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New substrates for AlkB family dioxygenases. Coding properties, mutagenesis and repair of acrolein adducts to adenine and cytosine.

2012/04/M/NZ1/00068

Keywords:

DNA modification DNA repair AlkB dioxygenases cocrystallization

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Maciejewska 

Number of co-investigators in the project: 5

Call: HARMONIA 2 - announced on 2011-12-15

Amount awarded: 461 760 PLN

Project start date (Y-m-d): 2012-09-03

Project end date (Y-m-d): 2016-09-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. 1,N6-α-hydroxypropanoadenine, the acrolein adduct to adenine, is a substrate for AlkB dioxygenase
    Authors:
    Małgorzata Dylewska, Jarosław T. Kuśmierek, Tomasz Pilżys, Jarosław Poznański* and Agnieszka M. Maciejewska*
    Academic press:
    Biochemical Journal (rok: 2017, tom: 474, strony: 1837-1852), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20161008 - link to the publication
  2. Effects of Changes in Intracellular Iron Pool on AlkB-Dependent and AlkB-Independent Mechanisms Protecting E.coli Cells Against Mutagenic Action of Alkylating Agents
    Authors:
    Anna Sikora, Agnieszka M. Maciejewska, Jarosław Poznański, Tomasz Pilżys, Michał Marcinkowski, Małgorzata Dylewska, Jan Piwowarski, Wioletta Jakubczak, Katarzyna Pawlak and Elżbieta Grzesiuk
    Academic press:
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (rok: 2015, tom: 778, strony: 52-60), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrfmmm.2015.05.009 - link to the publication
  3. AlkB Dioxygenase Preferentially Repairs Protonated Substrates. Specificity Against Exocyclic Adducts and Molecular Mechanism of Action
    Authors:
    Maciejewska A.M., Poznanski J., Kaczmarska Z., Krowisz B., Nieminuszczy J., Polkowska-Nowakowska A., Grzesiuk E., Kusmierek J.T.
    Academic press:
    JOURNAL OF BIOLOGICAL CHEMISTRY (rok: 2013, tom: 288, strony: 432-441), Wydawca: American Society for Biochemistry and Molecular Biology (United States)
    Status:
    Published
    DOI:
    10.1074/jbc.M112.353342 - link to the publication

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