Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Development of EPR oximetry methodology for evaluation of endothelial action of drugs

2012/05/D/NZ7/02518

Keywords:

endothelium respiration EPR

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Patrycja Kaczara 

Number of co-investigators in the project: 1

Call: SONATA 3 - announced on 2012-03-15

Amount awarded: 391 482 PLN

Project start date (Y-m-d): 2013-02-11

Project end date (Y-m-d): 2016-06-10

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. CORM‐401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells
    Authors:
    Kaczara P, Proniewski B, Lovejoy C, Kus K, Motterlini R, Abramov AY, Chlopicki S
    Academic press:
    The FEBS Journal (rok: 2018, tom: 285, strony: 1346-1358), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Status:
    Published
    DOI:
    10.1111/febs.14411 - link to the publication
  2. Carbon monoxide shifts energetic metabolism from glycolysis to oxidative phosphorylation in endothelial cells
    Authors:
    Kaczara P, Motterlini R, Kus K, Zakrzewska A, Abramov AY, Chlopicki S
    Academic press:
    FEBS Letters (rok: 2016, tom: 590, strony: 3469-3480), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Status:
    Published
    DOI:
    10.1002/1873-3468.12434 - link to the publication
  3. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBK Ca channels
    Authors:
    Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chłopicki S
    Academic press:
    Biochimica et Biophysica Acta - Bioenergetics (rok: 2015, tom: 1847, strony: 1297-1309), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2015.07.004 - link to the publication
  4. Comparative endothelial profiling of doxorubicin and daunorubicin in cultured endothelial cells.
    Authors:
    Wojcik T, Buczek E, Majzner K, Kolodziejczyk A, Miszczyk J, Kaczara P, Kwiatek W, Baranska M, Szymonski M, Chlopicki S.
    Academic press:
    Toxicology in Vitro (rok: 2015, tom: 29, strony: 512-521), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2014.12.009 - link to the publication
  1. Carbon monoxide regulates endothelial cells bioenergetics
    Authors:
    Kaczara P, Motterlini R, Zakrzewska A, Abramov AY, Chłopicki S
    Conference:
    VII Seminarium JCET, 24rd Kraków Conference on Endothelium (rok: 2016, ), Wydawca: JCET
    Data:
    konferencja 19-21 czerwcz 2016
    Status:
    Published
  2. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: a role for mitoBKCa channels
    Authors:
    Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chłopicki S
    Conference:
    VI Seminarium JCET, 23rd Kraków Conference on Endothelium (rok: 2015, ), Wydawca: JCET
    Data:
    konferencja 11-14 czerwca 2015
    Status:
    Published
  3. Carbon monoxide regulates endothelial cells bioenergetics
    Authors:
    Kaczara P, Motterlini R, Zakrzewska A, Abramov AY, Chłopicki S
    Conference:
    19th European Bioenergetics Conference (EBEC) (rok: 2016, ), Wydawca: EBEC
    Data:
    konferencja 2 - 7 lipca 2016
    Status:
    Published
  4. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: a role for mitoBKCa channels
    Authors:
    Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chłopicki S
    Conference:
    Metabolism in Cancer and Stromal Cells (rok: 2015, ), Wydawca: VIB Conference Series
    Data:
    konferencja 8 - 10 września 2015
    Status:
    Published
  5. EPR oximetry in estimating physiological state of aorta – ex vivo and in vitro study
    Authors:
    Kaczara P, Panz T, Chłopicki S
    Conference:
    IX International Workshop on EPR (ESR) In Biology and Medicine (rok: 2013, ), Wydawca: IX International Workshop on EPR (ESR) In Biology and Medicine
    Data:
    konferencja 7-10 października 2013
    Status:
    Published
  6. Effects of carbon monoxide released by CORM-401 on oxidative phosphorylation and glycolysis in endothelial cells
    Authors:
    Kaczara P, Foresti R, Motterlini R, Chłopicki S
    Conference:
    5th World Congress on Targeting Mitochondria (rok: 2014, ), Wydawca: World Mitochondria Society
    Data:
    konferencja 29 - 31 października 2014
    Status:
    Published

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