status:
    Published
    DOI:
    link to the publication
  2. A mathematical model for prediction of changes in mRNA-miRNA interference after irradiation
    Authors:
    Danuta Gaweł, Roman Jaksik, Joanna Rzeszowska-Wolny, Krzysztof Fujarewicz
    Conference:
    XVII Gliwice Scientific Meetnigs (rok: 2013, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 15-16.11.2013
    Status:
    Published
    DOI:
    link to the publication
  3. A mathematical model of changes in microrna-messenger RNA interactions after γ-irradiation of cells
    Authors:
    Gawel D, Jaksik R, Rzeszowska-Wolny J, Fujarewicz K
    Conference:
    XX National Conference on Applications of Mathematics in Biology and Medicine (rok: 2014, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 3-27.09.2014
    Status:
    Published
    DOI:
    link to the publication
  4. A model for the effects of ionizing radiation on microRNA-mediated regulation of mRNA levels in cells
    Authors:
    Dolbniak M, Jaksik R, Rzeszowska-Wolny J, Fujarewicz K
    Conference:
    19th Annual International Conference on Research in Computational Molecular Biology RECOMB 2015 (rok: 2015, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 12-15 Kwiecień
    Status:
    Published
  5. Analysis of RNA Interference Mechanisms after Ionizing Radiation. Experiment and Model.
    Authors:
    Marzena Dołbniak, Roman Jaksik, Joanna Rzeszowska-Wolny, Krzysztof Fujarewicz
    Conference:
    28th European Conference on Operational Research (rok: 2016, ), Wydawca: Politechnika Poznańska
    Data:
    konferencja 3-6 lipca
    Status:
    Published
  6. Bystander effect induced by UVA radiation in human malignant melanoma cells
    Authors:
    Krzywon A, Widel M, Rzeszowska-Wolny J
    Conference:
    1st Congress of Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09.2014
    Status:
    Published
    DOI:
    link to the publication
  7. Four Phenotype Model of Interaction Between Tumour Cells
    Authors:
    Krzeslak M, Swierniak A
    Conference:
    19th World Congress The International Federation of Automatic Control (rok: 2014, ), Wydawca: IFAC
    Data:
    konferencja 24-29.08.2014
    Status:
    Published
    DOI:
    link to the publication
  8. Proliferation and apoptosis in melanoma cells exposed to UV radiation
    Authors:
    Kala S, Krzywon A, Rzeszowska-Wolny J
    Conference:
    XVIII Gliwice Scientific Meetings (rok: 2014, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 20-21.11.2014
    Status:
    Published
    DOI:
    link to the publication
  9. Sensitivity of Feature Ranked Lists for Biological Data
    Authors:
    Fujarewicz K, Gawel D
    Conference:
    25th Nordic Conference in Mathematical statistics, NordStat, Turku, Finland (rok: 2014, ), Wydawca: University of Turku
    Data:
    konferencja 02-06.06.2014
    Status:
    Published
  10. UVA stimulates the proliferation of human tumor cells
    Authors:
    Kala S, Gajda K, Hahn P, Rzeszowska-Wolny J
    Conference:
    Gliwice Scienific Meetings 2015 (rok: 2015, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 20-21 Listopad
    Status:
    Published
  11. ADFIT - a tool for parameter estimation using adjoint sensitivity analysis
    Authors:
    Krzysztof Łakomiec, Krzysztof Fujarewicz
    Conference:
    11th International Conference Diagnostics of Processes and Systems, Łagów, 2013 (rok: 2013, ), Wydawca: Uniwersytet Zielonogórski
    Data:
    konferencja 8-11.09.2013
    Status:
    Published
  12. Bystander effect induced by UVA and UVB radiation in human malignant melanoma cells; implication of reactive oxygen species
    Authors:
    Krzywoń Aleksandra, Widel Maria, Joanna Rzeszowska- Wolny
    Conference:
    XVII Gliwice Scientific Meetnigs (rok: 2013, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 15-16.11.2013
    Status:
    Published
    DOI:
    link to the publication
  13. Induction of bystander effect in human malignant melanoma cells by diffrent spectrum of ultraviolet radiation
    Authors:
    Aleksandra Krzywoń
    Conference:
    XV International PhD Workshop OWD 2013 (rok: 2013, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 19-22.10.2013
    Status:
    Published
    DOI:
    link to the publication
  14. Parameter estimation for JAK-STAT model via sensitivity analysis
    Authors:
    Krzysztof Fujarewicz, Krzysztof Łakomiec
    Conference:
    The 10th International Workshop on Computational Systems Biology, WCSB 2013, June 10-12, Tampere, Finland (rok: 2013, ), Wydawca: Tampere University of Technology
    Data:
    konferencja 10-12.06.2013
    Status:
    Published
    DOI:
    link to the publication
  15. Optimization of spatio-temporal irradiation for mathematical models of tumour growth
    Authors:
    Fujarewicz K
    Conference:
    Mathematical Methods in Systems Biology (MMSB) (rok: 2015, ), Wydawca: University College Dublin
    Data:
    konferencja 15th - 18th June
    Status:
    Published
  16. Adjoint sensitivity analysis of mathematical models in biology
    Authors:
    Krzysztof Fujarewicz
    Conference:
    Dynamical Systems and Applications, the Conference in Honor of Prof. Avner Friedman, Łódż, 2013 (rok: 2013, ), Wydawca: Politechnika Łódzka
    Data:
    konferencja 7.05.2013
    Status:
    Published
  17. Estimation parameters of jak-stat pathway model by using adjoint sensitivity analysis
    Authors:
    Krzysztof Łakomiec, Krzysztof Fujarewicz
    Conference:
    XVII Gliwice Scientific Meetnigs (rok: 2013, ), Wydawca: Politechnika Śląska
    Data:
    konferencja 15-16.11.2013
    Status:
    Published
    DOI:
    link to the publication
  18. Identification of Systems with Delays using Structural Sensitivity Analysis
    Authors:
    Krzysztof Fujarewicz
    Conference:
    11th International Conference Diagnostics of Processes and Systems, Łagów (rok: 2013, ), Wydawca: Uniwersytet Zielonogórski
    Data:
    konferencja 8-11.09.2013
    Status:
    Published
  19. Mathematical model of bystander effect
    Authors:
    Kurasz K, Łakomiec K, Krzywon A, Fujarewicz K
    Conference:
    1st Congress of Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014 (rok: 2014, ), Wydawca: Acta Chimica Polonica
    Data:
    konferencja 9-12.09.2014
    Status:
    Published
    DOI:
    link to the publication
  1. Adjoint Sensitivity Analysis of Spatial Tumor Growth Model
    Authors:
    Łakomiec Krzysztof, Fujarewicz Krzysztof
    Book:
    Proceedings of the twenty-first national conference on applications of mathematics in biology and medicine (rok: 2015, tom: _, strony: 87-92), Wydawca: Uniwersytet Warszawski
    Status:
    Published
  2. Application of adjoint sensitivity analysis to parameter estimation of age-structured model of cell cycle
    Authors:
    Michał Jakubczak, Krzysztof Fujarewicz
    Book:
    Ewa Piętka, Pawel Badura, Jacek Kawa, Wojciech Wieclawek (eds.): Information Technologies in Medicine, Series Title: Advances in Intelligent Systems and Computing (rok: 2016, tom: 472, strony: 123-131), Wydawca: Springer International Publishing
    Status:
    Published
  3. Modele komórkowych szlaków sygnałowych i estymacja ich parametrów
    Authors:
    Fujarewicz K, Puszynski K
    Book:
    P. Pawłowski, A. Polański, A. Świerniak i P. Zielenkiewicz. (eds.): Inżynieria Biomedyczna - Podstawy i Zastosowania, Tom 10: Bioinformatyka, (rok: 2014, tom: 10, strony: 141-176), Wydawca: Akademicka Oficyna Wydawnicza EXIT
    Status:
    Published
  4. microRNA 3'-end Modification Detection Algorithm and Its Usage Example for Tissue Classification
    Authors:
    Danch-Wierzchowska M, Borys D, Stokowy T, Krohn K, Fujarewicz K
    Book:
    Pietka E., Kawa J., Wieclawek W. (eds.): Advances in Intelligent Systems and Computing (rok: 2014, tom: I, strony: 285-294), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    link to the publication
  5. Sprzężona analiza wrażliwości automatów komórkowych
    Authors:
    Łakomiec K, Fujarewicz K
    Book:
    Świerniak A., Krystek J. (eds.): Automatyzacja Procesów Dyskretnych, Teoria i Zastosowania (rok: 2014, tom: II, strony: 173-180), Wydawca: Wydawnictwo Pracowni Komputerowej Jacka Skalmierskiego
    Status:
    Published
  6. Parameter Estimation of Non-linear Models Using Adjoint Sensitivity Analysis
    Authors:
    Łakomiec K, Fujarewicz K
    Book:
    Janusz Sobecki, Veera Boonjing, Suphamit Chittayasothorn (eds.): Advanced Approaches to Intelligent Information and Database System (rok: 2015, tom: I, strony: 45301), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    link to the publication

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