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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of heat shock protein HSP72 in the development of lipid-induced insulin resistance in skeletal muscle

2011/03/B/NZ3/00693

Keywords:

heat shock proteins insulin resistance lipids skeletal muscle

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_2: Cell physiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Dobrzyń 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 704 000 PLN

Project start date (Y-m-d): 2012-08-21

Project end date (Y-m-d): 2016-08-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Detektor spektrometrii mas do chromatografu gazowego Agillent 7890A. (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (9)
  1. Adipose- and muscle-derived Wnts trigger pancreatic B-cell adaptation to systemic insulin resistance
    Authors:
    Kamil Kozinski, Magdalena Jazurek, Pawel Dobrzyn, Justyna Janikiewicz, Anna Gajda, Agnieszka Dobrzyn
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 31553), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep31553 - link to the publication
  2. Islet beta-cell failure in type 2 diabetes - Within the network of toxic lipids
    Authors:
    Justyna Janikiewicz, Katarzyna Hanzelka, Kamil Koziński, Katarzyna Kolczynska, Agnieszka Dobrzyń
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2015, tom: 460, strony: 491-496), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2015.03.153 - link to the publication
  3. Differential regulation of serum microRNA expression by HNF1B and HNF1a transcription factors
    Authors:
    Wojciech Fendler, Joanna Madzio, Kamil Kozinski, Kashyap Patel, Justyna Janikiewicz, Magdalena Szopa, Adam Tracz, Maciej Borowiec, Przemyslawa Jarosz-Chobot, Malgorzata Mysliwiec, Agnieszka Szadkowska, Andrew T. Hattersley, Sian Ellard, Maciej T. Malecki, Agnieszka Dobrzyn, Wojciech Mlynarski
    Academic press:
    Diabetologia (rok: 2016, tom: 59, strony: 1463-1473), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00125-016-3945-0 - link to the publication
  4. Rola białka szoku cieplnego Hsp72 w fizjologii i patologii mięśni szkieletowych
    Authors:
    Katarzyna Kolczynska, Agnieszka Dobrzyn
    Academic press:
    Postępy Biochemii (rok: 2016, tom: nieznany, strony: nieznane), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Submitted
    DOI:
    nieznane - link to the publication
  1. HSP72 improves insulin sensitivity via mitochondrial-related pathway
    Authors:
    Katarzyna Hanzelka, Katarzyna Kolczyńska, Katarzyna Mnich, Agnieszka Dobrzyń
    Conference:
    48th Annual Scientific Meeting of the European Society for Clinical Investigation (rok: 2014, ), Wydawca: European Society for Clinical Investigation
    Data:
    konferencja 30 kwiecień - 3 maj
    Status:
    Published
    DOI:
    link to the publication
  2. Heat Shock Protein 72 improves insulin sensitivity by decreasing lipid accumulation in skeletal muscle
    Authors:
    Katarzyna Kolczynska, Katarzyna Hanzelka, Agnieszka Dobrzyn
    Conference:
    The 2016 Obesity Summit (rok: 2016, ), Wydawca: European Association for the Study of Obesity
    Data:
    konferencja 12 -14 kwiecień
    Status:
    Published
  3. Regulation of insulin sensitivity by endogenously synthesized 2-AG in skeletal muscle is associated with SCD1 gene expression
    Authors:
    Aleksandra Rumińska, Agnieszka Dobrzyń
    Conference:
    44th European Muscle Conference, Warszawa (rok: 2015, ), Wydawca: European Muscle Conference
    Data:
    konferencja 21 - 25 wrzesień
    Status:
    Published
  4. Heat Shock Protein 72 protects against lipid-induced insulin resistance in skeletal muscle via AMPK and CaMKK upregulation
    Authors:
    Katarzyna Kolczyńska, Katarzyna Hanzelka, Anna Gajda, Agnieszka Dobrzyń
    Conference:
    44th European Muscle Conference, Warszawa (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 21 - 25 wrzesień
    Status:
    Published
  5. Upregulated tRNA level alters insulin signaling in C2C12 myotubes
    Authors:
    Anna Gajda, Aleksandra Rumińska, Agnieszka Dobrzyń
    Conference:
    25th tRNA Conference (rok: 2014, ), Wydawca: University of Patras, Grecja
    Data:
    konferencja 21 - 25 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  6. Heat shock protein 72 protects against lipid induced insulin resistance via upregulation of AMPK in skeletal muscle
    Authors:
    Katarzyna Kolczyńska, Katarzyna Hanzelka, Anna Gajda, Agnieszka Dobrzyń
    Conference:
    FEBS EMBO 2014 Conference (rok: 2014, ), Wydawca: Federation of European Biochemical Societes
    Data:
    konferencja 30 sierpień - 4 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  7. Overexpression of HSP72 decreases lipid accumulation, improves insulin sensitivity and upregulates AMPK pathway in C2C12 cells
    Authors:
    Katarzyna Kolczyńska, Katarzyna Hanzelka, Anna Gajda, Agnieszka Dobrzyń
    Conference:
    Cellular imaging of lipids (rok: 2014, ), Wydawca: European Molecular Biology Organization
    Data:
    konferencja 2 - 6 czerwiec
    Status:
    Published
    DOI:
    link to the publication
  8. Role of heat shock protein 72 in regulation of insulin sensitivity in skeletal muscle
    Authors:
    Katarzyna Kolczyńska, Anna Gajda, Katarzyna Hanzelka, Agnieszka Dobrzyń
    Conference:
    1st Nencki Institute Phd Student Conference, Warszawa (rok: 2013, ), Wydawca: Instytut Biologii Doświadczalnej PAN
    Data:
    konferencja 16-18 październik
    Status:
    Published
  9. HSP72 improves insulin sensitivity and diminishes lipid accumulation in skeletal muscle
    Authors:
    Katarzyna Hanzelka
    Conference:
    14EME Journee Scientifique (rok: 2014, ), Wydawca: Institut Multidisciolinaire de Biochemie des Lipides
    Data:
    konferencja 11 czerwiec
    Status:
    Published
    DOI:
    link to the publication

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