Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of mitochondrial DNA and epigenetic factors in the pathogenesis of Huntington's disease

2011/03/B/NZ2/01422

Keywords:

Huntington's disease mtDNA mitochondria CAG mutation

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_3: Proteomics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Limon 

Number of co-investigators in the project: 7

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 681 500 PLN

Project start date (Y-m-d): 2012-08-13

Project end date (Y-m-d): 2017-08-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputer (3 314 PLN)
  2. termocykler (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. Expression of RNAs Coding for Metal Transporters in Blood of Patients with Huntington's Disease
    Authors:
    Monika Szeliga, Aleksandra Różycka, Paulina Jędrak, Sylwia Barańska, Piotr Janik, Zygmunt Jamrozik, Jan Albrecht
    Academic press:
    Neurochemical Research (rok: 2016, tom: 41, strony: 101-106), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-015-1737-4 - link to the publication
  2. Mitochondrial DNA levels in Huntington disease leukocytes and dermal fibroblasts
    Authors:
    Paulina Jędrak, Magdalena Krygier, Katarzyna Tońska, Agnieszka Drozd, Magdalena Kaliszewska, Ewa Bartnik, Witold Sołtan, Emilia J. Sitek, Anna Stanisławska-Sachadyn, Janusz Limon, Jarosław Sławek, Grzegorz Węgrzyn, Sylwia Barańska
    Academic press:
    Metabolic Brain Disease (rok: 2017, tom: 32, strony: 1237-1247), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11011-017-0026-0 - link to the publication
  3. A simple modification to improve the accuracy of methylation-sensitive restriction enzyme quantitative polymerase chain reaction.
    Authors:
    Magdalena Krygier, Justyna Podolak-Popinigis, Janusz Limon, Paweł Sachadyn, Anna Stanisławska-Sachadyn
    Academic press:
    Analytical Biochemistry (rok: 2016, tom: 500, strony: 88-90), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2016.01.020 - link to the publication
  1. Can Dna Methylation Be A Factor In The Pathogenesis Of Huntington's Disease?
    Authors:
    Anna Stanisławska-Sachadyn, Magdalena Krygier, Sylwia Barańska, Paulina Jędrak, Witold Sołtan, Emilia J. Sitek, Krzysztof Banaszkiewicz, Piotr Janik, Monika Rudzińska, Grzegorz Węgrzyn, Daniel Zielonka, Jarosław Sławek, Janusz Limon
    Conference:
    European Huntington's Disease Network, 8th Plenary Meeting (rok: 2014, ), Wydawca: Journal of Neurology Neurosurgery & Psychiatry
    Data:
    konferencja 19-21.09.2014
    Status:
    Published
    DOI:
    link to the publication
  2. Differential mitochondrial DNA levels in HD patients depending on the cell type
    Authors:
    Sylwia Barańska, Paulina Jędrak, Magdalena Krygier, Katarzyna Tońska, Małgorzata Drozd, Ewa Bartnik, Witold Sołtan, Emilia J. Sitek, Anna Stanisławska-Sachadyn, Janusz Limon, Jarosław Sławek, Grzegorz Węgrzyn
    Conference:
    EHDN2016 Plenary Meeting (rok: 2016, ), Wydawca: Journal of Neurology Neurosurgery & Psychiatry
    Data:
    konferencja 16-18.09.2016
    Status:
    Published
    DOI:
    link to the publication
  3. The Significance The Level Of Mitochondrial Dna In Huntington's Disease
    Authors:
    Paulina Jędrak, Sylwia Barańska, Magdalena Krygier, Anna Stanisławska-Sachadyn, Witold Sołtan, Emilia J. Sitek, Jarosław Sławek, Janusz Limon, Grzegorz Węgrzyn
    Conference:
    European Huntington's Disease Network, 8th Plenary Meeting (rok: 2014, ), Wydawca: Journal of Neurology Neurosurgery & Psychiatry
    Data:
    konferencja 19-21.09.2014
    Status:
    Published
    DOI:
    link to the publication

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