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The optimal rate of cooling and protection against brain hyperferremia - as a potential therapy of neonatal asphyxia

2011/03/B/NZ7/00682

Keywords

Descriptors

  • NZ7_12: Prewencja chorób człowieka
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Mikołaja Kopernika, Wydział Biologii i Ochrony Środowiska

Voivodeship: kujawsko-pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Justyna Żaneta Rogalska

Number of co-investigators in the project: 4

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
244 440 PLN
Project start date
2012-08-22
Project end date
2016-08-21
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Iso thermex - aparatura do pomiaru temperatury ciała zwierząt. Cost: 35 300 PLN
  2. Zamrażarka laboratoryjna -80. Cost: 27 000 PLN
  3. komputer. Cost: 3 000 PLN
  4. tablet.

Information in the final report

Publication in academic press/journals (4)

  1. Deferoxamine improves antioxidative protection in the brain of neonatal rats: The role of anoxia and body temperature.

    Authors:
    Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Woźniak, Michał Caputa, Justyna Rogalska
    Academic press:
    Neuroscience Letters (year: 2016, volume: 628, pages: 116-122), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2016.06.022 – link to the publication

  2. Effects of body temperature on post-anoxic oxidative stress from the perspective of postnatal physiological adaptive processes in rats

    Authors:
    H. Kletkiewicz, J. Rogalska, A. Nowakowska, A. Wozniak, C. Mila-Kierzenkowska, M. Caputa
    Academic press:
    Journal of Physiology and Pharmacology (year: 2016, volume: 67, pages: 287-299), Publisher: Polish Physiological Society
    Status:
    Published

  3. Deferoxamine prevents cerebral glutathione and vitamin E depletions in asphyxiated neonatal rats: role of body temperature

    Authors:
    Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Woźniak, Michał Caputa & Justyna Rogalska
    Academic press:
    International Journal of Hyperthermia (year: 2016, volume: 32, pages: 211-220), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/02656736.2015.1125955 – link to the publication

  4. Activation of hypoxia-inducible factor-1 in rat brain after perinatal anoxia: role of body temperature

    Authors:
    Hanna Kletkiewicz, Malwina Hyjek, Krzysztof Jaworski, Anna Nowakowska, Justyna Rogalska
    Status:
    Accepted for publication

Articles in post-conference publications (5)

  1. Effect of body temperature on oxidative stress in newborn rats exposed to anoxia

    Authors:
    H. Kletkiewicz , J. Rogalska, A. Nowakowska, A. Woźniak, C. Mila-Kierzenkowska
    Conference:
    1.The XXII International Symposium of MOLECULAR AND PHYSSIOLOGICAL ASPECTS OF REGULATORY PROCESSES OF THE ORGANISM (year: 2013, pages: 122), Publisher: Józef Dietl Malopolska Higher School of Cracow, druk: Wydawnictwo Abaton
    Date:
    conference 14-15.06. 2013
    Status:
    Published

  2. The neuroprotective effects of deferoxamine in newborn rats exposed to anoxia

    Authors:
    H. Kletkiewicz , J. Rogalska, A. Nowakowska, A. Woźniak, C. Mila-Kierzenkowska
    Conference:
    48th Congress of the Polish Biochemical Society, Toruń (year: 2013, pages: 20), Publisher: Acta Biochimica Polonica, vol. 60, supplement 1/2013; Polish Biochemical Society&Polish Academy of Sciences
    Date:
    conference 2-5.09.2013
    Status:
    Published

  3. Deferoxamine improves antioxidative protection of the brain in neonatal rats - role of anoxia and body temperature

    Authors:
    Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Wozniak, Michał Caputa, Justyna Rogalska
    Conference:
    10th FENS Forum of Neuroscience 2016 (year: 2016, pages: sesja C.9.C, nr posteru C082), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 2-6.07.2016
    Status:
    Published

  4. Effects of body temperature and hyperferremia on glutathione and vitamin E levels in the brain of asphyxiated neonatal rat

    Authors:
    Justyna Rogalska, Hanna Kletkiewicz, Anna Nowakowska, Alina Woźniak, Celestyna Mila-Kierzenkowska
    Conference:
    12th International Congress of the Polish Neuroscience Society (year: 2015, pages: S50-S51), Publisher: Nencki Institute of Experimental Biology
    Date:
    conference 6-8.09.2015
    Status:
    Published

  5. Anapyrexia sets the safe coolimg limit for asphyxiated newborns

    Authors:
    H. Kletkiewicz, A. Nowakowska, A. Woźniak, C. Mila-Kierzenkowska, J. Rogalska
    Conference:
    The 5th International Meeting on the Physiology and Pharmacology of Temperature Regulation, Skukuza, South Africa (year: 2014, pages: 145), Publisher: University of the Witwatersrand, Johannesburg
    Date:
    conference 7-11.09.2014
    Status:
    Published

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