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The role of glioma-derived signaling molecules in polarization of macrophages and shaping immune microenvironment

2012/04/A/NZ3/00630

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ5_3: Patogeneza chorób człowieka
  • NZ6_1: Odporność swoista i nieswoista

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Bożena Kamińska-Kaczmarek

Number of co-investigators in the project: 8

Call

MAESTRO 2 – announced on 2011-12-15

Amount awarded
2 887 700 PLN
Project start date
2012-09-18
Project end date
2017-09-17
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Kamera do mikoroskopu fluorescencyjnego z oprogramowaniem i stacją roboczą. Cost: 60 000 PLN
  2. System do separacji immunomagnetycznej komórek i płytka magnetyczna do izolacji RNA w formacie płytkowym. Cost: 120 000 PLN
  3. Wirowka szybkoobrotowa z chłodzeniem i rotorami do płytek PCR i Taqman arrays. Cost: 120 000 PLN
  4. aparat do elektroforezy i transferu białek z zasilaczami. Cost: 160 000 PLN
  5. wyposażenie zestawu do immunomagnetycznej separacji komórek.

Information in the final report

Publication in academic press/journals (6)

  1. Tumour-processed osteopontin and lactadherin drive the pro-tumorigenic polarization of microglia and glioma progression

    Authors:
    Aleksandra Ellert-Miklaszewska#, Pawel Wisniewski#, Magdalena Kijewska#, Paweł Gajdanowicz, Dominika Pszczolkowska, Piotr Przanowski, Michal Dabrowski, Marta Maleszewska, Bozena Kaminska*
    Academic press:
    Oncogene (year: 2016, volume: 35(50):, pages: 6366-6377), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/onc.2016.55 – link to the publication

  2. Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

    Authors:
    Jakub Mieczkowski1#, Marta Kocyk1,2#, Pawel Nauman3, Konrad Gabrusiewicz1, Małgorzata Sielska1, Piotr Przanowski1, Marta Maleszewska1, Wenson D. Rajan1, Dominika Pszczolkowska1, Tomasz Tykocki3, Wieslawa Grajkowska4, Katarzyna Kotulska5, Marcin Roszkowski6, Boguslaw Kostkiewicz7, Bozena Kaminska1#
    Academic press:
    Oncotarget (year: 2015, volume: 6, pages: 33077-90), Publisher: Impactjournals.com
    Status:
    Published
    DOI:
    10.18632/oncotarget.5310 – link to the publication

  3. Immune microenvironment of gliomas.

    Authors:
    Gieryng A, Pszczolkowska D, Walentynowicz KA, Rajan WD, Kaminska B.
    Academic press:
    Laboratory Investigation (year: 2017, volume: 97(5), pages: 498-518), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/labinvest.2017.19. – link to the publication

  4. The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma.

    Authors:
    Kijewska M, Kocyk M, Kloss M, Stepniak K, Korwek Z, Polakowska R, Dabrowski M, Gieryng A, Wojtas B, Ciechomska IA, Kaminska B
    Academic press:
    Oncotarget (year: 2016, volume: 8, pages: 16340-16355), Publisher: www.impactjournals.com/oncotarget
    Status:
    Published
    DOI:
    10.18632/oncotarget.14092 – link to the publication

  5. Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation.

    Authors:
    Kaminska B, Mota M, Pizzi M.
    Academic press:
    Biochim Biophys Acta. 2016 Mar;1862(3):339-51. (year: 2016, volume: 1862, pages: 339-51), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2015.10.026 – link to the publication

  6. Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas

    Authors:
    Dr. Anna Gieryng , Mrs. Dominika Pszczolkowska , Dr. Katarzyna Bocian , Michal Dabrowski , Mr. Wenson D Rajan , Dr. Michal Kloss , Jakub Mieczkowski
    Status:
    Accepted for publication

Book publications / chapters in book publications (1)

  1. Microglia in gliomas: friend or foe?

    Authors:
    Bozena Kaminska
    Book:
    Glioma Cell Biology (year: 2014, volume: X, pages: 241-270), Publisher: Springer-Verlag
    Status:
    Published

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