Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The optimal rate of cooling and protection against brain hyperferremia - as a potential therapy of neonatal asphyxia

2011/03/B/NZ7/00682

Keywords:

asphyxia temperature hyperthermia hypothermia anapyrexia oxidative stress antioxidant enzymes iron deferoxamine HIF-1α. (hypoxia inducible factor 1)

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Mikołaja Kopernika, Wydział Biologii i Ochrony Środowiska

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Justyna Rogalska 

Number of co-investigators in the project: 4

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 244 440 PLN

Project start date (Y-m-d): 2012-08-22

Project end date (Y-m-d): 2016-08-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zamrażarka laboratoryjna -80 (27 000 PLN)
  2. tablet.
  3. Iso thermex - aparatura do pomiaru temperatury ciała zwierząt (35 300 PLN)
  4. komputer (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (5)
  1. Deferoxamine prevents cerebral glutathione and vitamin E depletions in asphyxiated neonatal rats: role of body temperature
    Authors:
    Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Woźniak, Michał Caputa & Justyna Rogalska
    Academic press:
    International Journal of Hyperthermia (rok: 2016, tom: 32, strony: 211-220), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/02656736.2015.1125955 - link to the publication
  2. Deferoxamine improves antioxidative protection in the brain of neonatal rats: The role of anoxia and body temperature.
    Authors:
    Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Woźniak, Michał Caputa, Justyna Rogalska
    Academic press:
    Neuroscience Letters (rok: 2016, tom: 628, strony: 116-122), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2016.06.022 - link to the publication
  3. Effects of body temperature on post-anoxic oxidative stress from the perspective of postnatal physiological adaptive processes in rats
    Authors:
    H. Kletkiewicz, J. Rogalska, A. Nowakowska, A. Wozniak, C. Mila-Kierzenkowska, M. Caputa
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2016, tom: 67, strony: 287-299), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Activation of hypoxia-inducible factor-1 in rat brain after perinatal anoxia: role of body temperature
    Authors:
    Hanna Kletkiewicz, Malwina Hyjek, Krzysztof Jaworski, Anna Nowakowska, Justyna Rogalska
    Academic press:
    International Journal of Hyperthermia (rok: 2017, ), Wydawca: Taylor&Francis
    Status:
    Accepted for publication
    DOI:
    10.1080/02656736.2017.1385860 - link to the publication
  1. The neuroprotective effects of deferoxamine in newborn rats exposed to anoxia
    Authors:
    H. Kletkiewicz , J. Rogalska, A. Nowakowska, A. Woźniak, C. Mila-Kierzenkowska
    Conference:
    48th Congress of the Polish Biochemical Society, Toruń (rok: 2013, ), Wydawca: Acta Biochimica Polonica, vol. 60, supplement 1/2013; Polish Biochemical Society&Polish Academy of Sciences
    Data:
    konferencja 2-5.09.2013
    Status:
    Published
  2. Deferoxamine improves antioxidative protection of the brain in neonatal rats - role of anoxia and body temperature
    Authors:
    Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Wozniak, Michał Caputa, Justyna Rogalska
    Conference:
    10th FENS Forum of Neuroscience 2016 (rok: 2016, ), Wydawca: Federation of European Neuroscience Societies
    Data:
    konferencja 2-6.07.2016
    Status:
    Published
  3. Effect of body temperature on oxidative stress in newborn rats exposed to anoxia
    Authors:
    H. Kletkiewicz , J. Rogalska, A. Nowakowska, A. Woźniak, C. Mila-Kierzenkowska
    Conference:
    1.The XXII International Symposium of MOLECULAR AND PHYSSIOLOGICAL ASPECTS OF REGULATORY PROCESSES OF THE ORGANISM (rok: 2013, ), Wydawca: Józef Dietl Malopolska Higher School of Cracow, druk: Wydawnictwo Abaton
    Data:
    konferencja 14-15.06. 2013
    Status:
    Published
  4. Anapyrexia sets the safe coolimg limit for asphyxiated newborns
    Authors:
    H. Kletkiewicz, A. Nowakowska, A. Woźniak, C. Mila-Kierzenkowska, J. Rogalska
    Conference:
    The 5th International Meeting on the Physiology and Pharmacology of Temperature Regulation, Skukuza, South Africa (rok: 2014, ), Wydawca: University of the Witwatersrand, Johannesburg
    Data:
    konferencja 7-11.09.2014
    Status:
    Published
  5. Effects of body temperature and hyperferremia on glutathione and vitamin E levels in the brain of asphyxiated neonatal rat
    Authors:
    Justyna Rogalska, Hanna Kletkiewicz, Anna Nowakowska, Alina Woźniak, Celestyna Mila-Kierzenkowska
    Conference:
    12th International Congress of the Polish Neuroscience Society (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 6-8.09.2015
    Status:
    Published

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