Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Preparation of recombinant exopolysaccharide (EPS) depolymerase encoded by Pseudomonas aeruginosa phages and determination of its activity in biofilm degradation.

2012/04/M/NZ6/00335

Keywords:

phage exopolysaccharidase Pseudomonas aeruginosa biofilm

Descriptors:

  • NZ6_5: Virology
  • NZ6_4: Bacteriology
  • NZ1_1: Molecular biology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zuzanna Drulis-Kawa 

Number of co-investigators in the project: 7

Call: HARMONIA 2 - announced on 2011-12-15

Amount awarded: 826 800 PLN

Project start date (Y-m-d): 2012-09-04

Project end date (Y-m-d): 2016-09-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  1. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections.
    Authors:
    Danis-Wlodarczyk K, Vandenheuvel D, Jang HB, Briers Y, Olszak T, Arabski M, Wasik S, Drabik M, Higgins G, Tyrrell J, Harvey BJ, Noben JP, Lavigne R, Drulis-Kawa Z.
    Academic press:
    Scientific Reports (rok: 2016, tom: Jun 15;6, strony: 28115), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/srep28115. - link to the publication
  2. Bacteriophages and Phage-Derived Proteins - Application Approaches
    Authors:
    Drulis-Kawa Z, Majkowska-Skrobek G, Maciejewska B.
    Academic press:
    Current Medicinal Chemistry (rok: 2015, tom: 22(14), strony: 1757-73.), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867322666150209152851 - link to the publication
  3. Characterization of the newly isolated lytic bacteriophages KTN6 and KT28 and their efficacy against Pseudomonas aeruginosa biofilm.
    Authors:
    Katarzyna Danis-Wlodarczyk, Tomasz Olszak, Michal Arabski, Slawomir Wasik, Grazyna Majkowska-Skrobek, Daria Augustyniak, Grzegorz Gula, Yves Briers, Ho Bin Jang, Dieter Vandenheuvel, Katarzyna A. Duda, Rob Lavigne, Zuzanna Drulis-Kawa.
    Academic press:
    Plos One (rok: 2015, tom: 45433, strony: 45311), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0127603. - link to the publication
  4. In vitro and in vivo antibacterial activity of environmental bacteriophages against Pseudomonas aeruginosa strains from cystic fibrosis patients
    Authors:
    Olszak T., Zarnowiec P., Kaca W., Danis-Włodarczyk K., Augustyniak D., Drevinek P., de Soyza A., McClean S. and Z. Drulis-Kawa.
    Academic press:
    Applied Microbiology and Biotechnology (rok: 2015, tom: 99 (14), strony: 6021-6033), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00253-015-6492-6 - link to the publication
  5. A giant Pseudomonas phage from Poland.
    Authors:
    Drulis-Kawa Z., Olszak T., Danis K., Majkowska-Skrobek G., Ackermann HW
    Academic press:
    Archives of Virology (rok: 2014, tom: 159, strony: 567-572), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00705-013-1844-y - link to the publication
  6. Modern Therapeutic Approaches Against Pseudomonas aeruginosa Infections.
    Authors:
    Dorotkiewicz-Jach A, Augustyniak D, Olszak T, Drulis-Kawa Z.
    Academic press:
    Current Medicinal Chemistry (rok: 2015, tom: 22(14), strony: 1642-64), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867322666150417122531 - link to the publication