Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Graphene and nanocomplexes of graphite as a modulators of cell nutrition and expression of p53 protein in investigation with glioblastoma multiforme in vitro and in ovo.

2011/03/B/NZ9/03387

Keywords:

nutritional stress nanoparticles graphene graphite p53 protein chicken embryo cancer cells glioblastoma multiforme

Descriptors:

  • NZ9_2: Animal production
  • NZ9_13: Other related subjects
  • NZ9_7: Nutrition and food sciences

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Sawosz Chwalibóg 

Number of co-investigators in the project: 11

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 881 000 PLN

Project start date (Y-m-d): 2012-08-29

Project end date (Y-m-d): 2015-08-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Analizator wielkości cząstek nanometrycznych i potencjału Zeta z wyposażeniem (270 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Graphene functionalized with Arginine decreases the development of glioblastoma multiforme tumour in a gene depended manner
    Authors:
    Sawosz E., Jaworski S., Kutwin M., Vadalasetty K.P., Grodzik M., Wierzbicki M., Kurantowicz N., Strojny B., Hotowy A., Lipińska L., Jagiełło J., Chwalibog A.
    Academic press:
    International Journal of Molecular Science (rok: 2015, tom: 16, strony: 25214-25233), Wydawca: MDPI AG, Postfach, CH-4005 Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms161025214 - link to the publication
  2. Patent 407166 "Zawiesina nanopłatków tlenku grafenu w wodzie, jej zastosowanie i sposób otrzymywania"
    Authors:
    Sawosz E., Kutwin M., Jaworski S., Wierzbicki M., Grodzik M., Hotowy A., Lipińska L., Jagiełło J.
    Academic press:
    Biuletyn Urzędu patentowego (rok: 2014, tom: 17, strony: 14), Wydawca: Urząd Patentowy Rzeczypospolitej Polskiej
    Status:
    Published
    DOI:
    link to the publication
  3. Toxicity of different forms of graphene on the chicken embryo model.
    Authors:
    Maciej Szmidt, Ewa Sawosz, Kaja Urbańska, Sławomir Jaworski, Marta Kutwin, Anna Hotowy, Mateusz Wierzbicki, Marta Grodzik, Ludwika Lipińska, André Chwalibog
    Academic press:
    Environmental Science and Pollution Research (rok: 2016, tom: 23, strony: 19940-19948), Wydawca: SPRINGER HEIDELBERG
    Status:
    Published
    DOI:
    10.1007/s11356-016-7178-z - link to the publication
  4. In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
    Authors:
    Jaworski S., Sawosz E., Grodzik M., Winnicka A., Prasek M., Wierzbicki M., Chwalibog A.
    Academic press:
    International Journal of Nanomedicine (rok: 2013, tom: 8, strony: 413-420), Wydawca: Dove Medical Press Ltd. Albany, New Zeland
    Status:
    Published
    DOI:
    10.2147/IJN.S39456 - link to the publication
  5. Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells
    Authors:
    Hinzmann M., Jaworski S., Kutwin M., Jagiełło J., Koziński R., Wierzbicki M., Grodzik M., Lipińska L., Sawosz E., Chwalibog A.
    Academic press:
    International Journal of Nanomedicine (rok: 2014, tom: 9, strony: 2409-2417), Wydawca: Dove Medical Press Ltd. New Zeland
    Status:
    Published
    DOI:
    10.2147/IJN.S62497 - link to the publication
  6. Toxicity of pristine graphene in experiments in a chicken embryo model
    Authors:
    Sawosz E., Jaworski S., kutwin M., Hotowy A., Wierzbicki M., Grodzik M., Kurantowicz N., Strojny B., Lipińska L., Chwalibog A.
    Academic press:
    International Journal of nanomedicine (rok: 2014, tom: 9, strony: 3913-3922), Wydawca: Dove Medical Press Ltd. New Zeland
    Status:
    Published
    DOI:
    10.2147/IJN.S65633 - link to the publication
  7. Carbon nanoparticles ndownregulate expression of basic fibroblast growth factor in the heart during embryogenesis
    Authors:
    Wierzbicki M., Sawosz E., Grodzik M., Hotowy A., Prasek M., Jaworski S., Sawosz F., Chwalibog A.
    Academic press:
    International Journal of Nanomedicine (rok: 2013, tom: 8, strony: 3427-3434), Wydawca: Dove medical Press Ltd. Albany, New Zeland
    Status:
    Published
    DOI:
    10.2147/IJN.S49745 - link to the publication
  8. Interaction of graphene family materials with Listeria monocytogenes and Salmonella enteritica
    Authors:
    Kurantowicz N., sawosz E., Jaworski S., Kutwin M., Strojny B., Wierzbicki M., Szeliga J., Hotowy A., Lipińska L., Koziński R., Jagiełło J., Chwalibog A.
    Academic press:
    Nanoscale Research Letters (rok: 2015, tom: 10, strony: 23-33), Wydawca: Springer Open Journal
    Status:
    Published
    DOI:
    10.1186/s11671-015-0749-y - link to the publication
  9. Międzynarodowe Zgłoszenie Patentowe PCT/EP2015/052429 Suspension of Graphene Oxide Nanoflakes in Water, Its Use and a Method of Preparation Thereof".
    Authors:
    Sawosz E., Kutwin M., Jaworski S., Wierzbicki M., Grodzik M., Hotowy A., Lipińska L., Jagiełło J. A. Chwalibog
    Academic press:
    PCT Request (rok: 2015, ), Wydawca: European Patent Office (EPO) (RO/EP)
    Status:
    Published
  10. Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma multiforme
    Authors:
    Maciej Szmidt, Adrian Stankiewicz, Kaja Urbańska, Sławomir Jaworski3, Marta Kutwin, Mateusz Wierzbicki, Marta Grodzik, Beata Burzyńska, Monika Góra, André Chwalibog, Ewa Sawosz
    Academic press:
    BMC Genomic (rok: 2017, ), Wydawca: Biomed Central The Open Access publisher
    Status:
    Submitted
    DOI:
    brak - link to the publication
  11. Comparison of tumor morphology and structure from U87 and U118 glioma cells cultured on chicken embryo chorioallantoic membrane
    Authors:
    Jaworski S., Sawosz E., Grodzik M., Kutwin M., Wierzbicki M., Włodyga K., Jasik A., Reichert M., Chwalibog A.
    Academic press:
    Bulletin of the Veterinary Institute in Pulawy (rok: 2013, tom: 57, strony: 593-598), Wydawca: Natl. Veterinary Research Inst. Puławy Poland
    Status:
    Published
    DOI:
    10.2478/bvip-2013-0101 - link to the publication
  12. Nano-nutrition of chicken embryos. The effect of in ovo administration of diamond nanoparticles and L-Glutamine on molecular responses in chicken embryo pectoral muscles
    Authors:
    Grodzik M., Sawosz F., Sawosz E., Hotowy A., Wierzbicki M., Kutwin M., Jaworski S., Chwalibog A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2013, tom: 14, strony: 23033-23044), Wydawca: MDPI AG, Postfach, CH-4005 Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms141123033 - link to the publication

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