Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Characterization of molecular margins of cancer by MALDI Imaging Mass Spectrometry

2011/03/D/NZ4/03507

Keywords:

cancer molecular margin molecular imaging mass spectrometry bioinformatics molecular pathology

Descriptors:

  • NZ2_3: Proteomics
  • NZ4_12: Other related subjects
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Oddział w Gliwicach

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Kalinowska-Herok 

Number of co-investigators in the project: 3

Call: SONATA 2 - announced on 2011-09-15

Amount awarded: 761 000 PLN

Project start date (Y-m-d): 2012-09-06

Project end date (Y-m-d): 2017-03-05

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. aktualizacja oprogramowania FlexImaging.
  2. skaner do preparatów mikroskopowych/płytek MALDI-IMS (200 000 PLN)
  3. wytrząsarka Vortex Gene2.
  4. Wymiana lasera w spektrometrze UltraFlextreme (Bruker Daltonic) (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. MALDI Imaging Mass Spectrometry – A Novel Approach in Biomedical Research of Tissues.
    Authors:
    Kalinowska-Herok M, Pietrowska M, Walaszczyk A, Widłak P
    Academic press:
    Current Proteomics (rok: 2013, tom: 10, strony: 76-82), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/15701646112099990002 - link to the publication
  2. Tissue fixed with formalin and processed without paraffin embedding is suitable for imaging of both peptides and lipids by MALDI-IMS.
    Authors:
    Pietrowska M, Gawin M, Polańska J, Widłak P
    Academic press:
    Proteomics (rok: 2016, tom: 16, strony: 1670-1677), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/pmic.201500424 - link to the publication
  3. Detection of molecular signatures of oral squamous cell carcinoma and normal epithelium – application of a novel methodology for unsupervised segmentation of imaging mass spectrometry data.
    Authors:
    Widlak P, Mrukwa G, Kalinowska M, Pietrowska M, Chekan M, Wierzgon J, Gawin M, Drazek G, Polanska J
    Academic press:
    Proteomics (rok: 2016, tom: 16, strony: 1613–1621), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/pmic.201500458 - link to the publication
  4. Tumor molecular margins
    Authors:
    Kalinowska-Herok M, Roś M, Widłak P
    Academic press:
    NOWOTWORY Journal of Oncology (rok: 2013, tom: 63, strony: 455-461), Wydawca: VM Media sp. z o.o. VM Group sp.k.
    Status:
    Published
    DOI:
    brak - link to the publication

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