Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Studies on alpha-2-adrenoceptors and imidazoline receptors heterogeneity using modern pharmacological and biochemical methods.

2012/05/N/NZ7/03544

Keywords:

mydriasis imidazoline derivatives imidazoline receptors alpha-adrenoceptors

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Raczak-Gutknecht 

Number of co-investigators in the project: 3

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 99 994 PLN

Project start date (Y-m-d): 2013-02-27

Project end date (Y-m-d): 2017-02-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Sprzęt komputerowy z oprogramowaniem do analizy i obróbki danych.
  2. Zestaw do Western Blot (10 000 PLN)
  3. przystawka fotograficzna do mikroskopu stereoskopowego (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Effect of the reference imidazoline drugs, clonidine and rihnenidine, on rat eye pupil size confirms the decisive role of α2-adrenoceptors on mydriasis
    Authors:
    Raczak-Gutknecht, J., Frąckowiak, T., Nasal, A., Rietz, J., Paszek, M., Buszewska-Forajta, M., Kaliszan, R.
    Academic press:
    International Journal of Pharmacology (rok: 2014, tom: 10, strony: 470-478), Wydawca: Asian Network for Scientific Information
    Status:
    Published
    DOI:
    10.3923/ijp.2014.470.478 - link to the publication
  2. Are alpha-2D adrenoceptor subtypes involved in rat mydriasis evoked by new imidazoline derivatives: marsanidine and 7-methylmarsanidine?
    Authors:
    Joanna Raczak-Gutknecht, Teresa Frąckowiak , Antoni Nasal , Anita Kornicka , Franciszek Sączewski, Roman Kaliszan
    Academic press:
    Dose-Response (rok: 2017, tom: 15, strony: 45300), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/1559325817701213 - link to the publication
  3. Comparative pharmacodynamic analysis of imidazoline compounds using rat model of ocular mydriasis with a test of quantitative structure-activity relationships
    Authors:
    Joanna Raczak-Gutknecht, Antoni Nasal, Teresa Frąckowiak, Anita Kornicka, Franciszek Sączewski, Renata Wawrzyniak, Łukasz Kubik, Roman Kaliszan
    Academic press:
    Journal of pharmaceutical and biomedical analysis (rok: 2017, tom: 144, strony: 122-128), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2017.03.053 - link to the publication

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