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Information on the principal investigator and host institution

Information of the project and the call

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New regulatory mechanisms of autoimmune demyelination dependent on non-coding RNA

2012/04/A/NZ6/00423

Keywords:

Immunoregulation demyelination multiple sclerosis ncRNA

Descriptors:

  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski z Oddziałem Stomatologicznym

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Selmaj 

Number of co-investigators in the project: 6

Call: MAESTRO 2 - announced on 2011-12-15

Amount awarded: 3 000 000 PLN

Project start date (Y-m-d): 2012-10-08

Project end date (Y-m-d): 2017-12-07

Project duration:: 62 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (13)
  • Book publications / chapters in book publications (1)
  1. Multiple sclerosis: Serum-derived exosomes express myelin proteins.
    Authors:
    Galazka G, Mycko MP, Selmaj I, Raine CS, Selmaj KW.
    Academic press:
    Multiple Sclerosis (rok: 2017, tom: 135245851769659, strony: 45301), Wydawca: Sage
    Status:
    Published
    DOI:
    10.1177/1352458517696597 - link to the publication
  2. Insights into multiple sclerosis provided by non-coding RNAs: meeting summary from the symposium "non-coding RNAs in autoimmune disorders of the central nervous system"
    Authors:
    Macin P. Mycko, HL Weiner, Krzysztof W. Selmaj
    Academic press:
    Multiple Sclerosis (rok: 2014, tom: -, strony: -), Wydawca: Multiple Sclerosis
    Status:
    Published
    DOI:
    10.1177/1352458514521518 - link to the publication
  3. The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.
    Authors:
    Selmaj I, Mycko MP, Raine CS, Selmaj KW.
    Academic press:
    J neuroimmunology (rok: 2017, tom: 306, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2017.02.002 - link to the publication
  4. Plasmocytoid dendritic cell deficit of early response to toll-like receptor 7 agonist stimulation in multiple sclerosis patients.
    Authors:
    Mycko MP, Cwiklinska H, Cichalewska M, Matysiak M, Lewkowicz P, Sliwinska B, Selmaj I, Selmaj KW.
    Academic press:
    Clin Immunol (rok: 2014, tom: 153, strony: 211-219), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.clim.2014.04.016 - link to the publication
  5. miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40
    Authors:
    2.Mycko MP, Cichalewska M, Cwiklinska H, Selmaj KW
    Academic press:
    J Neurosci (rok: 2015, tom: 35(50), strony: 16504-16515), Wydawca: Journal of Neurosciences
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.2830-15.2015. - link to the publication
  6. Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination
    Authors:
    1.Lewkowicz P, Cwiklińska H, Mycko MP, Cichalewska M, Domowicz M, Lewkowicz N, Jurewicz A, Selmaj KW
    Academic press:
    J Neurosci. (rok: 2015, tom: 35(19), strony: 7521-7537), Wydawca: Journal of neurosciences
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.4794-14.2015 - link to the publication
  7. Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis.
    Authors:
    Selmaj I, Cichalewska M, Namiecinska M, Galazka G, Horzelski W, Selmaj KW, Mycko MP.
    Academic press:
    Ann Neurol (rok: 2017, tom: 81, strony: 703-717), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ana.24931 - link to the publication
  1. MicroRNA-155 regulates T helper cell autoimmunity during autoimmune demyelination via Hsp40 genes expression
    Authors:
    Maria Cichalewska, Marcin P. Mycko, Hanna Ćwiklińska, Beata Śliwińska, Krzysztof W. Selmaj
    Conference:
    ECTRIMS (rok: 2013, ), Wydawca: Multiple Sclerosis Journal
    Data:
    konferencja 2-5.OCT
    Status:
    Published
    DOI:
    link to the publication
  2. Serum exosomal microRNA profiling reveals new biomarkers of MS
    Authors:
    Igor Selmaj, Magdalena Namiecińska, Maria Cichalewska, Hanna Ćwiklińska, CS Raine, Krzysztof Selmaj, Marcin P. Mycko
    Conference:
    European Academy of Neurology (rok: 2016, ), Wydawca: European Journal of Neurology
    Data:
    konferencja JUNE
    Status:
    Published
    DOI:
    link to the publication
  3. microRNA as a therapeutic traget in Multiple Sclerosis
    Authors:
    Marcin P. Mycko, Maria Cichalewska, Hanna Ćwiklińska, Beata Śliwińska, Krzysztof Selmaj
    Conference:
    Amerykańska Akademia neurologiczna (rok: 2013, ), Wydawca: 65th Annual Meeting of the American Academy of Neurology
    Data:
    konferencja 16-23 MAR
    Status:
    Published
    DOI:
    link to the publication
  4. Exosomal RNA signature in multiple sclerosis patients
    Authors:
    Igor Selmaj, Magdalena Mariasiewicz, Krzysztof Selmaj, Marcin P Mycko
    Conference:
    ECTRIMS (rok: 2015, ), Wydawca: Multiple Sclerosis Journal
    Data:
    konferencja 7-10 OCT
    Status:
    Published
  5. Non-coding RNA regulation of autoimmune mechanisms of MS
    Authors:
    Marcin P Mycko
    Conference:
    Congress of the European Academy of Neurology (rok: 2015, ), Wydawca: European Journal of Neurology
    Data:
    konferencja JUNE
    Status:
    Published
  6. RNA-induced silencing complex (RISC) determined miRNA abnormalities in autoimmune demyelination
    Authors:
    Przemysław lewkowicz, Hanna Ćwiklińska, Marcin P Mycko, Maria Cichalewska, Małgorzata Domowicz, Natalia Lewkowicz, Anna Jurewiczm Krzysztof Semaj
    Conference:
    ECTRIMS (rok: 2015, ), Wydawca: Multiple Sclerosis Journal
    Data:
    konferencja 7-10 OCT
    Status:
    Published
  7. Exosomal RNA sequences as biomarkers of MS
    Authors:
    Igor Selmaj, Krzysztof Selmaj, Magdalena Mariasiewicz, Marcin P Mycko
    Conference:
    European Academy of Neurology (rok: 2015, ), Wydawca: European Journal of Neurology
    Data:
    konferencja JUNE
    Status:
    Published
  8. Exosomal miRNA as Biomarkers for Disease Activity in RR MS
    Authors:
    Krzysztof Selmaj, Igor Selmaj, Magdalena Namiecińska, Maria Cichalewska, Marcin P Mycko
    Conference:
    65th Annual Meeting of the American Academy of Neurology (rok: 2016, ), Wydawca: Neurology
    Data:
    konferencja April
    Status:
    Published
  9. Myelin lipids attenuate Th17 cell during autoimmune demyelination
    Authors:
    Marcin P. Mycko, Beata Śliwińska, Maria Cichalewska, Hanna Ćwiklińska, Raine CS, Krzysztof Selmaj
    Conference:
    European Academy of Neurology (rok: 2016, ), Wydawca: European Journal of Neurology
    Data:
    konferencja JUNE
    Status:
    Published
    DOI:
    link to the publication
  10. Serum exosomes as biomarkers of multiple sclerosis
    Authors:
    Igor Selmaj, Magdalena Namiecińska, Maria Cichalewska, Grazyna Gałązka, Krzysztof Selmaj
    Conference:
    ECTRIMS 2016 (rok: 2016, ), Wydawca: Multiple Sclerosis Journal
    Data:
    konferencja 14-17 sep
    Status:
    Published
    DOI:
    link to the publication
  11. mir-155 controls T helper cell 17 development during autoimmune demyelination via Hsp40 gens expression
    Authors:
    Maria Cichalewska, Marcin P. Mycko, Hanna Ćwiklińska, Krzysztof Selmaj
    Conference:
    International Congress of Immunology (rok: 2016, ), Wydawca: European Journal of Immunology
    Data:
    konferencja 21-26 AUG
    Status:
    Published
    DOI:
    link to the publication
  12. MicroRNA control of an experimantal autoimmune encephalomyelitis
    Authors:
    Marcin P. Mycko, Maria Cichalewska, Hanna Ćwiklińska, Beata Śliwińska, Krzysztof Selmaj
    Conference:
    ECTRIMS (rok: 2013, ), Wydawca: Multiple Sclerosis Journal
    Data:
    konferencja 2-5.OCT
    Status:
    Published
    DOI:
    link to the publication
  13. Novel mechanism of autoimmune demyelination regulation via mir-155-3p and heat shock protein 40
    Authors:
    Maria Cichalewska, Marcin P Mycko, Krzysztof Selmaj
    Conference:
    ECTRIMS (rok: 2015, ), Wydawca: MULTIPLE SCLEROSIS JOURNAL
    Data:
    konferencja 7-10 OCT
    Status:
    Published
  1. Małe niekodujace RNA w stwardnieniu rozsianym
    Authors:
    Marcin P. Mycko, Maria Cichalewska, Krzysztof Selmaj
    Book:
    Stwardnienie rozsiane (rok: 2013, tom: -, strony: 45620), Wydawca: Termedia
    Status:
    Published
    DOI:
    link to the publication

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