Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms of virus transmission between cells: strategies to survive

2012/04/A/NZ1/00056

Keywords:

molecular virology virus entry cell-to-cell spread hepatitis C virus herpesviruses

Descriptors:

  • NZ6_5: Virology
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krystyna Bieńkowska-Szewczyk 

Number of co-investigators in the project: 6

Call: MAESTRO 2 - announced on 2011-12-15

Amount awarded: 2 300 000 PLN

Project start date (Y-m-d): 2012-09-06

Project end date (Y-m-d): 2018-03-05

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Przystawka do pomiaru fluorescencji do czytnika Infinite (19 000 PLN)
  2. Komora laminarna (40 000 PLN)
  3. Obiektyw HC PL APO do mikroskopu konfokalnego.
  4. Inkubator CO2 (27 000 PLN)
  5. Przystawka do pomiaru luminescencji do czytnika Infinite (21 000 PLN)
  6. rotor SW28 do ultrawirówki Beckman (113 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (10)
  1. Inhibition of apoptosis in BHV-1-infected cells depends on Us3 serine/threonine kinase and its enzymatic activity
    Authors:
    Brzozowska A, Lipińska AD, Derewońko N, Lesiak D, Rychłowski M, Rąbalski Ł, Bieńkowska-Szewczyk K
    Academic press:
    Virology (rok: 2018, tom: 513, strony: 136-145), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.virol.2017.09.029 - link to the publication
  2. Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice
    Authors:
    Krapchev VB, Rychłowska M , Chmielewska A., Zimmer K., Patel A.H.,Bienkowska-Szewczyk K
    Academic press:
    Virology (rok: 2018, tom: 519, strony: 33–41), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.virol.2018.03.026 - link to the publication
  3. Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regime elicits T cell and neutralizing antibody immune responses
    Authors:
    Chmielewska AM, Naddeo M, Capone S, Ammendola V, Hu K, Meredith L, Verhoye L, Rychlowska M, Rappuoli R, Ulmer JB, Colloca S, Nicosia A, Cortese R, Leroux-Roels G, Balfe P, Bienkowska-Szewczyk K, Meuleman P, McKeating JA, Folgori A.
    Academic press:
    Journal of Virology (rok: 2014, tom: 88, strony: 5502-5510), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.03574-13 - link to the publication
  4. Novel methods of hepatitis C treatment and prevention
    Authors:
    Chmielewska AM, Rychłowska M, Król E, Solarz K, Bieńkowska-Szewczyk K.
    Academic press:
    Postepy Higieny i Medycyny Doświadczalnej (rok: 2015, tom: 69, strony: 946-63), Wydawca: Wydawnictwo Lekarskie PZWL
    Status:
    Published
    DOI:
    10.5604/17322693.1165197 - link to the publication
  5. Orf virus (ORFV) ANK-1 protein mitochondrial localization is mediated by ankyrin repeat motifs
    Authors:
    Krzysztof Lacek , Berthilde Bauer, Krystyna Bienkowska-Szewczyk, Hanns-Joachim Rziha
    Academic press:
    Virus Genes (rok: 2014, tom: 49, strony: 68-79), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11262-014-1069-5 - link to the publication
  6. Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin
    Authors:
    Urbanowicz RA, Lacek K, Lahm A, Bienkowska-Szewczyk K, Ball JK, Nicosia A, Cortese R, Pessi A.
    Academic press:
    Journal of Peptide Science (rok: 2015, tom: 21, strony: 743-9), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/psc.2802 - link to the publication
  7. How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing
    Authors:
    Koralewska N, Hoffmann W, Pokornowska M, Milewski M, Lipinska A, Bienkowska-Szewczyk K, Figlerowicz M, Kurzynska-Kokorniak A1
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 773-783), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2016_1339 - link to the publication
  8. Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation
    Authors:
    Lacek Krzysztof, Urbanowicz RA, Troise F, De Lorenzo C, Severino V, Di Maro A, Tarr AW, Ferrara F, Ploss A, Temperton N, Ball JK, Nicosia A, Cortese R, Pessi A
    Academic press:
    Journal of Biological Chemistry (rok: 2014, tom: 289, strony: 35015-28), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M114.591826 - link to the publication
  9. Tunneling nanotubes (TNT) as a novel route of cell-to-cell spread of herpesviruses
    Authors:
    Panasiuk M, Rychłowski M, Derewońko N, Bieńkowska-Szewczyk K
    Academic press:
    Journal of Virology (rok: 2018, tom: 92, strony: xx), Wydawca: American Society for Microbiology (ASM)
    Status:
    Published
    DOI:
    10.1128/JVI.00090-18. - link to the publication
  1. Infection of human cells by bovine herpesvirus (BHV-1) with restricted host range
    Authors:
    Panasiuk M, Derewonko N, Brzozowska A., Rychłowski M., Bienkowska-Szewczyk K.
    Conference:
    Viruses 2016 - At the Forefront of Virus–Host Interactions (rok: 2016, ), Wydawca: University of Basel , journal "Viruses"
    Data:
    konferencja 26-28 stycznia
    Status:
    Published
  2. Fluorescent Protein-tagged Herpesvirus (BHV-1) Mutants allow Direct Tracking of Viral Cell-to-cell spread
    Authors:
    Derewonko N, M.Rychlowski, M. Panasiuk, A. Brzozowska, J. Belkiewicz, Bienkowska-Szewczyk K
    Conference:
    BioImaging: From Cells to Molecules (rok: 2016, ), Wydawca: Cambridge Network
    Data:
    konferencja 14-15 czerwca
    Status:
    Published
  3. Herpesviruses Use Various Types Of Intercellular Connections To Spread From Cell To Cell
    Authors:
    Panasiuk M, M. Rychlowski, K. Bienkowska-Szewczyk
    Conference:
    BioImaging: From Cells to Molecules (rok: 2016, ), Wydawca: Cambridge Network
    Data:
    konferencja 14-15 czerwca
    Status:
    Published
  4. THE KINASE ACTIVITY OF BOVINE HERPESVIRUS 1 US3 IS ESSENTIALFOR ITS BIOLOGICAL FUNCTIONS
    Authors:
    Panasiuk Mirosława, Brzozowska Agnieszka, Rychłowski Michał, Jaworski Jacek, Bieńkowska- Szewczyk Krystyna
    Conference:
    4th ESVV Veterinary Herpesvirus Symposium (rok: 2013, ), Wydawca: European Society for Veterinary Virology
    Data:
    konferencja styczen 17-18
    Status:
    Published
  5. Confocal microscopy analysis reveals novel aspects of cell-to-cell spread of alphaherpesviruses
    Authors:
    N. Derewonko, M. Panasiuk, M. Rychlowski, A. Brzozowska and K. Bienkowska –Szewczyk
    Conference:
    6th European Congress of Virology (ECV2016) (rok: 2016, ), Wydawca: European Society for Virology
    Data:
    konferencja 19- 22 Oct
    Status:
    Published
  6. Aberrations in glycosylation pattern of HCV envelope protein E2 isolated from patients.
    Authors:
    Zimmer K., Rychlowska M., Bienkowska-Szewczyk K
    Conference:
    Viruses 2016 - At the Forefront of Virus–Host Interactions (rok: 2016, ), Wydawca: University of Basel and journal "Viruses"
    Data:
    konferencja 26-28 stycznia
    Status:
    Published
  7. Bovine Herpesvirus Type 1 (BHV-1) Us3 Ability to Modulate Apoptosis Depends on its Kinase Activity
    Authors:
    Brzozowska A , Derewonko N, Lipinska A, Rychlowski M, Lesiak D, Panasiuk M , Bienkowska-Szewczyk K
    Conference:
    40th Annual International Herpesvirus Workshop (rok: 2015, ), Wydawca: Conference Solutions Inc
    Data:
    konferencja lipiec 25-30
    Status:
    Published
  8. Correlation between glycosylation pattern of patient-derived HCV E1E2 glycoproteins and the response to anti-HCV standard therapy
    Authors:
    Solarz K, Rychłowska M, Czarnota A , Jackowiak P , Figlerowicz M, K. Bieńkowska-Szewczyk
    Conference:
    EASL Monothematic Conference : Translational Research in Chronic Viral Hepatitis (rok: 2013, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 12-13 listopada
    Status:
    Published
    DOI:
    link to the publication
  9. Next Generation Sequencing of three BHV-1 UL Fragments Reveals Genomic Regions Specific for 1.1 and 1.2 groups
    Authors:
    Łukasz Rąbalski , Natalia Derewonko , Krystyna Bienkowska-Szewczyk
    Conference:
    40th Annual International Herpesvirus Workshop (rok: 2015, ), Wydawca: Conference Solutions Inc
    Data:
    konferencja lipiec 25-30
    Status:
    Published
  10. BHV-1 Us3 expression causes different changes in epithelial and neuronal cells.
    Authors:
    Miroslawa Panasiuk , Agnieszka Brzozowska , Michal Rychlowski Jacek Jaworski ,Bienkowska-Szewczyk Krystyna
    Conference:
    38th International Herpesvirus Workshop (rok: 2013, ), Wydawca: Conference Solutions Inc
    Data:
    konferencja 20-25 July
    Status:
    Published
    DOI:
    link to the publication

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