Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification of mechanisms responsible for calcium homeostasis deregulation and concomitant disturbances in GABA metabolism as novel etiological factors of schizophrenia.

2012/05/D/NZ4/02982

Keywords:

schizophrenia NMDA receptor plasma membrane calcium pump GABA

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_11: Metabolism
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Boczek 

Number of co-investigators in the project: 4

Call: SONATA 3 - announced on 2012-03-15

Amount awarded: 499 200 PLN

Project start date (Y-m-d): 2013-03-11

Project end date (Y-m-d): 2016-03-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (9)
  • Book publications / chapters in book publications (1)
  1. Cross talk among PMCA, calcineurin and NFAT transcription factors in control of calmodulin gene expression in differentiating PC12 cells
    Authors:
    Tomasz Boczek, Malwina Lisek, Bozena Ferenc, Ludmila Zylinska
    Academic press:
    Biochemica et Biophysica Acta - Gene Regulatory Mechanisms (rok: 2017, tom: 1860, strony: 502-515), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2017.01.012. - link to the publication
  2. Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction.
    Authors:
    Malwina Lisek, Bozena Ferenc, Maciej Studzian, Lukasz Pulaski, Feng Guo, Ludmila Zylinska, Tomasz Boczek
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2017, tom: 11, strony: 181), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00181 - link to the publication
  3. Plasma membrane Ca(2+)-ATPase is a novel target for ketamine action.
    Authors:
    Tomasz Boczek, Malwina Lisek, Bożena Ferenc, Ludmiła Żylińska
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2015, tom: 465, strony: 312-317), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2015.08.037 - link to the publication
  4. Plasma membrane Ca2+-ATPase isoforms composition regulates cellular pH homeostasis in differentiating PC12 cells in a manner dependent on cytosolic Ca2+ elevations
    Authors:
    Tomasz Boczek, Malwina Lisek, Bożena Ferenc, Antoni Kowalski, Dariusz Stępiński, Magdalena Wiktorska, Ludmiła Żylińska
    Academic press:
    PLoS One (rok: 2014, tom: 9, strony: e102352), Wydawca: PLOS (Public Library of Science)
    Status:
    Published
    DOI:
    10.1371/journal.pone.0102352 - link to the publication
  5. Region-specific effects of repeated ketamine administration on the presynaptic GABAergic neurochemistry in rat brain.
    Authors:
    Tomasz Boczek, Malwina Lisek, Bożena Ferenc, Magdalena Wiktorska, Ivana Ivchevska, Ludmiła Żylińska
    Academic press:
    Neurochemistry International (rok: 2015, tom: 91, strony: 13-25), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.005 - link to the publication
  6. Regional brain dysregulation of Ca(2+)-handling systems in ketamine-induced rat model of experimental psychosis.
    Authors:
    Malwina Lisek, Tomasz Boczek, Bożena Ferenc, Ludmiła Żylińska
    Academic press:
    Cell and Tissue Research (rok: 2016, tom: 363, strony: 609-620), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00441-015-2332-3 - link to the publication
  7. Erratum to: Regional brain dysregulation of Ca2+-handling systems in ketamine-induced rat model of experimental psychosis.
    Authors:
    Malwina Lisek, Tomasz Boczek, Bożena Ferenc, Ludmiła Żylińska
    Academic press:
    Cell and Tissue Research (rok: 2016, tom: 363, strony: 825), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00441-016-2365-2. - link to the publication
  8. Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells.
    Authors:
    Tomasz Boczek, Malwina Lisek, Bożena Ferenc, Antoni Kowalski, Magdalena Wiktorska, Ludmiła Żylińska
    Academic press:
    BioMed Research International (rok: 2014, tom: 2014, strony: 735106), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2014/735106 - link to the publication
  9. Regulation of GAP43/calmodulin complex formation via calcineurin-dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition.
    Authors:
    Tomasz Boczek, Bożena Ferenc, Malwina Lisek, Ludmiła Żylińska
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2015, tom: 407, strony: 251-262), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11010-015-2473-4. - link to the publication
  1. PMCA3 – a mysterious isoform of calcium pump
    Authors:
    Tomasz Boczek, Ludmiła Żylińska
    Book:
    Regulation of ATPase (rok: 2016, tom: 14, strony: 47-62), Wydawca: Elsevier
    Status:
    Published

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