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Information of the project and the call

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Reconstitution of hematopoietic stem cell niche after allogeneic stem cell transplantation

2011/03/B/NZ6/04917

Keywords:

allogeneic stem cell transplantation T-regulatory lymphocytes hematopoietic stem cell niche

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Oddział w Gliwicach

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Sebastian Giebel 

Number of co-investigators in the project: 10

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 400 000 PLN

Project start date (Y-m-d): 2012-09-06

Project end date (Y-m-d): 2015-09-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (5)
  1. Immunological properties of bone marrow microenvironment 1 year after allogeneic hematopoietic stem cell transplantation.
    Authors:
    Agnieszka Ciomber, Iwona Mitrus, Wojciech Fidyk, Andrzej Smagur, Agata Chwieduk, Magdalena Głowala-Kosińska, Tomasz Czerw, Małgorzata Sobczyk-Kruszelnicka, Włodzimierz Mendrek, Maria Saduś-Wojciechowska, Jacek. Najda, Jerzy Holowiecki, Sebastian Giebel
    Academic press:
    Experimental Hematology (rok: 2016, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.exphem.2016.08.001 - link to the publication
  1. Expression of immunosuppressive protein CD47 in hematopoietic stem cells is lower in blood than in bone marrow
    Authors:
    I. Mitrus, A. Ciomber, W. Fidyk, A. Smagur, M Głowala-Kosińska, S. Giebel
    Conference:
    Stem Cells in Cancer and Regenerative Medicine (rok: 2014, ), Wydawca: EMBO
    Data:
    konferencja 8-12 października
    Status:
    Published
  2. CD274 expression on HSCs is increased after chemo- and radiotherapy
    Authors:
    Ciomber A, Mitrus I, Fidyk W, Smagur A, Głowala-Kosińska M, Giebel S
    Conference:
    Monocytes, dendritic cells and macrophages – basic research and pathophysiological aspects - 29th Annual Conference of the EMDS 2015 (rok: 2015, ), Wydawca: European Macrophage & Dendritic Cell Society
    Data:
    konferencja 11-13 września
    Status:
    Published
  3. Immunosuppressive properties of bone marrow microenvironment after allo-HSC transplanation
    Authors:
    Smagur A., Ciomber A., Mitrus I, Głowala-Kosińska M., Fidyk W., Giebel S.
    Conference:
    The Immune System and the Microenvironment - Implication for Cancer Therapy (rok: 2015, ), Wydawca: Institute for Cancer Research, The Radium Hospital, Oslo, Norway
    Data:
    konferencja 24-25 sierpnia
    Status:
    Published
  4. Increased expression of CD47 and CD274 immunosuppressive proteins on HSCs after allogeneic HSCs transplantation.
    Authors:
    A. Ciomber, I. Mitrus, W. Fidyk, A. Smagur, S. Giebel
    Conference:
    48 Zjazd PTBioch (rok: 2013, ), Wydawca: Acta Biochimica Polonica, supplement 1/2013
    Data:
    konferencja 2-5 września 2013
    Status:
    Published
    DOI:
    link to the publication
  5. The impact of proinflammatory and immunosuppressive cytokines on the expression of CD47 and CD274 on the HSCs
    Authors:
    A. Ciomber, W. Fidyk, I. Mitrus, M. Głowala-Kosińska, A. Smagur, S. Giebel
    Conference:
    XV Zjazd Towarzystwa Immunologii Doświadczalnej i Klinicznej (rok: 2014, ), Wydawca: Central European Journal of Immunology
    Data:
    konferencja 26-28 czerwca
    Status:
    Published

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