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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms underlaying the signaling function of PKC beta I and beta II in mitochondria after cerebral ischemia

2012/05/B/NZ3/00415

Keywords:

protein kinase C (PKC) brain ischemia protein-protein interactions regenerations

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Zabłocka 

Number of co-investigators in the project: 4

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 486 333 PLN

Project start date (Y-m-d): 2013-03-18

Project end date (Y-m-d): 2016-09-17

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy (9 476 PLN)
  2. Wirówka firmy Eppendorf (19 000 PLN)
  3. Zamrażarka niskotemperaturowa -86°C seria Glacier Blue NU-9668E (50 000 PLN)
  4. Pompa perystaltyczna firmy Zalimp (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (9)
  1. Ischemia/reperfusion-induced translocation of PKCβII to mitochondria as an important mediator of a protective signaling mechanism in ischemia-resistant region of hippocampus.
    Authors:
    Krupska O., Sarnowska A., Fedorczyk B., Gewartowska M., Misicka A., Zablocka B., Beresewicz M.
    Academic press:
    Neurochemical Reserach (rok: 2017, tom: 42(8), strony: 2392-2403), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-017-2263-3. - link to the publication
  1. Proteomic analysis of PKCβII – mitochondrial substrates in PKCβII-mediated neuroprotection.
    Authors:
    Olga Poleszak, Małgorzata Beręsewicz, Ewa Sitkiewicz, Michał Dadlez, Anna Sarnowska, Barbara Zabłocka
    Conference:
    FEBS/EMBO course on Mitochondria in Life, Death and Disease, Heraklion, Grecja (rok: 2015, ), Wydawca: EMBO
    Data:
    konferencja 12-16 pazdziernik
    Status:
    Published
  2. PKC-selective inhibitors as a useful tool for studying the signal transduction in excitotoxic stress
    Authors:
    Malgorzata Beręsewicz
    Conference:
    8 th International Conference Inhibitors of Protein Kinases (rok: 2014, ), Wydawca: IBB
    Data:
    konferencja 21-25 września
    Status:
    Published
  3. Postischemic translocation of PKCbII to mitochondria is a key element in endogenous neuroprotection.
    Authors:
    Olga Poleszak, Anna Sarnowska, Ewa Sitkiewicz, Michał Dadlez, Aleksandra Misicka, Dagmara Tymecka, Barbara Zabłocka, Małgorzata Beręsewicz
    Conference:
    78th Harden Conference: Protein Kinases in Health and Disease, Winchester, Anglia (rok: 2015, ), Wydawca: Ksiazka streszczen
    Data:
    konferencja 15-18 wrzesnia
    Status:
    Published
  4. PKC beta II translocation to mitochondria as a component of endogenous neuroprotection
    Authors:
    Krupska, O.; Sarnowska, A.; Zablocka, B.; Beresewicz M.
    Conference:
    42nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back (rok: 2017, ), Wydawca: FEBS Press - Wiley
    Data:
    konferencja 10-14 wrzesnia
    Status:
    Published
  5. The neuroprotective role of PKC beta II in ischemia-reperfusion injury.
    Authors:
    Poleszak O., Beresewicz M., Kruszyńska D., Zabłocka B.,
    Conference:
    Molecular Basis of Pathology and Therapy in Neurological Disorders (rok: 2014, ), Wydawca: Folia Neuropathol. 52(3), 2014
    Data:
    konferencja 20 – 21 listopada
    Status:
    Published
    DOI:
    link to the publication
  6. Ischemia/reperfusion-induced translation of Protein Kinase C betaII to mitochondria results in phosphorylation of respiratory complex I subunit
    Authors:
    M. Beresewicz,, O. Krupska, E. Sitkiewicz, L. Charzewski, K.A. Krzysko, B. Zabłocka
    Conference:
    World Mitochondria Society: 8th World Congress on Targeting Mitochondria (rok: 2017, ), Wydawca: WMS Journal-Archives
    Data:
    konferencja 23-24 pazdziernik
    Status:
    Published
  7. PKC β s as a key element responsible for endogenous neuroprotection
    Authors:
    Olga Poleszak, Malgorzata Beresewicz , Joanna E. Kowalczyk and Barbara Zablocka
    Conference:
    Protein Kinase C Signalling in Health and Disease (rok: 2014, ), Wydawca: Biochemical Society
    Data:
    konferencja 24-25 czerwca 2014
    Status:
    Published
    DOI:
    link to the publication
  8. PKCbII in mitochondria as a potential neuroprotective factor. Proteomic strategy to elucidate protein-protein interactions involved in PKCbII signaling
    Authors:
    Olga Poleszak, Małgorzata Beręsewicz, Ewa Sitkiewicz, Michał Dadlez, Anna Sarnowska, Barbara Zabłocka
    Conference:
    4.Neurochemical Conference 2015: Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics. Warszawa, (rok: 2015, ), Wydawca: Folia Neuropathol 2015; 53 (4)
    Data:
    konferencja 22-23 października
    Status:
    Published
  9. The neuroprotective role of mitochondrial located PKC II in ischemia-reperfusion injury.
    Authors:
    Olga Poleszak, Małgorzata Beręsewicz, Ewa Sitkiewicz, Michał Dadlez, Aleksandra Misicka-Kęsik, Bartłomiej Fedorczyk, Barbara Zabłocka,
    Conference:
    Brain and Brain Pet 2015, XXVII-th International Symposium on Cerebral Blood Flow, Metabolism and Function, Vancouver, Kanada, (rok: 2015, ), Wydawca: ISCBFM
    Data:
    konferencja 27-30 czerwca
    Status:
    Published

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