Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Obtaining and physicochemical studies of pharmaceuticals in the amorphous form in the area of solubility optimization, tableting process and stability

2012/05/B/NZ7/03233

Keywords:

Active Pharmaceutical Ingredients (APIs) the amorphous state physical and chemical stabilization molecular dynamics solubility improvement optimization of tableting process

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Śląski w Katowicach, Wydział Matematyki, Fizyki i Chemii

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marian Wilhelm Paluch 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 967 600 PLN

Project start date (Y-m-d): 2013-02-11

Project end date (Y-m-d): 2016-02-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Suszarka laboratoryjna z naturalnym obiegiem powietrza OGS60. 2 półki w standardzie, zakres temperatur +50 do 250 st.C (3 891 PLN)
  2. Przystawka wysokociśnieniowa (z automatyczną regulacją ciśnienia) do szerokopasmowego spektrometru dielektrycznego (250 000 PLN)
  3. Automatyczna tabletkarka laboratoryjna (Erweka EP-1) (260 000 PLN)

Information in the final report

  • Publication in academic press/journals (22)
  1. Relaxation Dynamics and Crystallization Study of Sildenafil in the Liquid and Glassy States
    Authors:
    K. Kolodziejczyk, M. Paluch, K. Grzybowska, A. Grzybowski, Z. Wojnarowska, L. Hawelek , J. D. Ziolo
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 2270–2282), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp300479r - link to the publication
  2. Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility
    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, L. Hawelek, W. Sawicki, K. Wlodarski, J. Markowski, and M. Paluch
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2014, tom: 11, strony: 4280–4290), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp500498e - link to the publication
  3. Physicochemical properties of tadalafil solid dispersions – Impact of polymer on the apparent solubility and dissolution rate of tadalafil.
    Authors:
    4.Wlodarski K., Sawicki W., Haber K., Knapik J., Wojnarowska Z., Paluch M., Lepek P., Hawelek L., Tajber L.
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2015, tom: 94, strony: 106–115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2015.04.031 - link to the publication
  4. Toward a Better Understanding of the Physical Stability of Amorphous Anti-Inflammatory Agents: The Roles of Molecular Mobility and Molecular Interaction Patterns.
    Authors:
    Rams-Baron M., Wojnarowska Z., Grzybowska K., Dulski M., Knapik J., Jurkiewicz K, Smolka W., Sawicki W., Ratuszna A., Paluch M.
    Academic press:
    Molecular Pharmaceutics (rok: 2015, tom: 12, strony: 3628−3638), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00351 - link to the publication
  5. Molecular Dynamics and Physical Stability of Coamorphous Ezetimib and Indapamide Mixtures
    Authors:
    Knapik J., Wojnarowska Z., Grzybowska K. Jurkiewicz K., Tajber L., Paluch M.
    Academic press:
    Molecular Pharmaceutics (rok: 2015, tom: 12, strony: 3610−3619), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00334 - link to the publication
  6. Molecular Dynamics of the Supercooled Pharmaceutical Agent Posaconazole Studied via Differential Scanning Calorimetry and Dielectric and Mechanical Spectroscopies
    Authors:
    K. Adrjanowicz, K. Kaminski, P. Wlodarczyk, K. Grzybowska, M. Tarnacka, D. Zakowiecki, G. Garbacz, M. Paluch, S. Jurga
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 3934–3945), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp4003915 - link to the publication
  7. A New Way of Stabilization of Furosemide upon Cryogenic Grinding by Using Acylated Saccharides Matrices. The Role of Hydrogen Bonds in Decomposition Mechanism
    Authors:
    E. Kaminska, K. Adrjanowicz, K. Kaminski, P. Wlodarczyk, L. Hawelek, K. Kolodziejczyk, M. Tarnacka, D. Zakowiecki, I. Kaczmarczyk-Sedlak, J. Pilch, and M. Paluch
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 1824–1835), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp300606p - link to the publication
  8. Molecular dynamics of itraconazole at ambient and high pressure
    Authors:
    M. Tarnacka, K. Adrjanowicz, E. Kaminska, K. Kaminski, K. Grzybowska, K. Kolodziejczyk, P. Wlodarczyk, L. Hawelek, G. Garbacz, A. Kocot, M. Paluch
    Academic press:
    Phys.Chem. Chem. Phys (rok: 2013, tom: 15, strony: 20742-20752), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c3cp52643g - link to the publication
  9. Molecular Dynamics, Physical Stability and Solubility Advantage from Amorphous Indapamide Drug
    Authors:
    Z. Wojnarowska, K. Grzybowska, L. Hawelek, M. Dulski, R. Wrzalik, I. Gruszka, M. Paluch, K. Pienkowska, W. Sawicki, P. Bujak, K. J. Paluch, L. Tajber, J. Markowski
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 3612-3627), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp400116q - link to the publication
  10. Effect of High Pressure on Crystallization Kinetics of van der Waals Liquid: An Experimental and Theoretical Study
    Authors:
    Adrjanowicz, K. ; Grzybowski, A.; Grzybowska, K; Pionteck, J. ; Paluch, M.
    Academic press:
    CRYSTAL GROWTH & DESIGN (rok: 2014, tom: 14, strony: 2097-2104), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/cg500049w - link to the publication
  11. Toward Better Understanding Crystallization of Supercooled Liquids under Compression: Isochronal Crystallization Kinetics Approach
    Authors:
    Karolina Adrjanowicz, Andrzej Grzybowski, Katarzyna Grzybowska, Jürgen Pionteck, and Marian Paluch
    Academic press:
    CRYSTAL GROWTH & DESIGN (rok: 2013, tom: 13, strony: 4648-4654), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/cg401274p - link to the publication
  12. A New Way of Stabilization of Furosemide upon Cryogenic Grinding by Using Acylated Saccharides Matrices. The Role of Hydrogen Bonds in Decomposition Mechanism
    Authors:
    E. Kaminska, K. Adrjanowicz, K. Kaminski, P. Wlodarczyk, L. Hawelek, K. Kolodziejczyk, M. Tarnacka, D. Zakowiecki, I. Kaczmarczyk-Sedlak, J. Pilch, and M. Paluch
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 1824–1835), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp300606p - link to the publication
  13. Relaxation Dynamics and Crystallization Study of Sildenafil in the Liquid and Glassy States
    Authors:
    K. Kolodziejczyk, M. Paluch, K. Grzybowska, A. Grzybowski, Z. Wojnarowska, L. Hawelek , J. D. Ziolo
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 2270–2282), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp300479r - link to the publication
  14. The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil
    Authors:
    Wlodarski, K.; Sawicki, W.; Paluch, K.J.; Tajber, L. ; Grembecka, M.; Hawelek, L.; Wojnarowska, Z.; Grzybowska, K.; Talik, E.; Paluch, M
    Academic press:
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (rok: 2014, tom: 62, strony: 132-140), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2014.05.026 - link to the publication
  15. Toward a Better Understanding of the Physical Stability of Amorphous Anti-Inflammatory Agents: The Roles of Molecular Mobility and Molecular Interaction Patterns.
    Authors:
    Rams-Baron M., Wojnarowska Z., Grzybowska K., Dulski M., Knapik J., Jurkiewicz K, Smolka W., Sawicki W., Ratuszna A., Paluch M.
    Academic press:
    Molecular Pharmaceutics (rok: 2015, tom: 12, strony: 3628−3638), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00351 - link to the publication
  16. Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility
    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, L. Hawelek, W. Sawicki, K. Wlodarski, J. Markowski, and M. Paluch
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2014, tom: 11, strony: 4280–4290), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp500498e - link to the publication
  17. The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil
    Authors:
    Wlodarski, K.; Sawicki, W.; Paluch, K.J.; Tajber, L. ; Grembecka, M.; Hawelek, L.; Wojnarowska, Z.; Grzybowska, K.; Talik, E.; Paluch, M
    Academic press:
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (rok: 2014, tom: 62, strony: 132-140), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2014.05.026 - link to the publication
  18. Molecular Dynamics and Physical Stability of Coamorphous Ezetimib and Indapamide Mixtures
    Authors:
    Knapik J., Wojnarowska Z., Grzybowska K. Jurkiewicz K., Tajber L., Paluch M.
    Academic press:
    Molecular Pharmaceutics (rok: 2015, tom: 12, strony: 3610−3619), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00334 - link to the publication
  19. Crystallization Behavior and Relaxation Dynamics of Supercooled S‑Ketoprofen and the Racemic Mixture along an Isochrone
    Authors:
    Adrjanowicz K., Kaminski K, Paluch M., Niss K.
    Academic press:
    CRYSTAL GROWTH & DESIGN (rok: 2015, tom: 15, strony: 3257−3263), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.cgd.5b00373 - link to the publication
  20. Physicochemical properties of tadalafil solid dispersions – Impact of polymer on the apparent solubility and dissolution rate of tadalafil.
    Authors:
    4.Wlodarski K., Sawicki W., Haber K., Knapik J., Wojnarowska Z., Paluch M., Lepek P., Hawelek L., Tajber L.
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2015, tom: 94, strony: 106–115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2015.04.031 - link to the publication
  21. Molecular Dynamics, Physical Stability and Solubility Advantage from Amorphous Indapamide Drug
    Authors:
    Z. Wojnarowska, K. Grzybowska, L. Hawelek, M. Dulski, R. Wrzalik, I. Gruszka, M. Paluch, K. Pienkowska, W. Sawicki, P. Bujak, K. J. Paluch, L. Tajber, J. Markowski
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 3612-3627), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp400116q - link to the publication
  22. Molecular Dynamics of the Supercooled Pharmaceutical Agent Posaconazole Studied via Differential Scanning Calorimetry and Dielectric and Mechanical Spectroscopies
    Authors:
    K. Adrjanowicz, K. Kaminski, P. Wlodarczyk, K. Grzybowska, M. Tarnacka, D. Zakowiecki, G. Garbacz, M. Paluch, S. Jurga
    Academic press:
    MOLECULAR PHARMACEUTICS (rok: 2013, tom: 10, strony: 3934–3945), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp4003915 - link to the publication

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