Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of glioma-derived signaling molecules in polarization of macrophages and shaping immune microenvironment

2012/04/A/NZ3/00630

Keywords:

glioma-microglia interactions tumor invasion macrophage polarization tumor infiltrating macrophages integrin ligands,glioma-initiating stem cells stem cells

Descriptors:

  • NZ1_1: Molecular biology
  • NZ5_3: Pathogenesis of human diseases
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

INSTYTUT BIOLOGII DOŚWIADCZALNEJ PAN IM.M.NENCKIEGO

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bożena Kamińska-Kaczmarek 

Number of co-investigators in the project: 8

Call: MAESTRO 2 - announced on 2011-12-15

Amount awarded: 2 887 700 PLN

Project start date (Y-m-d): 2012-09-18

Project end date (Y-m-d): 2017-09-17

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. wyposażenie zestawu do immunomagnetycznej separacji komórek.
  2. Wirowka szybkoobrotowa z chłodzeniem i rotorami do płytek PCR i Taqman arrays (120 000 PLN)
  3. Kamera do mikoroskopu fluorescencyjnego z oprogramowaniem i stacją roboczą (60 000 PLN)
  4. aparat do elektroforezy i transferu białek z zasilaczami (160 000 PLN)
  5. System do separacji immunomagnetycznej komórek i płytka magnetyczna do izolacji RNA w formacie płytkowym (120 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (1)
  1. Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas
    Authors:
    Dr. Anna Gieryng , Mrs. Dominika Pszczolkowska , Dr. Katarzyna Bocian , Michal Dabrowski , Mr. Wenson D Rajan , Dr. Michal Kloss , Jakub Mieczkowski
    Academic press:
    Scientific Reports (tom: SREP-17-35871, strony: ), Wydawca: Nature Publishing Group
    Status:
    Accepted for publication
  2. Tumour-processed osteopontin and lactadherin drive the pro-tumorigenic polarization of microglia and glioma progression
    Authors:
    Aleksandra Ellert-Miklaszewska#, Pawel Wisniewski#, Magdalena Kijewska#, Paweł Gajdanowicz, Dominika Pszczolkowska, Piotr Przanowski, Michal Dabrowski, Marta Maleszewska, Bozena Kaminska*
    Academic press:
    Oncogene (rok: 2016, tom: 35(50):, strony: 6366-6377), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/onc.2016.55 - link to the publication
  3. Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma
    Authors:
    Jakub Mieczkowski1#, Marta Kocyk1,2#, Pawel Nauman3, Konrad Gabrusiewicz1, Małgorzata Sielska1, Piotr Przanowski1, Marta Maleszewska1, Wenson D. Rajan1, Dominika Pszczolkowska1, Tomasz Tykocki3, Wieslawa Grajkowska4, Katarzyna Kotulska5, Marcin Roszkowski6, Boguslaw Kostkiewicz7, Bozena Kaminska1#
    Academic press:
    Oncotarget (rok: 2015, tom: 6, strony: 33077-90), Wydawca: Impactjournals.com
    Status:
    Published
    DOI:
    10.18632/oncotarget.5310 - link to the publication
  4. Immune microenvironment of gliomas.
    Authors:
    Gieryng A, Pszczolkowska D, Walentynowicz KA, Rajan WD, Kaminska B.
    Academic press:
    Laboratory Investigation (rok: 2017, tom: 97(5), strony: 498-518), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/labinvest.2017.19. - link to the publication
  5. Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation.
    Authors:
    Kaminska B, Mota M, Pizzi M.
    Academic press:
    Biochim Biophys Acta. 2016 Mar;1862(3):339-51. (rok: 2016, tom: 1862, strony: 339-51), Wydawca: Elsevier
    Status:
    Published
  6. The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma.
    Authors:
    Kijewska M, Kocyk M, Kloss M, Stepniak K, Korwek Z, Polakowska R, Dabrowski M, Gieryng A, Wojtas B, Ciechomska IA, Kaminska B
    Academic press:
    Oncotarget (rok: 2016, tom: 8, strony: 16340-16355), Wydawca: www.impactjournals.com/oncotarget
    Status:
    Published
    DOI:
    10.18632/oncotarget.14092 - link to the publication
  1. Microglia in gliomas: friend or foe?
    Authors:
    Bozena Kaminska
    Book:
    Glioma Cell Biology (rok: 2014, tom: X, strony: 241-270), Wydawca: Springer-Verlag
    Status:
    Published