Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Investigation of histidine phosphorylation in thymidylate synthase and searching for causative protein kinase

2011/03/B/NZ1/00135

Keywords:

protein histidine kinase phosphorylation protein purification

Descriptors:

  • NZ1_2: Biochemistry
  • NZ5_7: Human disease treatment

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

POLITECHNIKA WARSZAWSKA

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Cieśla 

Number of co-investigators in the project: 4

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 346 000 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2016-04-01

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mini wirówka.
  2. Aparat do elektroforezy horyzontalnej z regulatorem temperatury (30 000 PLN)
  3. Aparat do elektroforezy pionowej.
  4. wirówka z chłodzeniem i wyposażeniem (43 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells
    Authors:
    Antosiewicz A, Jarmuła A, Przybylska D, Mosieniak G, Kowalkowska A, Szczepanowska J, Rode W, Cieśla J
    Academic press:
    Journal of Biomolecular Structure and Dynamics (rok: 2017, tom: 35, strony: 1474-1490), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/07391102.2016.1186560 - link to the publication
  2. Quartz crystal microbalance with dissipation and microscale thermophoresis as tools for investigation of protein complex formation between thymidylate synthesis cycle enzymes
    Authors:
    Antosiewicz A, Senkara E, Cieśla J.
    Academic press:
    BIOSENSORS & BIOELECTRONICS (rok: 2015, tom: 64, strony: 36-42), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2014.08.031. - link to the publication
  1. Formation of the complex between human thymidylate synthase and dihydrofolate reductase, the enzymes involved in thymidylate biosynthesis
    Authors:
    Antosiewicz A, Senkara-Barwijuk E,Wilk P, Jarmuła A, Rode W, Cieśla J
    Conference:
    Federation of European Biochemical Societies CONGRESS 2013 Mechanisms in Biology" (rok: 2013, ), Wydawca: Wiley-Blackwell
    Data:
    konferencja 6-11 lipca
    Status:
    Published
    DOI:
    link to the publication
  2. Investigation of thymidylate synthase phosphorylation and searching for causative protein kinase
    Authors:
    Wińska P., Skierka K., Cieśla J.
    Conference:
    8th International Conference. Inhibitors of protein kinases (rok: 2014, ), Wydawca: Institute of Biochemistry and Biophysics, PAS, Warsaw
    Data:
    konferencja 21-25 września
    Status:
    Published
  3. Investigation of human thymidylate synthase phosphorylation
    Authors:
    Skierka K, Wińska P, Cieśla J
    Conference:
    10th PhD Students and Young Scientists Conference: Young Scientists Towards the Challenges of Modern Technology (rok: 2015, ), Wydawca: Warsaw University of Technology
    Data:
    konferencja 21-23 September 2015
    Status:
    Published
    DOI:
    link to the publication
  4. QCM-D study of the serine hydroxymethylotransferase - thymidylate synthase - dihydrofolate reductase tri-complex
    Authors:
    E. Senkara-Barwijuk, A. Antosiewicz, K. Gazda, J. Ciesla
    Conference:
    Federation of European Biochemical Societies CONGRESS 2013 "Mechanisms in Biology" (rok: 2013, ), Wydawca: Wiley-Blackwell
    Data:
    konferencja 06-11 lipca
    Status:
    Published
    DOI:
    link to the publication

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