The role of transcription factors Stat1 and Stat3 in transcriptional regulation of uba7 and jmjd3, crucial mediators of inflammation
2011/03/N/NZ1/03143
Keywords
Descriptors
- NZ1_1: Biologia molekularna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 2 – announced on 2011-09-15
- Amount awarded
- 161 000 PLN
- Project start date
- 2012-08-27
- Project end date
- 2014-02-26
- Project duration
- 18 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- mikrowirówka miniSpin (Ependorf). Cost: 4 534 PLN
Information in the final report
Publication in academic press/journals (2)
-
ISG'ylation increases stability of numerous proteins including Stat1, which prevents premature termination of immune response in LPS-stimulated microglia
- Authors:
- Piotr Przanowski, Stefan Loska, Dominik Cysewski, Michal Dabrowski, Bozena Kaminska
- Academic press:
- Neurochemistry International (year: 2017, volume: -, pages: [Epub ahead of print]), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.neuint.2017.07.013 – link to the publication
-
The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.
- Authors:
- Przanowski P, Dabrowski M, Ellert-Miklaszewska A, Kloss M, Mieczkowski J, Kaza B, Ronowicz A, Hu F, Piotrowski A, Kettenmann H, Komorowski J, Kaminska B.
- Academic press:
- Journal of Molecular Medicine (year: 2014, volume: 92, Issue 3, pages: 239-254), Publisher: SPRINGER
- Status:
- Published
- DOI:
- 10.1007/s00109-013-1090-5 – link to the publication