Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Neuroplasticity regulation by alternative gene transcription

2011/03/D/NZ3/01686

Keywords:

gene expression alternative promoters neuroplasticity psychotropic drugs next-generation sequencing

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_7: Bioinformatics

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Korostyński 

Number of co-investigators in the project: 4

Call: SONATA 2 - announced on 2011-09-15

Amount awarded: 834 000 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2018-08-05

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. serwer komputerowy ze stacją roboczą (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (7)
  • Book publications / chapters in book publications (1)
  1. Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.
    Authors:
    Ficek J, Zygmunt M, Piechota M, Hoinkis D, Rodriguez Parkitna J, Przewlocki R, Korostynski M.
    Academic press:
    BMC Genomics (rok: 2016, tom: 17, strony: 1), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s12864-016-2713-3 - link to the publication
  2. Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.
    Authors:
    Zygmunt M, Hoinkis D, Hajto J, Piechota M, Skupień-Rabian B, Jankowska U, Kędracka-Krok S, Rodriguez Parkitna J, Korostyński M
    Academic press:
    BMC Neuroscience (rok: 2018, tom: 19(1):55, strony: 45305), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12868-018-0458-4 - link to the publication
  3. ENDOGENOUS OPIOIDS REGULATE GLUCOCORTICOID-DEPENDENT STRESS-COPING STRATEGIES IN MICE
    Authors:
    KLAUDIA SZKLARCZYK, MICHAL KOROSTYNSKI, SLAWOMIR GOLDA, MARCIN PIECHOTA, JOANNA FICEK AND RYSZARD PRZEWLOCKI
    Academic press:
    Neuroscience (rok: 2016, tom: 330, strony: 121-137), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2016.05.034 - link to the publication
  4. Regulation of alternative gene transcription in the striatum in response to antidepressant drugs.
    Authors:
    Piechota M, Golda S, Ficek J, Jantas D, Przewlocki R, Korostynski M.
    Academic press:
    Neuropharmacology (rok: 2015, tom: 99, strony: 328-36), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2015.08.006 - link to the publication
  5. Seqinspector: position-based navigation through the ChIP-seq data landscape to identify gene expression regulators.
    Authors:
    Piechota M, Korostynski M, Ficek J, Tomski A, Przewlocki R
    Academic press:
    BMC Bioinformatics (rok: 2016, tom: 1, strony: 1), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s12859-016-0938-4 - link to the publication
  6. Transcriptional signatures of steroid hormones in the striatal neurons and astrocytes.
    Authors:
    Piechota M, Korostynski M, Golda S, Ficek J, Jantas D, Barbara Z, Przewlocki R
    Academic press:
    BMC Neuroscience (rok: 2017, tom: 18(1):37, strony: 45300), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12868-017-0352-5 - link to the publication
  7. Decoding the transcriptional programs activated by psychotropic drugs in the brain
    Authors:
    Zygmunt M, Piechota M, Rodriguez Parkitna J, Korostynski M
    Academic press:
    Genes, Brain and Behavior (rok: 2018, tom: 2018; e12511, strony: 45301), Wydawca: John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society
    Status:
    Published
    DOI:
    10.1111/gbb.12511 - link to the publication
  1. Molecular classification of psychotropic drugs and selection of transcriptional biomarkers of response to antidepressant
    Authors:
    Michal Korostynski, Piechota Marcin, Joanna Ficek, Ryszard Przewlocki
    Conference:
    Precision Medicine: Personal Genomes & Pharmacogenomics (rok: 2014, ), Wydawca: Cold Spring Harbor
    Data:
    konferencja listopad 12 - 15
    Status:
    Published
  2. Neuronal activity-regulated expression of alternative transcriptional variants
    Authors:
    Korostyński M., Piechota M., Gołda S., Przewłocki R.
    Conference:
    The Biology of Genomes 2013 (rok: 2013, ), Wydawca: Cold Spring Harbor Laboratory, New York, USA
    Data:
    konferencja 5,2013
    Status:
    Published
  3. Global analysis of drug-regulated alternative expression of genes in mouse brain
    Authors:
    Korostyński M., Piechota M., Gołda S., Przewłocki R.
    Conference:
    11th International Congress of the Polish Neuroscience Society (rok: 2013, ), Wydawca: Polskie Towarzystwo Badań Układu Nerwowego
    Data:
    konferencja 15-17.09.2013
    Status:
    Published
  4. Identification and classification of transcriptional variants and non-coding RNAs induced by antidepressants in the mouse striatum
    Authors:
    Marcin Piechota, Slawomir Golda, Danuta Jantas, Ryszard Przewlocki, Michal Korostynski
    Conference:
    XII Międzynarodowe Sympozjum Neurochemiczne (rok: 2014, ), Wydawca: brak
    Data:
    konferencja 20-21 listopada
    Status:
    Published
  5. Selective induction of alternate gene transcripts by cocaine treatment
    Authors:
    M. A. Zygmunt, J. Rodriguez Parkitna, S. Golda, M. Piechota, J. Ficek, M. Korostyński
    Conference:
    NEUROSCIENCE 2015 (rok: 2015, ), Wydawca: SFN
    Data:
    konferencja 17-21.11.2015
    Status:
    Published
  6. Regulation of alternative gene expression in the mouse striatum in response to cocaine
    Authors:
    Magdalena Zygmunt, Jan Rodriguez Parkitna, Sławomir Gołda, Marcin Piechota, Joanna Ficek, Michał Korostyński
    Conference:
    12th International Congress of the Polish Neuroscience Society (rok: 2015, ), Wydawca: PTBUN
    Data:
    konferencja 9,2015
    Status:
    Published
  7. Identification and classification of stimuliinduced transcriptional variants and noncoding RNAs in the mouse brain
    Authors:
    Marcin Piechota, Slawomir Golda, Danuta Jantas, Ryszard Przewlocki, Michal Korostynski
    Conference:
    9th FENS 2014 (rok: 2014, ), Wydawca: brak
    Data:
    konferencja June 5-9
    Status:
    Published
  1. High-Throughput Gene Expression Profiling of Opioid-Induced Alterations in Discrete Brain Areas
    Authors:
    Michal Korostynski, Marcin Piechota, Slawomir Golda, Ryszard Przewlocki
    Book:
    Opioid Receptors (rok: 2015, tom: Part I, strony: pp 65-76), Wydawca: Springer New York
    Status:
    Published

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