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Information on the principal investigator and host institution

Information of the project and the call

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Exotic beta-sheet conformations in chiral superstructures of peptide fibrils

2011/03/B/ST4/03063

Keywords:

amyloid fibrils beta-sheet spectroscopic detection of structural defects in proteins protein misfolding superstructural chirality bifurcated hydrogen bonds vibrational circular dichroism

Descriptors:

  • ST4_4: Theoretical and computational chemistry
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

UNIWERSYTET WARSZAWSKI, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Wojciech Dzwolak 

Number of co-investigators in the project: 3

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 481 000 PLN

Project start date (Y-m-d): 2012-08-10

Project end date (Y-m-d): 2015-08-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  1. Chain-Length Bidispersity Triggers Explosive Self-Assembly of Poly-L-Glutamic Acid β2-Fibrils
    Authors:
    A. Hernik-Magoń, W. Puławski, B. Fedorczyk, D. Tymecka, A. Misicka, P. Szymczak, W. Dzwolak
    Academic press:
    Biomacromolecules (rok: 2016, tom: 17, strony: 1376–1382), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biomac.5b01770 - link to the publication
  2. Chirality and Chiroptical Properties of Amyloid Fibrils
    Authors:
    W. Dzwolak
    Academic press:
    Chirality (rok: 2014, tom: 26, strony: 220–227), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chir.22335 - link to the publication
  3. Covalent Defects Restrict Supramolecular Self-Assembly of Homopolypeptides: Case Study of β2-Fibrils of Poly-L-Glutamic Acid
    Authors:
    A. Fulara A, A. Hernik, H. Nieznańska, W. Dzwolak
    Academic press:
    PLoS ONE (rok: 2014, tom: 9, strony: e105660), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0105660 - link to the publication
  4. Amyloidogenic properties of short α-L-glutamic acid oligomers
    Authors:
    A. Hernik, W. Puławski, B. Fedorczyk, D. Tymecka, A. Misicka, S. Filipek, W. Dzwolak
    Academic press:
    Langmuir (rok: 2015, tom: 31, strony: 10500-10507), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.5b02915 - link to the publication

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