Zmiana języka

Projects search

Obtaining and physicochemical studies of pharmaceuticals in the amorphous form in the area of solubility optimization, tableting process and stability

2012/05/B/NZ7/03233

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

UNIWERSYTET ŚLĄSKI, Wydział Matematyki, Fizyki i Chemii

Voivodeship: śląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marian Wilhelm Paluch

Number of co-investigators in the project: 6

Call

OPUS 3 – announced on 2012-03-15

Amount awarded
967 600 PLN
Project start date
2013-02-11
Project end date
2016-02-10
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Automatyczna tabletkarka laboratoryjna (Erweka EP-1). Cost: 260 000 PLN
  2. Przystawka wysokociśnieniowa (z automatyczną regulacją ciśnienia) do szerokopasmowego spektrometru dielektrycznego. Cost: 250 000 PLN
  3. Suszarka laboratoryjna z naturalnym obiegiem powietrza OGS60. 2 półki w standardzie, zakres temperatur +50 do 250 st.C. Cost: 3 891 PLN

Information in the final report

Publication in academic press/journals (13)

  1. The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil

    Authors:
    Wlodarski, K.; Sawicki, W.; Paluch, K.J.; Tajber, L. ; Grembecka, M.; Hawelek, L.; Wojnarowska, Z.; Grzybowska, K.; Talik, E.; Paluch, M
    Academic press:
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (year: 2014, volume: 62, pages: 132-140), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2014.05.026 – link to the publication

  2. Molecular dynamics of itraconazole at ambient and high pressure

    Authors:
    M. Tarnacka, K. Adrjanowicz, E. Kaminska, K. Kaminski, K. Grzybowska, K. Kolodziejczyk, P. Wlodarczyk, L. Hawelek, G. Garbacz, A. Kocot, M. Paluch
    Academic press:
    Phys.Chem. Chem. Phys (year: 2013, volume: 15, pages: 20742-20752), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c3cp52643g – link to the publication

  3. Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility

    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, L. Hawelek, W. Sawicki, K. Wlodarski, J. Markowski, and M. Paluch
    Academic press:
    MOLECULAR PHARMACEUTICS (year: 2014, volume: 11, pages: 4280–4290), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp500498e – link to the publication

  4. Effect of High Pressure on Crystallization Kinetics of van der Waals Liquid: An Experimental and Theoretical Study

    Authors:
    Adrjanowicz, K. ; Grzybowski, A.; Grzybowska, K; Pionteck, J. ; Paluch, M.
    Academic press:
    CRYSTAL GROWTH & DESIGN (year: 2014, volume: 14, pages: 2097-2104), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/cg500049w – link to the publication

  5. A New Way of Stabilization of Furosemide upon Cryogenic Grinding by Using Acylated Saccharides Matrices. The Role of Hydrogen Bonds in Decomposition Mechanism

    Authors:
    E. Kaminska, K. Adrjanowicz, K. Kaminski, P. Wlodarczyk, L. Hawelek, K. Kolodziejczyk, M. Tarnacka, D. Zakowiecki, I. Kaczmarczyk-Sedlak, J. Pilch, and M. Paluch
    Academic press:
    MOLECULAR PHARMACEUTICS (year: 2013, volume: 10, pages: 1824–1835), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp300606p – link to the publication

  6. Molecular Dynamics of the Supercooled Pharmaceutical Agent Posaconazole Studied via Differential Scanning Calorimetry and Dielectric and Mechanical Spectroscopies

    Authors:
    K. Adrjanowicz, K. Kaminski, P. Wlodarczyk, K. Grzybowska, M. Tarnacka, D. Zakowiecki, G. Garbacz, M. Paluch, S. Jurga
    Academic press:
    MOLECULAR PHARMACEUTICS (year: 2013, volume: 10, pages: 3934–3945), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp4003915 – link to the publication

  7. Molecular Dynamics, Physical Stability and Solubility Advantage from Amorphous Indapamide Drug

    Authors:
    Z. Wojnarowska, K. Grzybowska, L. Hawelek, M. Dulski, R. Wrzalik, I. Gruszka, M. Paluch, K. Pienkowska, W. Sawicki, P. Bujak, K. J. Paluch, L. Tajber, J. Markowski
    Academic press:
    MOLECULAR PHARMACEUTICS (year: 2013, volume: 10, pages: 3612-3627), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp400116q – link to the publication

  8. Toward Better Understanding Crystallization of Supercooled Liquids under Compression: Isochronal Crystallization Kinetics Approach

    Authors:
    Karolina Adrjanowicz, Andrzej Grzybowski, Katarzyna Grzybowska, Jürgen Pionteck, and Marian Paluch
    Academic press:
    CRYSTAL GROWTH & DESIGN (year: 2013, volume: 13, pages: 4648-4654), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/cg401274p – link to the publication

  9. Physicochemical properties of tadalafil solid dispersions – Impact of polymer on the apparent solubility and dissolution rate of tadalafil.

    Authors:
    4.Wlodarski K., Sawicki W., Haber K., Knapik J., Wojnarowska Z., Paluch M., Lepek P., Hawelek L., Tajber L.
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (year: 2015, volume: 94, pages: 106–115), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2015.04.031 – link to the publication

  10. Relaxation Dynamics and Crystallization Study of Sildenafil in the Liquid and Glassy States

    Authors:
    K. Kolodziejczyk, M. Paluch, K. Grzybowska, A. Grzybowski, Z. Wojnarowska, L. Hawelek , J. D. Ziolo
    Academic press:
    MOLECULAR PHARMACEUTICS (year: 2013, volume: 10, pages: 2270–2282), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp300479r – link to the publication

  11. Crystallization Behavior and Relaxation Dynamics of Supercooled S‑Ketoprofen and the Racemic Mixture along an Isochrone

    Authors:
    Adrjanowicz K., Kaminski K, Paluch M., Niss K.
    Academic press:
    CRYSTAL GROWTH & DESIGN (year: 2015, volume: 15, pages: 3257−3263), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.cgd.5b00373 – link to the publication

  12. Molecular Dynamics and Physical Stability of Coamorphous Ezetimib and Indapamide Mixtures

    Authors:
    Knapik J., Wojnarowska Z., Grzybowska K. Jurkiewicz K., Tajber L., Paluch M.
    Academic press:
    Molecular Pharmaceutics (year: 2015, volume: 12, pages: 3610−3619), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00334 – link to the publication

  13. Toward a Better Understanding of the Physical Stability of Amorphous Anti-Inflammatory Agents: The Roles of Molecular Mobility and Molecular Interaction Patterns.

    Authors:
    Rams-Baron M., Wojnarowska Z., Grzybowska K., Dulski M., Knapik J., Jurkiewicz K, Smolka W., Sawicki W., Ratuszna A., Paluch M.
    Academic press:
    Molecular Pharmaceutics (year: 2015, volume: 12, pages: 3628−3638), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00351 – link to the publication

« New search

Graphic design and implementation: Jakub Piotrowski