Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Design, synthesis and biological evaluation of methylthio analogues of combretastatin A-4 - potential antimitotic agents

2011/03/B/NZ7/00509

Keywords:

cancer chemotherapy stilbenes thio-derivatives combretastatin A-4 microtubules apoptosis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ2_7: Bioinformatics
  • ST5_16:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Stanisław Sobiak 

Number of co-investigators in the project: 9

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 338 777 PLN

Project start date (Y-m-d): 2012-08-22

Project end date (Y-m-d): 2015-08-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw wyparny Hei-Vap Advantage z pompą próżniową SC920 (26 900 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Tubulin-interactive stilbene derivatives as anticancer agents
    Authors:
    Mikstacka Renata, Stefański Tomasz, Różański Jakub
    Academic press:
    Cellular & Molecular Biology Letters (rok: 2013, tom: 18, strony: 368-397), Wydawca: Versita and Springer-Verlag
    Status:
    Published
    DOI:
    10.2478/s11658-013-0094-z - link to the publication
  2. Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents
    Authors:
    Tomasz Stefański, Renata Mikstacka, Rafał Kurczab, Zbigniew Dutkiewicz, Małgorzata Kucińska, Marek Murias, Małgorzata Zielińska-Przyjemska, Michał Cichocki, Anna Teubert, Mariusz Kaczmarek, Adam Hogendorf, and Stanisław Sobiak
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2017, tom: in press, strony: in press), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ejmech.2017.11.050 - link to the publication

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