Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The function of UDP-N-acetylglucosamine transporter of Golgi apparatus in glycosylation of macromolecules

2011/03/B/NZ1/02084

Keywords:

glycosylation membrane transport UDP-N-acetylglucosamine glycoproteins Golgi apparatus

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_7: Cell engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Olczak 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 469 000 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2015-08-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. kolumna chromatograficzna GlycoSep N (10 000 PLN)
  2. kolumna chromatograficzna Hypercarb (5 000 PLN)
  3. kolumna chromatograficzna GlycoSep C (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Short N-terminal region of UDP-galactose transporter (SLC35A2) is crucial for galactosylation of N-glycans
    Authors:
    Sosicka P, Jakimowicz P, Olczak T, Olczak M
    Academic press:
    Biochem Biophys Res Commun (rok: 2014, tom: 454, strony: 486-492), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.098 - link to the publication
  2. UDP-Gal/UDP-GlcNAc chimeric transporter complements mutation defect in mammalian cells deficient in UDP-Gal transporter
    Authors:
    Olczak M, Maszczak-Seneczko D, Sosicka P, Jakimowicz P, Olczak T
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2013, tom: 434, strony: 473-478), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2013.03.098 - link to the publication
  3. UDP-N-acetylglucosamine transporter (SLC35A3) regulates biosynthesis of highly branched N-glycans and keratan sulfate
    Authors:
    Maszczak-Seneczko D, Sosicka P, Olczak T, Jakimowicz P, Majkowski M, Olczak M
    Academic press:
    Journal of Biological Chemistry (rok: 2013, tom: 288, strony: 21850-60), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M113.460543 - link to the publication
  4. UDP-N-acetylglucosamine transporter and UDP-galactose transporter form heterologous complexes in the Golgi membrane
    Authors:
    Maszczak-Seneczko D, Sosicka, P, Majkowski M; Olczak T, Olczak M.
    Academic press:
    FEBS Letters (rok: 2012, tom: 586, strony: 4082-4087), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.016 - link to the publication
  5. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) transporters form glycosylation-related complexes with mannoside acetylglucosaminyltransferases (Mgats)
    Authors:
    Maszczak-Seneczko D, Sosicka P, Kaczmarek B, Majkowski, M, Luzarowski M, Olczak T, Olczak M
    Academic press:
    Journal of Biological Chemistry (rok: 2015, tom: 290, strony: 15475-15486), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M115.636670 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy