Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modification of glomerular filtration barrier permeability by the insulin, oxidative stress and protein kinase G type I alpha.

2012/05/B/NZ4/02587

Keywords:

podocyte insulin oxidative stress protein kinase G type I alpha filtration barrier permeability diabetes calcium

Descriptors:

  • NZ3_2: Cell physiology
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Piwkowska 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 690 910 PLN

Project start date (Y-m-d): 2013-02-12

Project end date (Y-m-d): 2016-02-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System do ilościowego PCR w czasie rzeczywistym (245 000 PLN)
  2. System typu Nanodrop (68 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. High glucose increases glomerular filtration barrier permeability by activating protein kinase G type Iα subunits in a Nox4-dependent manner.
    Authors:
    Piwkowska A, Rogacka D, Audzeyenka I, Angielski S, Jankowski M
    Academic press:
    Experimental Cell Research (rok: 2014, tom: 320, strony: 144-152), Wydawca: Elsevier Science
    Status:
    Published
    DOI:
    10.1016/j.yexcr.2013.09.005 - link to the publication
  2. Insulin increases glomerular filtration barrier permeability through dimerization of protein kinase G type Iα subunits.
    Authors:
    Piwkowska A, Rogacka D, Kasztan M, Angielski S, Jankowski M
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2013, tom: 1832, strony: 791-804), Wydawca: Elsevier Science
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2013.02.011 - link to the publication
  3. Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways.
    Authors:
    1)Rogacka D, Audzeyenka I, Rachubik P, Rychłowski M, Kasztan M, Jankowski M, Angielski S, Piwkowska A.
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2017, tom: 1863, strony: 1312-1325), Wydawca: Elsevier Science
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2017.03.002. - link to the publication
  4. Intracellular calcium signaling regulates glomerular filtration barrier permeability: role of PKGIα-dependent pathway
    Authors:
    Piwkowska A, Rogacka D, Audzeyenka I, Kasztan M, Angielski S, Jankowski M
    Academic press:
    FEBS Letters (rok: 2016, tom: 590, strony: 1739-1748), Wydawca: FEBSPRESS
    Status:
    Published
    DOI:
    10.1002/1873-3468 - link to the publication
  1. High glucose increases glomerular filtration barrier permeability through activation of protein kinase G type I alpha subunits
    Authors:
    Piwkowska A, Rogacka D, Audzeyenka I, Kasztan M, Angielski S, Jankowski M
    Conference:
    European Renal Association-European Dialysis and Transplant Association 50th Congress (rok: 2013, ), Wydawca: Oxford Journals
    Data:
    konferencja 18-21 maj 2013
    Status:
    Published
    DOI:
    link to the publication
  2. Insulin Increases Glomerular Barrier Permeability: Role of Intracellular Calcium and PKGIα-Dependent Signaling.
    Authors:
    Piwkowska A, Rogacka D, Audzeyenka I, Kasztan M, Angielski S, Jankowski M
    Conference:
    Experimental Biology (rok: 2015, ), Wydawca: FASEB
    Data:
    konferencja 28 marzec – 1 kwiecień
    Status:
    Published
    DOI:
    link to the publication
  3. Effects of PKGI-dependent pathway on glucose uptake in rat cultured podocytes.
    Authors:
    Piwkowska A, Rogacka D, Angielski S, Jankowski M
    Conference:
    European Renal Association-European Dialysis and Transplant Association 51th Congress (rok: 2014, ), Wydawca: Oxford Journals
    Data:
    konferencja 31 maj - 3 czerwciec
    Status:
    Published
    DOI:
    link to the publication
  4. Effect of insulin on PKGIα-dependent activation of BKCa in podocytes; implications for the regulation of actin cytoskeleton and filtration barrier permeability.
    Authors:
    Piwkowska A, Rogacka D, Audzeyenka I, Kasztan M, Angielski S, Jankowski M
    Conference:
    System-Level View of Cytoskeleton Function (rok: 2014, ), Wydawca: EMBO
    Data:
    konferencja 27-31 październik
    Status:
    Published
    DOI:
    link to the publication

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