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Investigation of histidine phosphorylation in thymidylate synthase and searching for causative protein kinase

2011/03/B/NZ1/00135

Keywords

Descriptors

  • NZ1_2: Biochemia
  • NZ5_7: Leczenie chorób człowieka

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Politechnika Warszawska

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Joanna Cieśla

Number of co-investigators in the project: 4

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
346 000 PLN
Project start date
2012-08-02
Project end date
2016-04-01
Project duration
44 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy horyzontalnej z regulatorem temperatury. Cost: 30 000 PLN
  2. Aparat do elektroforezy pionowej.
  3. Mini wirówka.
  4. wirówka z chłodzeniem i wyposażeniem. Cost: 43 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells

    Authors:
    Antosiewicz A, Jarmuła A, Przybylska D, Mosieniak G, Kowalkowska A, Szczepanowska J, Rode W, Cieśla J
    Academic press:
    Journal of Biomolecular Structure and Dynamics (year: 2017, volume: 35, pages: 1474-1490), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/07391102.2016.1186560 – link to the publication

  2. Quartz crystal microbalance with dissipation and microscale thermophoresis as tools for investigation of protein complex formation between thymidylate synthesis cycle enzymes

    Authors:
    Antosiewicz A, Senkara E, Cieśla J.
    Academic press:
    BIOSENSORS & BIOELECTRONICS (year: 2015, volume: 64, pages: 36-42), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2014.08.031. – link to the publication

Articles in post-conference publications (4)

  1. Formation of the complex between human thymidylate synthase and dihydrofolate reductase, the enzymes involved in thymidylate biosynthesis

    Authors:
    Antosiewicz A, Senkara-Barwijuk E,Wilk P, Jarmuła A, Rode W, Cieśla J
    Conference:
    Federation of European Biochemical Societies CONGRESS 2013 Mechanisms in Biology (year: 2013, pages: 481), Publisher: Wiley-Blackwell
    Date:
    conference 6-11 lipca
    Status:
    Published
    DOI:
    link to the publication

  2. Investigation of thymidylate synthase phosphorylation and searching for causative protein kinase

    Authors:
    Wińska P., Skierka K., Cieśla J.
    Conference:
    8th International Conference. Inhibitors of protein kinases (year: 2014, pages: 35), Publisher: Institute of Biochemistry and Biophysics, PAS, Warsaw
    Date:
    conference 21-25 września
    Status:
    Published

  3. Investigation of human thymidylate synthase phosphorylation

    Authors:
    Skierka K, Wińska P, Cieśla J
    Conference:
    10th PhD Students and Young Scientists Conference: Young Scientists Towards the Challenges of Modern Technology (year: 2015, pages: CD Proceedings — ISBN 978-83-935118-3-9, s.1–2.), Publisher: Warsaw University of Technology
    Date:
    conference 21-23 September 2015
    Status:
    Published

  4. QCM-D study of the serine hydroxymethylotransferase - thymidylate synthase - dihydrofolate reductase tri-complex

    Authors:
    E. Senkara-Barwijuk, A. Antosiewicz, K. Gazda, J. Ciesla
    Conference:
    Federation of European Biochemical Societies CONGRESS 2013 Mechanisms in Biology (year: 2013, pages: 481), Publisher: Wiley-Blackwell
    Date:
    conference 06-11 lipca
    Status:
    Published
    DOI:
    link to the publication

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